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Dao Gene Detail
Summary
  • Symbol
    Dao
  • Name
    D-amino acid oxidase
  • Synonyms
    DAO, Dao1, Dao-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94859
    NCBI Gene: 13142
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114003703-114025682 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.93 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94859
protein coding gene Chr5:113999637-114025682 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029928
protein coding gene Chr5:116713832-116736391 (+)
A/J MGP_AJ_G0029893
protein coding gene Chr5:112131049-112154067 (+)
AKR/J MGP_AKRJ_G0029831
protein coding gene Chr5:115699833-115716593 (+)
BALB/cJ MGP_BALBcJ_G0029904
protein coding gene Chr5:113498050-113521432 (+)
C3H/HeJ MGP_C3HHeJ_G0029624
protein coding gene Chr5:116177743-116204782 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030358
protein coding gene Chr5:121226249-121250237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027586
protein coding gene Chr5:106955100-106979819 (+)
CAST/EiJ MGP_CASTEiJ_G0029032
protein coding gene Chr5:115105069-115131241 (+)
CBA/J MGP_CBAJ_G0029591
protein coding gene Chr5:125805914-125834449 (+)
DBA/2J MGP_DBA2J_G0029741
protein coding gene Chr5:112190369-112214238 (+)
FVB/NJ MGP_FVBNJ_G0029698
protein coding gene Chr5:110981531-111003451 (+)
LP/J MGP_LPJ_G0029830
protein coding gene Chr5:117273146-117298741 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029729
protein coding gene Chr5:130299475-130323611 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030399
protein coding gene Chr5:115143564-115172377 (+)
PWK/PhJ MGP_PWKPhJ_G0028746
protein coding gene Chr5:110820085-110843402 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028584
protein coding gene Chr5:112686391-112714181 (+)
WSB/EiJ MGP_WSBEiJ_G0029108
protein coding gene Chr5:115711221-115738458 (+)



Homology
more
  • Human Ortholog
    DAO, D-amino acid oxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAO, D-amino acid oxidase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DAAO, DAMOX, OXDA
  • Links
    NCBI Gene ID: 1610
    neXtProt AC: NX_P14920
    UniProt: P14920

  • Chr Location
    12q24.11; chr12:108880073-108901043 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased levels of D-serine and a decrease in the severity of behavioral effects induced by NMDA receptor antagonists.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042096 Ensembl Gene Model | MGI Sequence Detail 21980 C57BL/6J ±  kb
    transcript ENSMUST00000112292 Ensembl | MGI Sequence Detail 2057 Not Applicable  
    polypeptide ENSMUSP00000107911 Ensembl | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8794, MGD-MRK-8795, MGI:2141010
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:252623 Kondori NR, et al., Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. PLoS One. 2017;12(12):e0188912

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory