Neurog3
Gene Detail

Symbol Name ID

Neurog3 neurogenin 3 MGI:893591

Synonyms

Atoh5, bHLHa7, Math4B, ngn3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

32.35 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:62133090-62134763 bp, + strand From NCBI annotation of GRCm38   1674 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Neurog3

Human homologs

Human Homolog		NEUROG3, neurogenin 3
NCBI Gene ID		50674
neXtProt AC		NX_Q9Y4Z2
Human Synonyms		Atoh5, bHLHa7, Math4B, ngn3, NGN-3
Human Chr (Location)		10q21.3; chr10:71331791-71333210 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NEUROG3

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygotes for targeted null mutations are deficient in endocrine cells of the glandular stomach and intestinal epithelium, and lack glucagon- and insulin-producing cells of the pancreas. Mutants die postnatally from diabetes.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell differentiation, epithelial cell differentiation, ...
Component	cytoplasm, intracellular, ...
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (187 records)
Data Summary: Results (333)    Tissues (201)    Images (115)
Theiler Stages: 2, 3, 4, 5, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	51
RNA in situ	237
Northern blot	2
RT-PCR	43

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(2) cDNA(14) Primer pair(8) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000044312 (Evidence)
Entrez Gene	11925 (Evidence)
UniGene	57236
DFCI	TC1592863, TC1679257
DoTS	DT.110630064, DT.55279098
NIA Mouse Gene Index	U011576
Consensus CDS Project	CCDS23887.1
International Mouse Knockout Project Status	Neurog3

Sequences

Length	Strain/Species
genomic	11925	NCBI Gene Model | MGI Sequence Detail	1674	C57BL/6J
transcript	NM_009719	RefSeq | MGI Sequence Detail	1540	C57BL/6
polypeptide	P70661	UniProt | EBI | MGI Sequence Detail	214	Not Applicable

All sequences(20) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000011158	neurogenin-3

Graphical View of Protein Domain Structure

References

(Earliest) J:38581 Sommer L, et al., neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996;8(4):221-41
(Latest) J:193959 Georgia S, et al., DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15;27(4):372-7
All references(236)