Drd2
Gene Detail

Symbol Name ID

Drd2 dopamine receptor D2 MGI:94924

Synonyms

D2R, D2 receptor, Drd-2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

26.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr9:49340662-49407214 bp, + strand From NCBI annotation of GRCm38   66553 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd2

Human homologs

Human Homolog		DRD2, dopamine receptor D2
NCBI Gene ID		1813
neXtProt AC		NX_P14416
Human Synonyms		D2DR, D2R
Human Chr (Location)		11q23; chr11:113280317-113346001 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DRD2

Alleles and phenotypes

All alleles(13) : Targeted(12) Gene trapped(1)
 

Homozygous null mice show Parkinson's disease like symptoms, including akinetic and bradykinetic behavior. Mice lacking only the long isoform are hypoactive and exhibit increased sterotypic behavior in response to dopamine agonists.

 

Gene Ontology (GO) classifications

All GO classifications: (176 annotations)

Process	acid secretion, activation of protein kinase activity, ...
Component	acrosomal vesicle, axon, ...
Function	dopamine binding, dopamine neurotransmitter receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (278)    Tissues (168)    Images (35)
Theiler Stages: 10, 18, 19, 20, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	133
RT-PCR	145

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(4) cDNA(16) Primer pair(5) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032259 (Evidence)
Entrez Gene	13489 (Evidence)
UniGene	41970
DFCI	TC1588287
DoTS	DT.55283487
NIA Mouse Gene Index	U010452
Consensus CDS Project	CCDS40615.1
International Mouse Knockout Project Status	Drd2

Sequences

Length	Strain/Species
genomic	13489	NCBI Gene Model | MGI Sequence Detail	66553	C57BL/6J
transcript	NM_010077	RefSeq | MGI Sequence Detail	1549	Not Specified
polypeptide	P61168	UniProt | EBI | MGI Sequence Detail	444	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(3) : SNPs(491 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001922	Dopamine D2 receptor
InterPro	IPR000929	Dopamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001177	D(2) dopamine receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:10932 Ratty AK, et al., Circling behavior exhibited by a transgenic insertional mutant. Brain Res Mol Brain Res. 1990 Oct;8(4):355-8
(Latest) J:194227 Noain D, et al., Central dopamine d2 receptors regulate growth-hormone-dependent body growth and pheromone signaling to conspecific males. J Neurosci. 2013 Mar 27;33(13):5834-42
All references(252)

Other accession IDs

MGD-MRK-8893, MGD-MRK-8897