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Neurog3
Gene Detail
Symbol

Name
ID
Neurog3
neurogenin 3
MGI:893591
Synonyms
Atoh5, bHLHa7, Math4B, ngn3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.35 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:62133090-62134763 bp, + strand
From NCBI annotation of GRCm38

  1674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: NEUROG3
Gene Tree: Neurog3

Human
homologs
NEUROG3, neurogenin 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 50674
neXtProt AC: NX_Q9Y4Z2

Human Synonyms: Atoh5, bHLHa7, Math4B, ngn3, NGN-3

Human Chr (Location): 10q21.3; chr10:69572035-69573454 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NEUROG3

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
 
Homozygotes for targeted null mutations are deficient in endocrine cells of the glandular stomach and intestinal epithelium, and lack glucagon- and insulin-producing cells of the pancreas. Mutants die postnatally from diabetes.
 
Interactions
Neurog3 interacts with 109 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell differentiation, epithelial cell differentiation, ...
Component cytoplasm, intracellular, ...
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (224 records)
Data Summary: Results (475)    Tissues (274)    Images (187)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 85
RNA in situ 345
Northern blot 2
RT-PCR 43
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase neurog3 ; ZFIN neurog3    NEW 
Molecular
reagents
All nucleic(29) Genomic(3) cDNA(15) Primer pair(10) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000044312 (Evidence)
Entrez Gene 11925 (Evidence)
DFCI TC1679257, TC1592863
DoTS DT.110630064, DT.55279098
NIA Mouse Gene Index U011576
Consensus CDS Project CCDS23887.1
International Mouse Phenotyping Consortium Status Neurog3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11925 NCBI Gene Model | MGI Sequence Detail 1674 C57BL/6J ±  kb
transcript NM_009719 RefSeq | MGI Sequence Detail 1540 C57BL/6 
polypeptide P70661 UniProt | EBI | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000011158 neurogenin-3
Graphical View of Protein Domain Structure
References
(Earliest) J:38581 Sommer L, et al., neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996;8(4):221-41
(Latest) J:220744 Xu EE, et al., SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
All references(277)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory