Prap1
Gene Detail

Symbol Name ID

Prap1 proline-rich acidic protein 1 MGI:893573

Synonyms

Upa

Feature Type

protein coding gene

Genetic Map

Chromosome 7

85.10 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:140093395-140097200 bp, + strand From VEGA annotation of GRCm38   3806 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:130637  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

Gene Tree: Prap1

Human homologs

Human Homolog		PRAP1, proline-rich acidic protein 1
NCBI Gene ID		118471
neXtProt AC		NX_Q96NZ9
Human Synonyms		PRO1195, RP11-122K13.6, UPA
Human Chr (Location)		10q26.3; chr10:135160844-135166187 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutant mice exhibited an increased mean serum IgG2a response to ovalbumin challenge when compared with that of controls. The mutants also exhibited increased mean serum immunoglobulin levels.

 

Gene Ontology (GO) classifications

All GO classifications: (1 annotations)

Component

extracellular region

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (52)    Tissues (50)    Images (3)
Theiler Stages: 11, 21, 23, 25, 28

Assay Type	Results
RNA in situ	1
RT-PCR	51

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(41) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027344 (Evidence)
Ensembl Gene Model	ENSMUSG00000025467 (Evidence)
Entrez Gene	22264 (Evidence)
UniGene	439707
DFCI	TC1583825, TC1657946
DoTS	DT.494045
NIA Mouse Gene Index	U008915
Consensus CDS Project	CCDS21963.1
International Mouse Knockout Project Status	Prap1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027344	VEGA Gene Model | MGI Sequence Detail	3806	C57BL/6J
transcript	OTTMUST00000067624	VEGA | MGI Sequence Detail	620	Not Applicable
polypeptide	OTTMUSP00000034050	VEGA | MGI Sequence Detail	149	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000013171	proline-rich acidic protein 1

References

(Earliest) J:53304 Schorpp-Kistner M, et al., JunB is essential for mammalian placentation. EMBO J. 1999 Feb 15;18(4):934-48
(Latest) J:176496 Khalife M, et al., Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis. PLoS One. 2011;6(8):e23253
All references(34)