About   Help   FAQ
Dao
Gene Detail
Symbol

Name
ID
Dao
D-amino acid oxidase
MGI:94859
Synonyms
DAO, Dao1, Dao-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:114003703-114025449 bp, + strand
From VEGA annotation of GRCm38

  21747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: DAO
Protein SuperFamily: D-aa_oxidase
Gene Tree: Dao

Human
homologs
DAO, D-amino-acid oxidase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1610
neXtProt AC: NX_P14920

Human Synonyms: DAAO, DAMOX, OXDA

Human Chr (Location): 12q24; chr12:108880030-108901043 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DAO

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased levels of D-serine and a decrease in the severity of behavioral effects induced by NMDA receptor antagonists.
 
Interactions
Dao interacts with 84 markers (Mir25, Mir30b, Mir32, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process D-alanine catabolic process, D-amino acid metabolic process, ...
Component cytosol, mitochondrial outer membrane, ...
Function cofactor binding, D-amino-acid oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (100)    Tissues (95)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dao ; ZFIN dao.1, dao.2, dao.3    NEW 
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024124 (Evidence)
Ensembl Gene Model ENSMUSG00000042096 (Evidence)
Entrez Gene 13142 (Evidence)
UniGene 20115
DFCI TC1583330, TC1591191, TC1695317, TC1716036
DoTS DT.101343757, DT.490442, DT.94202268, DT.97383731
NIA Mouse Gene Index U006022
EC 1.4.3.3
PDB 2DXO
Consensus CDS Project CCDS19557.1, CCDS71641.1
International Mouse Phenotyping Consortium Status Dao
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024124 VEGA Gene Model | MGI Sequence Detail 21747 C57BL/6J ±  kb
transcript OTTMUST00000059023 VEGA | MGI Sequence Detail 1824 Not Applicable 
polypeptide OTTMUSP00000028673 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(308 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023209 D-amino-acid oxidase
InterPro IPR006181 D-amino acid oxidase, conserved site
InterPro IPR006076 FAD dependent oxidoreductase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000006272 D-amino-acid oxidase
References
(Earliest) J:5771 Holmes RS, Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2. Biochem Genet. 1976 Dec;14(11-12):981-7
(Latest) J:182537 Nakamura H, et al., Protective Role of D-Amino Acid Oxidase against Staphylococcus aureus Infection. Infect Immun. 2012 Apr;80(4):1546-53
All references(67)
Other
accession IDs
MGD-MRK-8794, MGD-MRK-8795, MGI:2141010

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory