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Drd2
Gene Detail
 Symbol
Name
ID
Drd2
dopamine receptor D2
MGI:94924
Synonyms D2R, D2 receptor, Drd-2
Feature Type protein coding gene
Genetic Map
Chromosome 9
26.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr9:49340662-49407214 bp, + strand
From NCBI annotation of GRCm38

  66553 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd2

Human
homologs
Human Homolog DRD2, dopamine receptor D2
NCBI Gene ID 1813
neXtProt AC  NX_P14416
Human Synonyms  D2DR, D2R
Human Chr (Location)  11q23; chr11:113409595-113475685 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DRD2
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show Parkinson's disease like symptoms, including akinetic and bradykinetic behavior. Mice lacking only the long isoform are hypoactive and exhibit increased sterotypic behavior in response to dopamine agonists.
 
Interactions
Drd2 interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (176 annotations)
Process acid secretion, activation of protein kinase activity, ...
Component acrosomal vesicle, axon, ...
Function dopamine binding, dopamine neurotransmitter receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (278)    Tissues (168)    Images (35)
Theiler Stages: 10, 18, 19, 20, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 133
RT-PCR 145
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(16) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032259 (Evidence)
Entrez Gene13489 (Evidence)
UniGene41970
DFCITC1588287
DoTSDT.55283487
NIA Mouse Gene IndexU010452
Consensus CDS ProjectCCDS40615.1
International Mouse Knockout Project StatusDrd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13489 NCBI Gene Model | MGI Sequence Detail 66553 C57BL/6J ±  kb
transcript NM_010077 RefSeq | MGI Sequence Detail 1549 Not Specified 
polypeptide P61168 UniProt | EBI | MGI Sequence Detail 444 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms RFLP(3) : SNPs within 2kb(618 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001922 Dopamine D2 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001177 D(2) dopamine receptor
Graphical View of Protein Domain Structure
References (Earliest) J:10932 Ratty AK, et al., Circling behavior exhibited by a transgenic insertional mutant. Brain Res Mol Brain Res. 1990 Oct;8(4):355-8
(Latest) J:210602 Lewitus GM, et al., An adaptive role of TNFalpha in the regulation of striatal synapses. J Neurosci. 2014 Apr 30;34(18):6146-55
All references(265)
Other
accession IDs
MGD-MRK-8893, MGD-MRK-8897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory