Mtr
Gene Detail

Symbol Name ID

Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase MGI:894292

Synonyms

D830038K18Rik, methionine synthase, MS

Feature Type

protein coding gene

Genetic Map

Chromosome 13

4.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:12186542-12258113 bp, - strand From Ensembl annotation of GRCm38   71572 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cobalamin-dependent methionine synthase
Gene Tree: Mtr

Human homologs

Human Homolog		MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase
NCBI Gene ID		4548
neXtProt AC		NX_Q99707
Human Synonyms		cblG, MS
Human Chr (Location)		1q43; chr1:236958581-237067281 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MTR

Alleles and phenotypes

All alleles(13) : Targeted(3) Gene trapped(10)
 

Mice homozygous for a targeted null mutation exhibit embryonic lethality prior to E9.5. Heterozygous appear mostly similar to conrtols, except that they exhibit elevated plasma methionine and homocysteine levels.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cellular amino acid biosynthetic process, cellular metabolic process, ...
Component	cytoplasm, intracellular
Function	amino acid binding, cobalamin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (116)    Tissues (97)    Images (8)
Theiler Stages: 15, 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	16
RT-PCR	6

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(28) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000021311 (Evidence)
Entrez Gene	238505 (Evidence)
UniGene	40335
DFCI	TC1619029, TC1626244, TC1628014
DoTS	DT.40148488, DT.40171468, DT.521756
NIA Mouse Gene Index	U034511
EC	2.1.1.13
Consensus CDS Project	CCDS36591.1
International Mouse Knockout Project Status	Mtr

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021311	Ensembl Gene Model | MGI Sequence Detail	71572	C57BL/6J
transcript	ENSMUST00000099856	Ensembl | MGI Sequence Detail	4482	Not Applicable
polypeptide	ENSMUSP00000097442	Ensembl | MGI Sequence Detail	1253	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(465 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011822	5-methyltetrahydrofolate--homocysteine methyltransferase
InterPro	IPR006158	Cobalamin (vitamin B12)-binding
InterPro	IPR003759	Cobalamin (vitamin B12)-binding module, cap domain
InterPro	IPR011005	Dihydropteroate synthase-like
InterPro	IPR003726	Homocysteine S-methyltransferase
InterPro	IPR000489	Pterin-binding
InterPro	IPR004223	Vitamin B12-dependent methionine synthase, activation domain
Protein Ontology	PR:000010747	methionine synthase

References

(Earliest) J:39061 Zhang ZX, et al., The methionine synthase (Mtr) gene maps to proximal mouse chromosome 13. Mamm Genome. 1997 Oct;8(10):787-8
(Latest) J:184371 Cherukad J, et al., Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development. Placenta. 2012 May;33(5):440-8
All references(42)

Other accession IDs

MGI:2139114