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Ldb1
Gene Detail
Symbol

Name
ID
Ldb1
LIM domain binding 1
MGI:894762
STS
Synonyms
CLIM2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:46032593-46045214 bp, - strand
From VEGA annotation of GRCm38

  12622 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LDB1
Protein SuperFamily: LIM-domain-binding protein
Gene Tree: Ldb1

Human
homologs
LDB1, LIM domain binding 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8861
neXtProt AC: NX_Q86U70

Human Synonyms: CLIM2, NLI

Human Chr (Location): 10q24-q25; chr10:102106558-102120453 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(104) : Gene trapped(97) Targeted(7)
Genomic Mutations involving Ldb1 (1)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die as embryos at E9.5-E10 with impaired primitive erythropoiesis and vascular development.
 
Human Diseases Modeled in Mice Using Ldb1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ldb1 interacts with 147 markers (Mir1b, Mir18, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process anterior/posterior axis specification, cellular component assembly, ...
Component nuclear chromatin, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (185)    Tissues (140)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 167
Northern blot 8
RT-PCR 10
cDNA source data(158)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LDB1 ; Xenbase ldb1 ; ZFIN ldb1a, ldb1b    NEW 
Molecular
reagents
All nucleic(170) Genomic(7) cDNA(159) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033442 (Evidence)
Ensembl Gene Model ENSMUSG00000025223 (Evidence)
Entrez Gene 16825 (Evidence)
UniGene 327442
DFCI TC1680074, TC1574246
DoTS DT.55111705, DT.535469, DT.101408784
NIA Mouse Gene Index U039101
PDB 4JCJ, 1M3V, 2LXD, 1J2O, 1RUT, 2L6Z, 2L6Y, 2JTN
Consensus CDS Project CCDS29870.1, CCDS50455.1
International Mouse Phenotyping Consortium Status Ldb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033442 VEGA Gene Model | MGI Sequence Detail 12622 C57BL/6J ±  kb
transcript OTTMUST00000084014 VEGA | MGI Sequence Detail 2014 Not Applicable 
polypeptide OTTMUSP00000045212 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002691 LIM-domain binding protein
Protein Ontology PR:000009736 LIM domain-binding protein 1
References
(Earliest) J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
(Latest) J:217655 Zhang F, et al., Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1380-5
All references(91)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory