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Dlx3
Gene Detail
Symbol

Name
ID
Dlx3
distal-less homeobox 3
MGI:94903
Synonyms
Dlx-3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:95120119-95125296 bp, + strand
From VEGA annotation of GRCm38

  5178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DLX3
Gene Tree: Dlx3

Human
homologs
DLX3, distal-less homeobox 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1747
neXtProt AC: NX_O60479

Human Synonyms: AI4, TDO

Human Chr (Location): 17q21; chr17:49977079-49995224 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DLX3

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Genomic Mutations involving Dlx3 (2)
Incidental mutations (data from APF )
 
Homozygous null mutants die at embryonic day 9.5-10.0 with defects in the labyrinthine trophoblast of the chorioallantoic placenta.
 
Interactions
Dlx3 interacts with 205 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blood vessel development, multicellular organismal development, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (430)    Tissues (279)    Images (103)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 418
Northern blot 12
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DLX3 ; Xenbase dlx3 ; ZFIN dlx3b    NEW 
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001614 (Evidence)
Ensembl Gene Model ENSMUSG00000001510 (Evidence)
Entrez Gene 13393 (Evidence)
UniGene 5194
DFCI TC1584798
DoTS DT.55182523
NIA Mouse Gene Index U043216
Consensus CDS Project CCDS25272.1
International Mouse Phenotyping Consortium Status Dlx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001614 VEGA Gene Model | MGI Sequence Detail 5178 C57BL/6J ±  kb
transcript OTTMUST00000003155 VEGA | MGI Sequence Detail 2607 Not Applicable 
polypeptide OTTMUSP00000001527 VEGA | MGI Sequence Detail 287 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022135 Distal-less-like homeobox protein, N-terminal domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006529 homeobox protein DLX-3
References
(Earliest) J:5719 Eicher EM, et al., Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651-60
(Latest) J:221133 Tavares AL, et al., Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders. Dev Biol. 2015 Apr 15;400(2):191-201
All references(109)
Other
accession IDs
MGD-MRK-8859, MGD-MRK-8863, MGI:2144466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory