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Galnt3
Gene Detail
Symbol

Name
ID
Galnt3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3
MGI:894695
Synonyms
ppGaNTase-T3
Feature Type
protein coding gene
Genetic Map
Chromosome 2
38.99 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:66082766-66124994 bp, - strand
From VEGA annotation of GRCm38

  42229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GALNT3
Gene Tree: Galnt3

Human
homologs
GALNT3, polypeptide N-acetylgalactosaminyltransferase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2591
neXtProt AC: NX_Q14435

Human Synonyms: GalNAc-T3, HFTC, HHS

Human Chr (Location): 2q24-q31; chr2:165747803-165794650 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased circulating alkaline phosphatase, hypercalcemia, hyperphosphatemia, decreased circulating parathyroid hormone, and male specific postnatal growth retardation, infertility, and increase in bone density.
 
Human Diseases Modeled in Mice Using Galnt3 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Galnt3 interacts with 233 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (102)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000013003 (Evidence)
Ensembl Gene Model ENSMUSG00000026994 (Evidence)
Entrez Gene 14425 (Evidence)
UniGene 439760
DFCI TC1739721, TC1685051, TC1613957, TC1579663
DoTS DT.94251897, DT.91330028, DT.524355
NIA Mouse Gene Index U022693
EC 2.4.1.41
Consensus CDS Project CCDS16075.1
International Mouse Phenotyping Consortium Status Galnt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013003 VEGA Gene Model | MGI Sequence Detail 42229 C57BL/6J ±  kb
transcript OTTMUST00000031330 VEGA | MGI Sequence Detail 3885 Not Applicable 
polypeptide OTTMUSP00000014011 VEGA | MGI Sequence Detail 633 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(388 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001173 Glycosyl transferase, family 2
InterPro IPR000772 Ricin B lectin domain
Protein Ontology PR:000007825 polypeptide N-acetylgalactosaminyltransferase 3
References
(Earliest) J:36626 Zara J, et al., Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3. Biochem Biophys Res Commun. 1996 Nov 1;228(1):38-44
(Latest) J:218346 Ichikawa S, et al., Genetic rescue of glycosylation-deficient Fgf23 in the Galnt3 knockout mouse. Endocrinology. 2014 Oct;155(10):3891-8
All references(41)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory