Dlx3
Gene Detail

Symbol Name ID

Dlx3 distal-less homeobox 3 MGI:94903

Synonyms

Dlx-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:95120089-95125296 bp, + strand From VEGA annotation of GRCm38   5208 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dlx3

Human homologs

Human Homolog		DLX3, distal-less homeobox 3
NCBI Gene ID		1747
neXtProt AC		NX_O60479
Human Synonyms		AI4, TDO
Human Chr (Location)		17q21; chr17:48067369-48072588 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DLX3

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous null mutants die at embryonic day 9.5-10.0 with defects in the labyrinthine trophoblast of the chorioallantoic placenta.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	blood vessel development, multicellular organismal development, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (61 records)
Data Summary: Results (368)    Tissues (225)    Images (91)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	356
Northern blot	12

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(3) cDNA(18) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001614 (Evidence)
Ensembl Gene Model	ENSMUSG00000001510 (Evidence)
Entrez Gene	13393 (Evidence)
UniGene	5194
DFCI	TC1584798
DoTS	DT.55182523
NIA Mouse Gene Index	U043216
Consensus CDS Project	CCDS25272.1
International Mouse Knockout Project Status	Dlx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001614	VEGA Gene Model | MGI Sequence Detail	5208	C57BL/6J
transcript	OTTMUST00000003155	VEGA | MGI Sequence Detail	2637	Not Applicable
polypeptide	OTTMUSP00000001527	VEGA | MGI Sequence Detail	287	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022135	Distal-less-like homeobox protein, N-terminal domain
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000006529	homeobox protein DLX-3

References

(Earliest) J:5719 Eicher EM, et al., Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651-60
(Latest) J:192641 Okano J, et al., Cutaneous retinoic acid levels determine hair follicle development and downgrowth. J Biol Chem. 2012 Nov 16;287(47):39304-15
All references(102)

Other accession IDs

MGD-MRK-8859, MGD-MRK-8863, MGI:2144466