Dhh
Gene Detail

Symbol Name ID

Dhh desert hedgehog MGI:94891

Feature Type

protein coding gene

Genetic Map

Chromosome 15

55.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:98893031-98898540 bp, - strand From Ensembl annotation of GRCm38   5510 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22431  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: hedgehog protein
Gene Tree: Dhh

Human homologs

Human Homolog		DHH, desert hedgehog
NCBI Gene ID		50846
neXtProt AC		NX_O43323
Human Synonyms		GDXYM, HHG-3, SRXY7
Human Chr (Location)		12q13.1; chr12:49483204-49488602 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DHH

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds.

 
Human Diseases Modeled Using Mouse Dhh (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell-cell signaling, cell communication, ...
Component	extracellular region, membrane, ...
Function	calcium ion binding, hydrolase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (67 records)
Data Summary: Results (291)    Tissues (137)    Images (32)
Theiler Stages: 2, 3, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	106
Northern blot	1
RT-PCR	184

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(2) cDNA(12) Primer pair(5) Other(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000023000 (Evidence)
Entrez Gene	13363 (Evidence)
DFCI	TC1583773, TC1596210, TC1625014
DoTS	DT.101149458, DT.524934, DT.94168087, DT.99851652
NIA Mouse Gene Index	U036637
Consensus CDS Project	CCDS27810.1
International Mouse Knockout Project Status	Dhh

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023000	Ensembl Gene Model | MGI Sequence Detail	5510	C57BL/6J
transcript	ENSMUST00000023737	Ensembl | MGI Sequence Detail	2363	Not Applicable
polypeptide	ENSMUSP00000023737	Ensembl | MGI Sequence Detail	396	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000320	Hedgehog, N-terminal signaling domain
InterPro	IPR001657	Hedgehog protein
InterPro	IPR009045	Hedgehog signalling/DD-peptidase zinc-binding domain
InterPro	IPR001767	Hint domain
InterPro	IPR003586	Hint domain C-terminal
InterPro	IPR003587	Hint domain N-terminal
InterPro	IPR006141	Intein splice site
Protein Ontology	PR:000006459	desert hedgehog protein

References

(Earliest) J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
(Latest) J:193678 Furmanski AL, et al., Tissue-derived hedgehog proteins modulate th differentiation and disease. J Immunol. 2013 Mar 15;190(6):2641-9
All references(113)

Other accession IDs

MGD-MRK-8842, MGI:2146288