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Sstr5 Gene Detail
Summary
  • Symbol
    Sstr5
  • Name
    somatostatin receptor 5
  • Synonyms
    Smstr5, sst5
Location &
Maps
more
  • Sequence Map
    Chr17:25708849-25716262 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894282
 protein coding gene Chr17:25708847-25733577 (-)
129S1/SvImJ ENSMUSG00200052615
 protein coding gene Chr17:21153815-21161231 (-)
A/J ENSMUSG00195052213
 protein coding gene Chr17:22171441-22178857 (-)
AKR/J ENSMUSG00220053315
 protein coding gene Chr17:21216465-21223878 (-)
BALB/cJ ENSMUSG00180049086
 protein coding gene Chr17:21451825-21459241 (-)
C3H/HeJ ENSMUSG00175051816
 protein coding gene Chr17:21210429-21217845 (-)
C57BL/6NJ ENSMUSG00215054195
 protein coding gene Chr17:21217179-21224592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021239
 protein coding gene Chr17:21323477-21331104 (-)
CAST/EiJ ENSTCUG00005044718
 protein coding gene Chr17:21796179-21803595 (-)
CBA/J ENSMUSG00210045823
 protein coding gene Chr17:21049264-21056680 (-)
DBA/2J ENSMUSG00185043828
 protein coding gene Chr17:23259698-23267114 (-)
FVB/NJ ENSMUSG00205051411
 protein coding gene Chr17:21514860-21522276 (-)
JF1/MsJ ENSUMUG00000017397
 protein coding gene Chr17:22708731-22716144 (-)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190036504
 protein coding gene Chr17:21148419-21155835 (-)
NZO/HlLtJ ENSMUSG00225051189
 protein coding gene Chr17:26578787-26586203 (-)
PWK/PhJ ENSLUMG00010053226
 protein coding gene Chr17:20626092-20633487 (-)
SPRET/EiJ ENSMSPG00010045384
 protein coding gene Chr17:21951179-21958530 (-)
WSB/EiJ ENSIUOG00005050668
 protein coding gene Chr17:21891383-21898793 (-)



Homology
more
  • Human Ortholog
    SSTR5, somatostatin receptor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSTR5, somatostatin receptor 5
  • Synonyms
    SS-5-R, SST5
  • Links
    NCBI Gene ID: 6755
    UniProt: P35346

  • Chr Location
    16p13.3; chr16:1063867-1081467 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SSTR5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele display decreased numbers of insulin positive cells in the pancreas. Homozygotes for a second null allele have normal pancreatic islet morphology but increased insulin secretion, decreased blood insulin and glucose levels,and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    7
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20609 NCBI Gene Model | MGI Sequence Detail 7414 C57BL/6J ±  kb
    transcript NM_011425 RefSeq | MGI Sequence Detail 2733 C57BL/6  
    polypeptide O08858 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 4
      cDNA 6
      Primer pair 3
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:41656 Brinkmeier ML, et al., Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs. Genomics. 1997 Jul 1;43(1):9-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory