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Dlx3 Gene Detail
Summary
  • Symbol
    Dlx3
  • Name
    distal-less homeobox 3
  • Synonyms
    Dlx-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:94903
    NCBI Gene: 13393
  • Gene Overview
    MyGene.info: DLX3
Location & Maps
more
  • Sequence Map
    Chr11:95120119-95125296 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5178 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLX3, distal-less homeobox 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLX3, distal-less homeobox 3
    Orthology source: HomoloGene
  • Synonyms
    AI4, TDO
  • Links
    NCBI Gene ID: 1747
    neXtProt AC: NX_O60479

  • Chr Location
    17q21; chr17:49977079-49995224 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 74544
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DLX3
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human DLX3 associations

Human Disease Mouse Models
       Amelogenesis Imperfecta, Type IV; AI4   OMIM: 104510
Trichodentoosseous Syndrome; TDO   OMIM: 190320
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Dlx3
  • Incidental Mutations
    APF
Homozygous null mutants die at embryonic day 9.5-10.0 with defects in the labyrinthine trophoblast of the chorioallantoic placenta.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001614 VEGA Gene Model | MGI Sequence Detail 5178 C57BL/6J ±  kb
transcript OTTMUST00000003155 VEGA | MGI Sequence Detail 2607 Not Applicable  
polypeptide OTTMUSP00000001527 VEGA | MGI Sequence Detail 287 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    Genomic 3
    cDNA 20
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-8859, MGD-MRK-8863, MGI:2144466
References
more
  • Summaries
    All 113
    Developmental Gene Expression 72
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:5719 Eicher EM, et al., Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651-60
  • Latest
    J:229538 Zhao N, et al., DLX3 negatively regulates osteoclastic differentiation through microRNA-124. Exp Cell Res. 2016 Feb 15;341(2):166-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory