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Neurog3 Gene Detail
Summary
  • Symbol
    Neurog3
  • Name
    neurogenin 3
  • Synonyms
    Atoh5, bHLHa7, Math4B, ngn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:893591
    NCBI Gene: 11925
  • Gene Overview
    MyGene.info: NEUROG3
Location & Maps
more
  • Sequence Map
    Chr10:62133090-62134763 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1674 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.35 cM, cytoband B4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NEUROG3, neurogenin 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NEUROG3, neurogenin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Atoh5, bHLHa7, Math4B, ngn3, NGN-3
  • Links
    NCBI Gene ID: 50674
    neXtProt AC: NX_Q9Y4Z2

  • Chr Location
    10q22.1; chr10:69572035-69573454 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NEUROG3 associations

Human Disease Mouse Models
       Diarrhea 4, Malabsorptive, Congenital; DIAR4   OMIM: 610370
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 8 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    10
  • Transgenic
    2
  • Genomic Mutations
    2 involving Neurog3
Homozygotes for targeted null mutations are deficient in endocrine cells of the glandular stomach and intestinal epithelium, and lack glucagon- and insulin-producing cells of the pancreas. Mutants die postnatally from diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11925 NCBI Gene Model | MGI Sequence Detail 1674 C57BL/6J ±  kb
transcript NM_009719 RefSeq | MGI Sequence Detail 1540 C57BL/6  
polypeptide P70661 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    21 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 3
    cDNA 15
    Primer pair 10
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 288
    Developmental Gene Expression 234
    Gene Ontology 13
    Phenotypes 61
  • Earliest
    J:38581 Sommer L, et al., neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996;8(4):221-41
  • Latest
    J:235974 Sojoodi M, et al., The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling. Diabetologia. 2016 Jul;59(7):1474-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory