Sstr5
Gene Detail

Symbol Name ID

Sstr5 somatostatin receptor 5 MGI:894282

Synonyms

Smstr5, sst5

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:25489875-25497288 bp, - strand From NCBI annotation of GRCm38   7414 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20287  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: somatostatin receptor
Gene Tree: Sstr5

Human homologs

Human Homolog		SSTR5, somatostatin receptor 5
NCBI Gene ID		6755
neXtProt AC		NX_P35346
Human Synonyms		SS-5-R
Human Chr (Location)		16p13.3; chr16:1122756-1131454 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SSTR5

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for one null allele display decreased numbers of insulin positive cells in the pancreas. Homozygotes for a second null allele have normal pancreatic islet morphology but increased insulin secretion, decreased blood insulin and glucose levels, and improved glucose tolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, glucose homeostasis, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) Genomic(4) cDNA(5) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000050824 (Evidence)
Entrez Gene	20609 (Evidence)
DFCI	TC1588294
DoTS	DT.55251618, DT.94135256
NIA Mouse Gene Index	U049078
Consensus CDS Project	CCDS28520.1
International Mouse Knockout Project Status	Sstr5

Sequences

Length	Strain/Species
genomic	20609	NCBI Gene Model | MGI Sequence Detail	7414	C57BL/6J
transcript	NM_011425	RefSeq | MGI Sequence Detail	2733	C57BL/6
polypeptide	O08858	UniProt | EBI | MGI Sequence Detail	362	Not Applicable

All sequences(29) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000586	Somatostatin receptor
InterPro	IPR001184	Somatostatin receptor, type 5
Protein Ontology	PR:000001672	somatostatin receptor 5

Graphical View of Protein Domain Structure

References

(Earliest) J:41656 Brinkmeier ML, et al., Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs. Genomics. 1997 Jul 1;43(1):9-14
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(46)