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Ldb1 Gene Detail
Summary
  • Symbol
    Ldb1
  • Name
    LIM domain binding 1
  • Synonyms
    CLIM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894762
    NCBI Gene: 16825
  • Gene Overview
    MyGene.info: LDB1
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46032593-46045214 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.75 cM
  • Mapping Data
    4 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894762
protein coding gene Chr19:46032589-46045515 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025197
protein coding gene Chr19:45689226-45703885 (-)
A/J MGP_AJ_G0025173
protein coding gene Chr19:43442953-43457748 (-)
AKR/J MGP_AKRJ_G0025142
protein coding gene Chr19:44850150-44862798 (-)
BALB/cJ MGP_BALBcJ_G0025168
protein coding gene Chr19:43499714-43513636 (-)
C3H/HeJ MGP_C3HHeJ_G0024928
protein coding gene Chr19:45022667-45036348 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025611
protein coding gene Chr19:46827735-46841077 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023025
protein coding gene Chr19:42681003-42693853 (-)
CAST/EiJ MGP_CASTEiJ_G0024393
protein coding gene Chr19:44793667-44806311 (-)
CBA/J MGP_CBAJ_G0024908
protein coding gene Chr19:49185241-49198514 (-)
DBA/2J MGP_DBA2J_G0025040
protein coding gene Chr19:43262270-43275970 (-)
FVB/NJ MGP_FVBNJ_G0025001
protein coding gene Chr19:43038602-43051879 (-)
LP/J MGP_LPJ_G0025126
protein coding gene Chr19:45599403-45613361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025032
protein coding gene Chr19:48545324-48560474 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025669
protein coding gene Chr19:44955528-44970749 (-)
PWK/PhJ MGP_PWKPhJ_G0024142
protein coding gene Chr19:43192901-43206759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023946
protein coding gene Chr19:43613533-43626348 (-)
WSB/EiJ MGP_WSBEiJ_G0024463
protein coding gene Chr19:45099904-45115910 (-)



Homology
more
  • Human Ortholog
    LDB1, LIM domain binding 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LDB1, LIM domain binding 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLIM2, CLIM-2, LDB-1, NLI
  • Links
    NCBI Gene ID: 8861
    neXtProt AC: NX_Q86U70
    UniProt: Q86U70

  • Chr Location
    10q24.32; chr10:102102100-102120473 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ldb1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos at E9.5-E10 with impaired primitive erythropoiesis and vascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025223 Ensembl Gene Model | MGI Sequence Detail 12622 C57BL/6J ±  kb
    transcript ENSMUST00000156585 Ensembl | MGI Sequence Detail 2014 Not Applicable  
    polypeptide ENSMUSP00000118546 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      Genomic 7
      cDNA 160
      Primer pair 2
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 46
      Diseases 1
      Gene Ontology 27
      Phenotypes 25
    • Earliest
      J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
    • Latest
      J:263985 de Melo J, et al., Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina. Development. 2018 Apr 30;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory