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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Neurog3
neurogenin 3
MGI:893591
56 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Neurog3tm1(EGFP)Khk/Neurog3tm1(EGFP)Khk
involves: 129S6/SvEvTac * C57BL/6 		abnormal pancreatic alpha cell morphology J:77398
abnormal pancreatic beta cell morphology J:77398
abnormal pancreatic delta cell morphology J:77398
disorganized stomach mucosa J:77398
increased stomach mucosa thickness J:77398
regional gastric metaplasia J:77398
small stomach J:77398
Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
involves: 129S6/SvEvTac 		impaired glucose tolerance J:150074
Neurog3tm1.1Ggr/Neurog3tm1.1Ggr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		no abnormal phenotype detected J:93570
Neurog3tm1Fgu/Neurog3tm1Fgu
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal pancreatic acinar cell morphology J:60642
absent pancreatic alpha cells J:60642
absent pancreatic beta cells J:60642
absent pancreatic islets J:60642
decreased body weight J:60642
dehydration J:60642
increased circulating glucose level J:60642
increased urine glucose level J:60642
pancreatic acinar cell zymogen granule accumulation J:60642
postnatal lethality, complete penetrance J:60642
Neurog3tm1Fgu/Neurog3tm3.1Ggr
Tg(Vil1-cre)20Syr/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL 		abnormal abdominal fat pad morphology J:161480
abnormal intestinal enteroendocrine cell morphology J:161480
abnormal intestinal goblet cell morphology J:161480
abnormal intestinal lipid absorption J:161480
abnormal intestinal transit time J:161480
abnormal intestine development J:161480
abnormal large intestine morphology J:161480
abnormal pancreatic islet morphology J:161480
abnormal small intestinal crypt cell proliferation J:161480
abnormal small intestinal microvillus morphology J:161480
abnormal small intestinal villus morphology J:161480
abnormal small intestine crypts of Lieberkuhn morphology J:161480
decreased birth weight J:161480
decreased body mass index J:161480
decreased body size J:161480
decreased circulating cholesterol level J:161480
decreased circulating glucose level J:161480
decreased circulating HDL cholesterol level J:161480
decreased circulating serum albumin level J:161480
decreased circulating triglyceride level J:161480
decreased small intestinal microvillus size J:161480
decreased total body fat amount J:161480
diarrhea J:161480
improved glucose tolerance J:161480
increased blood urea nitrogen level J:161480
increased circulating bicarbonate level J:161480
increased defecation amount J:161480
increased insulin sensitivity J:161480
increased lean body mass J:161480
postnatal growth retardation J:161480
postnatal lethality, incomplete penetrance J:161480
small pancreatic islets J:161480
steatorrhea J:161480
Neurog3tm1Heed/Neurog3tm1Heed
Not Specified 		abnormal endocrine pancreas morphology J:147764
Neurog3tm3.1Ggr/Neurog3tm3.1Ggr
involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL 		no abnormal phenotype detected J:161480
Neurog3tm3.1Ggr/Neurog3tm3.1Ggr
Tg(CDX2-cre)101Erf/0
involves: 129S2/SvPas * C57BL/6J * SJL/J 		decreased enteroendocrine cell number J:285572
normal digestive/alimentary phenotype J:285572
Neurog3tm3.1Ggr/Neurog3tm3.1Ggr
Tg(Vil1-cre)20Syr/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL 		abnormal abdominal fat pad morphology J:161480
abnormal intestinal enteroendocrine cell morphology J:161480
abnormal intestinal goblet cell morphology J:161480
abnormal intestinal lipid absorption J:161480
abnormal intestinal transit time J:161480
abnormal intestine development J:161480
abnormal large intestine morphology J:161480
abnormal pancreatic islet morphology J:161480
abnormal small intestinal crypt cell proliferation J:161480
abnormal small intestinal microvillus morphology J:161480
abnormal small intestinal villus morphology J:161480
abnormal small intestine crypts of Lieberkuhn morphology J:161480
decreased birth weight J:161480
decreased body mass index J:161480
decreased body size J:161480
decreased circulating cholesterol level J:161480
decreased circulating glucose level J:161480
decreased circulating HDL cholesterol level J:161480
decreased circulating serum albumin level J:161480
decreased circulating triglyceride level J:161480
decreased small intestinal microvillus size J:161480
decreased total body fat amount J:161480
diarrhea J:161480
improved glucose tolerance J:161480
increased blood urea nitrogen level J:161480
increased circulating bicarbonate level J:161480
increased defecation amount J:161480
increased insulin sensitivity J:161480
increased lean body mass J:161480
postnatal growth retardation J:161480
postnatal lethality, incomplete penetrance J:161480
small pancreatic islets J:161480
steatorrhea J:161480
Tg(Pdx1-Neurog3)1Heed/?
involves: C57BL/6 * CBA 		abnormal pancreas development J:57072
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory