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Sepp1
Gene Detail
Symbol

Name
ID
Sepp1
selenoprotein P, plasma, 1
MGI:894288
Synonyms
D15Ucla1, selp, Se-P
Feature Type
protein coding gene
Genetic Map
Chromosome 15
1.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:3268547-3280507 bp, + strand
From VEGA annotation of GRCm38

  11961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEPP1
Protein SuperFamily: selenoprotein P
Gene Tree: Sepp1

Human
homologs
SEPP1, selenoprotein P, plasma, 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6414
neXtProt AC: NX_P49908

Human Synonyms: SELP, SeP, SEPP

Human Chr (Location): 5q31; chr5:42799880-42811922 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit ataxia, spasticity, impaired growth, reduced male fertility, and excess mortality.
 
Phenotype Images(2)
Interactions
Sepp1 interacts with 152 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process brain development, growth, ...
Component extracellular exosome, extracellular region, ...
Function selenium binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (262)    Tissues (188)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 191
Northern blot 33
RT-PCR 38
cDNA source data(653)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sepp1 ; ZFIN sepp1a    NEW 
Molecular
reagents
All nucleic(657) cDNA(653) Primer pair(2) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000035135 (Evidence)
Ensembl Gene Model ENSMUSG00000064373 (Evidence)
Entrez Gene 20363 (Evidence)
UniGene 392203
DFCI TC1573684, TC1601761, TC1634616, TC1641939, TC1687986
DoTS DT.101318727, DT.101318738, DT.60118590, DT.91359432, DT.94330907, DT.97391493, DT.97391504
NIA Mouse Gene Index U016008
Consensus CDS Project CCDS27357.1
International Mouse Phenotyping Consortium Status Sepp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035135 VEGA Gene Model | MGI Sequence Detail 11961 C57BL/6J ±  kb
transcript OTTMUST00000089456 VEGA | MGI Sequence Detail 2084 Not Applicable 
polypeptide OTTMUSP00000048887 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007672 Selenoprotein P, C-terminal
InterPro IPR007671 Selenoprotein P, N-terminal
Protein Ontology PR:000014646 selenoprotein P
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:219003 Hill KE, et al., Selenoprotein P is the major selenium transport protein in mouse milk. PLoS One. 2014;9(7):e103486
All references(79)
Other
accession IDs
MGD-MRK-4226, MGI:2146129, MGI:90427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory