About   Help   FAQ
Mtr
Gene Detail
 Symbol
Name
ID
Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
MGI:894292
Synonyms D830038K18Rik, methionine synthase, MS
Feature Type protein coding gene
Genetic Map
Chromosome 13
4.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:12186542-12258113 bp, - strand
From Ensembl annotation of GRCm38

  71572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cobalamin-dependent methionine synthase
Gene Tree: Mtr

Human
homologs
Human Homolog MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase
NCBI Gene ID 4548
neXtProt AC  NX_Q99707
Human Synonyms  cblG, HMAG, MS
Human Chr (Location)  1q43; chr1:236795281-236903981 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MTR
Alleles
and
phenotypes
All alleles(14) : Targeted(4) Gene trapped(10)
 
Mice homozygous for a targeted null mutation exhibit embryonic lethality prior to E9.5. Heterozygous appear mostly similar to conrtols, except that they exhibit elevated plasma methionine and homocysteine levels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular amino acid biosynthetic process, cellular metabolic process, ...
Component cytoplasm, intracellular
Function amino acid binding, cobalamin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (116)    Tissues (97)    Images (8)
Theiler Stages: 15, 22, 28
Assay TypeResults
RNA in situ 94
Northern blot 16
RT-PCR 6
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) cDNA(28) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000021311 (Evidence)
Entrez Gene238505 (Evidence)
UniGene40335
DFCITC1619029, TC1626244, TC1628014
DoTSDT.40148488, DT.40171468, DT.521756
NIA Mouse Gene IndexU034511
EC2.1.1.13
Consensus CDS ProjectCCDS36591.1
International Mouse Knockout Project StatusMtr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021311 Ensembl Gene Model | MGI Sequence Detail 71572 C57BL/6J ±  kb
transcript ENSMUST00000099856 Ensembl | MGI Sequence Detail 4482 Not Applicable 
polypeptide ENSMUSP00000097442 Ensembl | MGI Sequence Detail 1253 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(489 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011822 5-methyltetrahydrofolate--homocysteine methyltransferase
InterPro IPR006158 Cobalamin (vitamin B12)-binding domain
InterPro IPR003759 Cobalamin (vitamin B12)-binding module, cap domain
InterPro IPR011005 Dihydropteroate synthase-like
InterPro IPR003726 Homocysteine S-methyltransferase
InterPro IPR000489 Pterin-binding
InterPro IPR004223 Vitamin B12-dependent methionine synthase, activation domain
Protein Ontology PR:000010747 methionine synthase
References (Earliest) J:39061 Zhang ZX, et al., The methionine synthase (Mtr) gene maps to proximal mouse chromosome 13. Mamm Genome. 1997 Oct;8(10):787-8
(Latest) J:184371 Cherukad J, et al., Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development. Placenta. 2012 May;33(5):440-8
All references(42)
Other
accession IDs
MGI:2139114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory