Ldb1
Gene Detail

Symbol Name ID

Ldb1 LIM domain binding 1 MGI:894762

STS

A116

Synonyms

CLIM2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:46032593-46045214 bp, - strand From VEGA annotation of GRCm38   12622 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LIM-domain-binding protein
Gene Tree: Ldb1

Human homologs

Human Homolog		LDB1, LIM domain binding 1
NCBI Gene ID		8861
neXtProt AC		NX_Q86U70
Human Synonyms		CLIM2, NLI
Human Chr (Location)		10q24-q25; chr10:103867317-103880210 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(102) : Targeted(5) Gene trapped(97)
 

Mice homozygous for disruptions in this gene die as embryos at E9.5-E10.

 
Human Diseases Modeled Using Mouse Ldb1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	anterior/posterior axis specification, cellular component assembly, ...
Component	cell-cell junction, nuclear chromatin, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (31 records)
Data Summary: Results (191)    Tissues (134)    Images (44)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	166
Northern blot	8
RT-PCR	17

cDNA source data(158)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(170) Genomic(7) cDNA(159) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033442 (Evidence)
Ensembl Gene Model	ENSMUSG00000025223 (Evidence)
Entrez Gene	16825 (Evidence)
UniGene	327442
DFCI	TC1574246, TC1680074
DoTS	DT.101408784, DT.535469, DT.55111705
NIA Mouse Gene Index	U039101
PDB	1J2O, 1M3V, 1RUT, 2JTN, 2L6Y, 2L6Z, 2LXD
Consensus CDS Project	CCDS29870.1, CCDS50455.1
International Mouse Knockout Project Status	Ldb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033442	VEGA Gene Model | MGI Sequence Detail	12622	C57BL/6J
transcript	OTTMUST00000084014	VEGA | MGI Sequence Detail	2014	Not Applicable
polypeptide	OTTMUSP00000045212	VEGA | MGI Sequence Detail	411	Not Applicable

All sequences(54) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002691	LIM-domain binding protein
Protein Ontology	PR:000009736	LIM domain-binding protein 1

References

(Earliest) J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
(Latest) J:192057 Song SH, et al., Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation. Biochim Biophys Acta. 2012 Aug;1819(8):885-91
All references(80)