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Spib
Gene Detail
 Symbol
Name
ID
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
MGI:892986
Synonyms Spi-B
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:44525995-44532071 bp, - strand
From NCBI annotation of GRCm38

  6077 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:79220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: transcription factor Spi-B
Gene Tree: Spib

Human
homologs
Human Homolog SPIB, Spi-B transcription factor (Spi-1/PU.1 related)
NCBI Gene ID 6689
neXtProt AC  NX_Q01892
Human Synonyms  SPI-B
Human Chr (Location)  19q13.3-q13.4; chr19:50418938-50431053 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit severe defects in B cell function and selective T cell-dependent humoral immune responses. Mutant B cells display a defective germinal center reaction upon immunization with DNP-KLH and proliferate poorly in vitro in response to IgM cross-linking.
 
Interactions
Spib interacts with 181 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process macrophage differentiation, regulation of transcription, DNA-templated, ...
Component nucleus, transcription factor complex
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (98)    Tissues (95)   
Theiler Stages: 22, 26
Assay TypeResults
RNA in situ 94
Northern blot 4
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000008193 (Evidence)
Entrez Gene272382 (Evidence)
UniGene8012
DFCITC1632863, TC1651159
DoTSDT.40180783, DT.91339600
NIA Mouse Gene IndexU106279
Consensus CDS ProjectCCDS21209.1
International Mouse Knockout Project StatusSpib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 272382 NCBI Gene Model | MGI Sequence Detail 6077 C57BL/6J ±  kb
transcript NM_019866 RefSeq | MGI Sequence Detail 2786 Not Specified 
polypeptide O35906 UniProt | EBI | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(24) UniProt(2)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015525 transcription factor Spi-B
Graphical View of Protein Domain Structure
References (Earliest) J:2525 Ray D, et al., Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol. 1992 Oct;12(10):4297-304
(Latest) J:192367 Sasaki I, et al., Spi-B is critical for plasmacytoid dendritic cell function and development. Blood. 2012 Dec 6;120(24):4733-43
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory