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Dlx3
Gene Detail
 Symbol
Name
ID
Dlx3
distal-less homeobox 3
MGI:94903
Synonyms Dlx-3
Feature Type protein coding gene
Genetic Map
Chromosome 11
59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:95120119-95125296 bp, + strand
From VEGA annotation of GRCm38

  5178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dlx3

Human
homologs
Human Homolog DLX3, distal-less homeobox 3
NCBI Gene ID 1747
neXtProt AC  NX_O60479
Human Synonyms  AI4, TDO
Human Chr (Location)  17q21; chr17:49990005-49995224 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DLX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Genomic Mutations involving Dlx3 (1)
Incidental mutations (data from APF )
 
Homozygous null mutants die at embryonic day 9.5-10.0 with defects in the labyrinthine trophoblast of the chorioallantoic placenta.
 
Interactions
Dlx3 interacts with 206 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blood vessel development, multicellular organismal development, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (430)    Tissues (279)    Images (103)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 418
Northern blot 12
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001614 (Evidence)
Ensembl Gene ModelENSMUSG00000001510 (Evidence)
Entrez Gene13393 (Evidence)
UniGene5194
DFCITC1584798
DoTSDT.55182523
NIA Mouse Gene IndexU043216
Consensus CDS ProjectCCDS25272.1
International Mouse Knockout Project StatusDlx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001614 VEGA Gene Model | MGI Sequence Detail 5178 C57BL/6J ±  kb
transcript OTTMUST00000003155 VEGA | MGI Sequence Detail 2607 Not Applicable 
polypeptide OTTMUSP00000001527 VEGA | MGI Sequence Detail 287 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022135 Distal-less-like homeobox protein, N-terminal domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006529 homeobox protein DLX-3
References (Earliest) J:5719 Eicher EM, et al., Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651-60
(Latest) J:207523 Edlund RK, et al., Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1;390(1):1-13
All references(107)
Other
accession IDs
MGD-MRK-8859, MGD-MRK-8863, MGI:2144466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory