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Drd2 Gene Detail
Summary
  • Symbol
    Drd2
  • Name
    dopamine receptor D2
  • Synonyms
    D2R, D2 receptor, Drd-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:94924
    NCBI Gene: 13489
  • Gene Overview
    MyGene.info: DRD2
Location & Maps
more
  • Sequence Map
    Chr9:49340627-49408177 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67551 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.72 cM
  • Mapping Data
    23 experiments
Homology
more
  • Human Ortholog
    DRD2, dopamine receptor D2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DRD2, dopamine receptor D2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D2DR, D2R
  • Links
    NCBI Gene ID: 1813
    neXtProt AC: NX_P14416
    UniProt: P14416

  • Chr Location
    11q23.2; chr11:113409595-113475279 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Drd2 mouse models; 1 with human DRD2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    149 phenotypes from 12 alleles in 24 genetic backgrounds
    42 phenotypes from multigenic genotypes
    157 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show Parkinson's disease like symptoms, including akinetic and bradykinetic behavior. Mice lacking only the long isoform are hypoactive and exhibit increased sterotypic behavior in response to dopamine agonists.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032259 Ensembl Gene Model | MGI Sequence Detail 67551 C57BL/6J ±  kb
transcript ENSMUST00000075764 Ensembl | MGI Sequence Detail 2547 Not Applicable  
polypeptide ENSMUSP00000075170 Ensembl | MGI Sequence Detail 444 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    620 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 4
    cDNA 16
    Primer pair 5
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-8893, MGD-MRK-8897
References
more
  • Summaries
    All 289
    Developmental Gene Expression 34
    Diseases 3
    Gene Ontology 88
    Phenotypes 157
  • Earliest
    J:10932 Ratty AK, et al., Circling behavior exhibited by a transgenic insertional mutant. Brain Res Mol Brain Res. 1990 Oct;8(4):355-8
  • Latest
    J:241384 Chen R, et al., The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory. J Biol Chem. 2017 Mar 17;292(11):4533-4543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory