Galnt3^tm1Mjec
Targeted Allele Detail

Summary

• Symbol: Galnt3^tm1Mjec
• Name: polypeptide N-acetylgalactosaminyltransferase 3; targeted mutation 1, Michael J Econs
• MGI ID: MGI:4355571
• Gene: Galnt3 Location: Chr2:65913110-65955217 bp, - strand Genetic Position: Chr2, 38.99 cM, cytoband C3
• Alliance: Galnt3^tm1Mjec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151805
• Parent Cell Line: CCE916 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with an loxP-flanked neo cassette. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:151805)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Galnt3 Mutation: 29 strains or lines available

References

• Original: J:151805 Ichikawa S, et al., Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. Endocrinology. 2009 Jun;150(6):2543-50
• All: 8 reference(s)