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Dhh
Gene Detail
Symbol

Name
ID
Dhh
desert hedgehog
MGI:94891
Feature Type
protein coding gene
Genetic Map
Chromosome 15
55.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:98893031-98898540 bp, - strand
From Ensembl annotation of GRCm38

  5510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22431  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: DHH
Protein SuperFamily: hedgehog protein
Gene Tree: Dhh

Human
homologs
DHH, desert hedgehog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 50846
neXtProt AC: NX_O43323

Human Synonyms: GDXYM, HHG-3, SRXY7

Human Chr (Location): 12q13.1; chr12:49089421-49094819 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DHH

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Dhh (1)
Incidental mutations (data from APF )
 
Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds.
 
Human Diseases Modeled in Mice Using Dhh (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Dhh interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell-cell signaling, cell communication, ...
Component extracellular region, membrane, ...
Function calcium ion binding, hydrolase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (292)    Tissues (141)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
Northern blot 1
RT-PCR 184
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dhh ; ZFIN dhh    NEW 
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(13) Primer pair(6) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000023000 (Evidence)
Entrez Gene 13363 (Evidence)
DFCI TC1583773, TC1596210, TC1625014
DoTS DT.101149458, DT.524934, DT.94168087, DT.99851652
NIA Mouse Gene Index U036637
Consensus CDS Project CCDS27810.1
International Mouse Phenotyping Consortium Status Dhh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023000 Ensembl Gene Model | MGI Sequence Detail 5510 C57BL/6J ±  kb
transcript ENSMUST00000023737 Ensembl | MGI Sequence Detail 2363 Not Applicable 
polypeptide ENSMUSP00000023737 Ensembl | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(5) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028992 Hedgehog/Intein (Hint) domain
InterPro IPR000320 Hedgehog, N-terminal signalling domain
InterPro IPR001657 Hedgehog protein
InterPro IPR001767 Hedgehog protein, Hint domain
InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
InterPro IPR003586 Hint domain C-terminal
InterPro IPR003587 Hint domain N-terminal
InterPro IPR006141 Intein N-terminal splicing region
Protein Ontology PR:000006459 desert hedgehog protein
References
(Earliest) J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
(Latest) J:222787 Liu C, et al., Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nat Commun. 2015;6:6934
All references(122)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-8842, MGI:2146288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory