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Drd2
Gene Detail
Symbol

Name
ID
Drd2
dopamine receptor D2
MGI:94924
Synonyms
D2R, D2 receptor, Drd-2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
26.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr9:49340662-49407214 bp, + strand
From Ensembl annotation of GRCm38

  66553 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DRD2
Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd2

Human
homologs
DRD2, dopamine receptor D2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1813
neXtProt AC: NX_P14416

Human Synonyms: D2DR, D2R

Human Chr (Location): 11q23; chr11:113409595-113475279 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DRD2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show Parkinson's disease like symptoms, including akinetic and bradykinetic behavior. Mice lacking only the long isoform are hypoactive and exhibit increased sterotypic behavior in response to dopamine agonists.
 
Interactions
Drd2 interacts with 36 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (192 annotations)
Process acid secretion, activation of protein kinase activity, ...
Component acrosomal vesicle, axon, ...
Function dopamine binding, dopamine neurotransmitter receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (286)    Tissues (168)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 133
Western blot 8
RT-PCR 145
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase drd2 ; ZFIN drd2a, drd2b    NEW 
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(16) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032259 (Evidence)
Entrez Gene 13489 (Evidence)
UniGene 41970
DFCI TC1588287
DoTS DT.55283487
NIA Mouse Gene Index U010452
Consensus CDS Project CCDS40615.1
International Mouse Phenotyping Consortium Status Drd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032259 Ensembl Gene Model | MGI Sequence Detail 66553 C57BL/6J ±  kb
transcript ENSMUST00000075764 Ensembl | MGI Sequence Detail 1549 Not Applicable 
polypeptide ENSMUSP00000075170 Ensembl | MGI Sequence Detail 444 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(618 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001922 Dopamine D2 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001177 D(2) dopamine receptor
References
(Earliest) J:10932 Ratty AK, et al., Circling behavior exhibited by a transgenic insertional mutant. Brain Res Mol Brain Res. 1990 Oct;8(4):355-8
(Latest) J:221501 Ramirez MC, et al., Pituitary and brain dopamine D2 receptors regulate liver gene sexual dimorphism. Endocrinology. 2015 Mar;156(3):1040-51
All references(273)
Other
accession IDs
MGD-MRK-8893, MGD-MRK-8897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory