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Prl8a2 Gene Detail
Summary
  • Symbol
    Prl8a2
  • Name
    prolactin family 8, subfamily a, member 2
  • Synonyms
    DPRP, Dtprp, D/tPRP, mdPRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:894281
    NCBI Gene: 13529
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:27345673-27354216 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.41 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894281
protein coding gene Chr13:27345673-27354216 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020396
protein coding gene Chr13:24964506-24975492 (+)
A/J MGP_AJ_G0020347
protein coding gene Chr13:24424701-24433029 (+)
AKR/J MGP_AKRJ_G0020327
protein coding gene Chr13:24780406-24788835 (+)
BALB/cJ MGP_BALBcJ_G0020345
protein coding gene Chr13:24434662-24447296 (+)
C3H/HeJ MGP_C3HHeJ_G0020148
protein coding gene Chr13:24842559-24852873 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020782
protein coding gene Chr13:25846334-25856420 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018367
protein coding gene Chr13:23061982-23070778 (+)
CAST/EiJ MGP_CASTEiJ_G0019666
protein coding gene Chr13:24538322-24548965 (+)
CBA/J MGP_CBAJ_G0020102
protein coding gene Chr13:26908551-26918991 (+)
DBA/2J MGP_DBA2J_G0020226
protein coding gene Chr13:23972989-23985288 (+)
FVB/NJ MGP_FVBNJ_G0020212
protein coding gene Chr13:23571054-23581013 (+)
LP/J MGP_LPJ_G0020302
protein coding gene Chr13:25233165-25242700 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020240
protein coding gene Chr13:27188218-27208720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020822
protein coding gene Chr13:24620097-24628245 (+)
PWK/PhJ MGP_PWKPhJ_G0019420
protein coding gene Chr13:23873429-23882224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019236
protein coding gene Chr13:23520633-23528926 (+)
WSB/EiJ MGP_WSBEiJ_G0019726
protein coding gene Chr13:24792907-24809743 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced pregnancy success when exposed to hypoxic conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13529 NCBI Gene Model | MGI Sequence Detail 8544 C57BL/6J ±  kb
    transcript NM_010088 RefSeq | MGI Sequence Detail 939 C57BL/6  
    polypeptide NP_034218 RefSeq | MGI Sequence Detail 240 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR009079 Four-helical cytokine-like, core
      IPR001400 Somatotropin/prolactin
    Molecular
    Reagents
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    • All nucleic 128
      Genomic 1
      cDNA 122
      Primer pair 4
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:240175 Kelleher AM, et al., Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Proc Natl Acad Sci U S A. 2017 Feb 07;114(6):E1018-E1026

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory