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Neurog3
Gene Detail
 Symbol
Name
ID
Neurog3
neurogenin 3
MGI:893591
Synonyms Atoh5, bHLHa7, Math4B, ngn3
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.35 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:62133090-62134763 bp, + strand
From NCBI annotation of GRCm38

  1674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Neurog3

Human
homologs
Human Homolog NEUROG3, neurogenin 3
NCBI Gene ID 50674
neXtProt AC  NX_Q9Y4Z2
Human Synonyms  Atoh5, bHLHa7, Math4B, ngn3, NGN-3
Human Chr (Location)  10q21.3; chr10:69572035-69573454 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NEUROG3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
 
Homozygotes for targeted null mutations are deficient in endocrine cells of the glandular stomach and intestinal epithelium, and lack glucagon- and insulin-producing cells of the pancreas. Mutants die postnatally from diabetes.
 
Interactions
Neurog3 interacts with 109 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell differentiation, epithelial cell differentiation, ...
Component cytoplasm, intracellular, ...
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (204 records)
Data Summary: Results (475)    Tissues (269)    Images (187)
Theiler Stages: 2, 3, 4, 5, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 85
RNA in situ 345
Northern blot 2
RT-PCR 43
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(3) cDNA(15) Primer pair(10) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000044312 (Evidence)
Entrez Gene11925 (Evidence)
DFCITC1592863, TC1679257
DoTSDT.110630064, DT.55279098
NIA Mouse Gene IndexU011576
Consensus CDS ProjectCCDS23887.1
International Mouse Knockout Project StatusNeurog3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11925 NCBI Gene Model | MGI Sequence Detail 1674 C57BL/6J ±  kb
transcript NM_009719 RefSeq | MGI Sequence Detail 1540 C57BL/6 
polypeptide P70661 UniProt | EBI | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000011158 neurogenin-3
Graphical View of Protein Domain Structure
References (Earliest) J:38581 Sommer L, et al., neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996;8(4):221-41
(Latest) J:209016 Piccand J, et al., Pak3 promotes cell cycle exit and differentiation of beta-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014 Jan;63(1):203-15
All references(260)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory