About   Help   FAQ
Dhhtm1Amc
Targeted Allele Detail
Summary
Symbol: Dhhtm1Amc
Name: desert hedgehog; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1934259
Synonyms: Dhh-
Gene: Dhh  Location: Chr15:98789033-98796421 bp, - strand  Genetic Position: Chr15, 55.05 cM
Alliance: Dhhtm1Amc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57914
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2 and part of 3 were replaced with a neomycin cassette. The deleted segments encode a conserved polypeptide required for protein function. Thus, no functional protein is predicted to be produced from this allele. (J:57914)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dhh Mutation:  23 strains or lines available
References
Original:  J:57914 Bitgood MJ, et al., Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol. 1996 Mar 1;6(3):298-304
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/28/2024
MGI 6.13
The Jackson Laboratory