About   Help   FAQ
Ldb1
Gene Detail
 Symbol
Name
ID
Ldb1
LIM domain binding 1
MGI:894762
STS A116
Synonyms CLIM2
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:46032593-46045214 bp, - strand
From VEGA annotation of GRCm38

  12622 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LIM-domain-binding protein
Gene Tree: Ldb1

Human
homologs
Human Homolog LDB1, LIM domain binding 1
NCBI Gene ID 8861
neXtProt AC  NX_Q86U70
Human Synonyms  CLIM2, NLI
Human Chr (Location)  10q24-q25; chr10:102106558-102120453 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(104) : Gene trapped(97) Targeted(7)
Genomic Mutations involving Ldb1 (1)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die as embryos at E9.5-E10 with impaired primitive erythropoiesis and vascular development.
 
Human Diseases Modeled Using Mouse Ldb1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ldb1 interacts with 148 markers (Mir1b, Mir18, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process anterior/posterior axis specification, cellular component assembly, ...
Component nuclear chromatin, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (185)    Tissues (130)    Images (44)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 167
Northern blot 8
RT-PCR 10
cDNA source data(158)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(170) Genomic(7) cDNA(159) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033442 (Evidence)
Ensembl Gene ModelENSMUSG00000025223 (Evidence)
Entrez Gene16825 (Evidence)
UniGene327442
DFCITC1574246, TC1680074
DoTSDT.101408784, DT.535469, DT.55111705
NIA Mouse Gene IndexU039101
PDB1J2O, 1M3V, 1RUT, 2JTN, 2L6Y, 2L6Z, 2LXD, 4JCJ
Consensus CDS ProjectCCDS29870.1, CCDS50455.1
International Mouse Knockout Project StatusLdb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033442 VEGA Gene Model | MGI Sequence Detail 12622 C57BL/6J ±  kb
transcript OTTMUST00000084014 VEGA | MGI Sequence Detail 2014 Not Applicable 
polypeptide OTTMUSP00000045212 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(8) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002691 LIM-domain binding protein
Protein Ontology PR:000009736 LIM domain-binding protein 1
References (Earliest) J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
(Latest) J:208345 Almaidhan A, et al., Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Dev Biol. 2014;14:3
All references(87)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory