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Ldb1
Gene Detail
Symbol

Name
ID
Ldb1
LIM domain binding 1
MGI:894762
STS
Synonyms
CLIM2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:46032593-46045214 bp, - strand
From VEGA annotation of GRCm38

  12622 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LIM-domain-binding protein
Gene Tree: Ldb1

Human
homologs
Human Homolog LDB1, LIM domain binding 1
NCBI Gene ID 8861
neXtProt AC  NX_Q86U70
Human Synonyms  CLIM2, NLI
Human Chr (Location)  10q24-q25; chr10:102106558-102120453 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(104) : Gene trapped(97) Targeted(7)
Genomic Mutations involving Ldb1 (1)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die as embryos at E9.5-E10 with impaired primitive erythropoiesis and vascular development.
 
Human Diseases Modeled Using Mouse Ldb1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ldb1 interacts with 148 markers (Mir1b, Mir18, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process anterior/posterior axis specification, cellular component assembly, ...
Component nuclear chromatin, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (185)    Tissues (140)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 167
Northern blot 8
RT-PCR 10
cDNA source data(158)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(170) Genomic(7) cDNA(159) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033442 (Evidence)
Ensembl Gene ModelENSMUSG00000025223 (Evidence)
Entrez Gene16825 (Evidence)
UniGene327442
DFCITC1680074, TC1574246
DoTSDT.55111705, DT.535469, DT.101408784
NIA Mouse Gene IndexU039101
PDB2L6Z, 1J2O, 1M3V, 2L6Y, 2JTN, 1RUT, 4JCJ, 2LXD
Consensus CDS ProjectCCDS29870.1, CCDS50455.1
International Mouse Knockout Project StatusLdb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033442 VEGA Gene Model | MGI Sequence Detail 12622 C57BL/6J ±  kb
transcript OTTMUST00000084014 VEGA | MGI Sequence Detail 2014 Not Applicable 
polypeptide OTTMUSP00000045212 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002691 LIM-domain binding protein
Protein Ontology PR:000009736 LIM domain-binding protein 1
References
(Earliest) J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
(Latest) J:215517 Cross SH, et al., A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LBD1-mediated dimerisation. PLoS Genet. 2014 May;10(5):e1004359
All references(90)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory