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Dlx3 Gene Detail
Summary
  • Symbol
    Dlx3
  • Name
    distal-less homeobox 3
  • Synonyms
    Dlx-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:94903
    NCBI Gene: 13393
  • Gene Overview
    MyGene.info: DLX3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95120119-95125296 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94903
protein coding gene Chr11:95120117-95125296 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018977
protein coding gene Chr11:97306619-97311796 (+)
A/J MGP_AJ_G0018945
protein coding gene Chr11:93379546-93384720 (+)
AKR/J MGP_AKRJ_G0018915
protein coding gene Chr11:96269012-96274186 (+)
BALB/cJ MGP_BALBcJ_G0018918
protein coding gene Chr11:93851411-93856582 (+)
C3H/HeJ MGP_C3HHeJ_G0018732
protein coding gene Chr11:96393653-96398826 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019370
protein coding gene Chr11:100370527-100375702 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017001
protein coding gene Chr11:90865693-90870858 (+)
CAST/EiJ MGP_CASTEiJ_G0018286
protein coding gene Chr11:97192572-97200819 (+)
CBA/J MGP_CBAJ_G0018703
protein coding gene Chr11:104472718-104477892 (+)
DBA/2J MGP_DBA2J_G0018811
protein coding gene Chr11:92954538-92959713 (+)
FVB/NJ MGP_FVBNJ_G0018800
protein coding gene Chr11:92417730-92422907 (+)
LP/J MGP_LPJ_G0018881
protein coding gene Chr11:97874851-97880028 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018827
protein coding gene Chr11:104521563-104526716 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019410
protein coding gene Chr11:96530998-96536179 (+)
PWK/PhJ MGP_PWKPhJ_G0018057
protein coding gene Chr11:93871352-93879827 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017846
protein coding gene Chr11:96215474-96220654 (+)
WSB/EiJ MGP_WSBEiJ_G0018335
protein coding gene Chr11:96452319-96457489 (+)



Homology
more
  • Human Ortholog
    DLX3, distal-less homeobox 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLX3, distal-less homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AI4, TDO
  • Links
    NCBI Gene ID: 1747
    neXtProt AC: NX_O60479
    UniProt: O60479

  • Chr Location
    17q21.33; chr17:49990005-49995224 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74544
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DLX3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DLX3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die at embryonic day 9.5-10.0 with defects in the labyrinthine trophoblast of the chorioallantoic placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001510 Ensembl Gene Model | MGI Sequence Detail 5178 C57BL/6J ±  kb
    transcript ENSMUST00000092768 Ensembl | MGI Sequence Detail 2607 Not Applicable  
    polypeptide ENSMUSP00000090443 Ensembl | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 3
      cDNA 21
      Primer pair 1
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8859, MGD-MRK-8863, MGI:2144466
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 89
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:5719 Eicher EM, et al., Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651-60
    • Latest
      J:277277 Zieman AG, et al., Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma. Hum Mol Genet. 2019 Jul 1;28(13):2255-2270

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory