All Phenotypes Galnt3<tm1Mjec> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Galnt3^tm1Mjec
targeted mutation 1, Michael J Econs
MGI:4355571

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Galnt3^tm1Mjec/Galnt3^tm1Mjec	involves: 129S/SvEv * C57BL/6J	MGI:4355581
ht2	Galnt3^tm1Mjec/Galnt3⁺	involves: 129S/SvEv * C57BL/6J	MGI:4355582

Allelic Composition	Galnt3^tm1Mjec/Galnt3^tm1Mjec
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galnt3^tm1Mjec mutation (1 available); any Galnt3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:151805 )

• seminiferous tubules contain less spermatozoa than in wild-type mice

teratozoospermia ( J:151805 )

small seminiferous tubules ( J:151805 )

• narrow

male infertility ( J:151805 )

homeostasis/metabolism

decreased circulating parathyroid hormone level ( J:151805 )

• at 12 weeks

increased circulating calcium level ( J:151805 )

• at 6 weeks

increased circulating phosphate level ( J:151805 )

• at 3, 6, and 12 weeks

decreased circulating alkaline phosphatase level ( J:151805 )

• at 3, 6, and 12 weeks

abnormal vitamin D level ( J:151805 )

• at 24 weeks, 1,25-dihydroxyvitamin D levels are inappropriately normal in the face of predicted hyperposphatemia

skeleton

abnormal femur morphology ( J:151805 )

• denser than normal by ex vivo radiography in male mice

increased bone mineral density ( J:151805 )

• in males but not females

growth/size/body

postnatal growth retardation ( J:151805 )

• in males but not females

limbs/digits/tail

abnormal femur morphology ( J:151805 )

• denser than normal by ex vivo radiography in male mice

endocrine/exocrine glands

small seminiferous tubules ( J:151805 )

• narrow

cellular

oligozoospermia ( J:151805 )

• seminiferous tubules contain less spermatozoa than in wild-type mice

teratozoospermia ( J:151805 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperphosphatemic familial tumoral calcinosis		DOID:0111063	OMIM:211900	J:151805

Allelic Composition	Galnt3^tm1Mjec/Galnt3⁺
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galnt3^tm1Mjec mutation (1 available); any Galnt3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:151805 )

• in males but not females

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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