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Dhh Gene Detail
Summary
  • Symbol
    Dhh
  • Name
    desert hedgehog
  • Feature Type
    protein coding gene
  • IDs
    MGI:94891
    NCBI Gene: 13363
  • Gene Overview
    MyGene.info: DHH
Location & Maps
more
  • Sequence Map
    Chr15:98893031-98898540 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5510 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 55.05 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DHH, desert hedgehog
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DHH, desert hedgehog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDXYM, HHG-3, SRXY7
  • Links
    NCBI Gene ID: 50846
    neXtProt AC: NX_O43323

  • Chr Location
    12q13.1; chr12:49089421-49094819 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dhh mouse models; 2 with human DHH associations

Human Disease Mouse Models
       46,xy Gonadal Dysgenesis, Partial, with Minifascicular Neuropathy   OMIM: 607080 View 1 model
       46,xy Sex Reversal 7; SRXY7   OMIM: 233420
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 1 allele in 4 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Dhh
  • Incidental Mutations
    APF
Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023000 Ensembl Gene Model | MGI Sequence Detail 5510 C57BL/6J ±  kb
transcript ENSMUST00000023737 Ensembl | MGI Sequence Detail 2363 Not Applicable  
polypeptide ENSMUSP00000023737 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    25 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 2
    cDNA 13
    Primer pair 6
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-8842, MGI:2146288
References
more
  • Summaries
    All 124
    Developmental Gene Expression 79
    Diseases 2
    Gene Ontology 8
    Phenotypes 36
  • Earliest
    J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
  • Latest
    J:233841 Inoue M, et al., Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice. Endocrinology. 2016 Mar;157(3):1222-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory