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Sstr5 Gene Detail
Summary
  • Symbol
    Sstr5
  • Name
    somatostatin receptor 5
  • Synonyms
    Smstr5, sst5
  • Feature Type
    protein coding gene
  • IDs
    MGI:894282
    NCBI Gene: 20609
  • Gene Overview
    MyGene.info: SSTR5
Location & Maps
more
  • Sequence Map
    Chr17:25489875-25497288 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SSTR5, somatostatin receptor 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SSTR5, somatostatin receptor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SS-5-R
  • Links
    NCBI Gene ID: 6755
    neXtProt AC: NX_P35346

  • Chr Location
    16p13.3; chr16:1072756-1081454 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SSTR5 associations

Human Disease Mouse Models
       Somatostatin Receptor 5; SSTR5   OMIM: 182455
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Sstr5
  • Incidental Mutations
Homozygotes for one null allele display decreased numbers of insulin positive cells in the pancreas. Homozygotes for a second null allele have normal pancreatic islet morphology but increased insulin secretion, decreased blood insulin and glucose levels,and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050824 Ensembl Gene Model | MGI Sequence Detail 7414 C57BL/6J ±  kb
transcript ENSMUST00000165183 Ensembl | MGI Sequence Detail 2581 Not Applicable  
polypeptide ENSMUSP00000128787 Ensembl | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    265 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 10
    Genomic 4
    cDNA 5
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:41656 Brinkmeier ML, et al., Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs. Genomics. 1997 Jul 1;43(1):9-14
  • Latest
    J:212946 Bauch C, et al., Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins. PLoS One. 2014;9(2):e88529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory