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Dhh
Gene Detail
 Symbol
Name
ID
Dhh
desert hedgehog
MGI:94891
Feature Type protein coding gene
Genetic Map
Chromosome 15
55.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:98893031-98898540 bp, - strand
From Ensembl annotation of GRCm38

  5510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22431  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: hedgehog protein
Gene Tree: Dhh

Human
homologs
Human Homolog DHH, desert hedgehog
NCBI Gene ID 50846
neXtProt AC  NX_O43323
Human Synonyms  GDXYM, HHG-3, SRXY7
Human Chr (Location)  12q13.1; chr12:49089421-49094819 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DHH
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds.
 
Human Diseases Modeled Using Mouse Dhh (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell-cell signaling, cell communication, ...
Component extracellular region, membrane, ...
Function calcium ion binding, hydrolase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (292)    Tissues (137)    Images (33)
Theiler Stages: 2, 3, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 107
Northern blot 1
RT-PCR 184
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(13) Primer pair(6) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000023000 (Evidence)
Entrez Gene13363 (Evidence)
DFCITC1583773, TC1596210, TC1625014
DoTSDT.101149458, DT.524934, DT.94168087, DT.99851652
NIA Mouse Gene IndexU036637
Consensus CDS ProjectCCDS27810.1
International Mouse Knockout Project StatusDhh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023000 Ensembl Gene Model | MGI Sequence Detail 5510 C57BL/6J ±  kb
transcript ENSMUST00000023737 Ensembl | MGI Sequence Detail 2363 Not Applicable 
polypeptide ENSMUSP00000023737 Ensembl | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000320 Hedgehog, N-terminal signaling domain
InterPro IPR001657 Hedgehog protein
InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
InterPro IPR001767 Hint domain
InterPro IPR003586 Hint domain C-terminal
InterPro IPR003587 Hint domain N-terminal
InterPro IPR006141 Intein splice site
Protein Ontology PR:000006459 desert hedgehog protein
References (Earliest) J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
(Latest) J:194489 Chen SR, et al., The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
All references(114)
Other
accession IDs
MGD-MRK-8842, MGI:2146288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory