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Spib Gene Detail
Summary
  • Symbol
    Spib
  • Name
    Spi-B transcription factor (Spi-1/PU.1 related)
  • Synonyms
    Spi-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:892986
    NCBI Gene: 272382
  • Gene Overview
    MyGene.info: SPIB
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44525993-44532071 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892986
protein coding gene Chr7:44525993-44532087 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032167
protein coding gene Chr7:44701022-44707103 (-)
A/J MGP_AJ_G0032146
protein coding gene Chr7:43883170-43889249 (-)
AKR/J MGP_AKRJ_G0032082
protein coding gene Chr7:45088670-45094765 (-)
BALB/cJ MGP_BALBcJ_G0032158
protein coding gene Chr7:43879207-43885281 (-)
C3H/HeJ MGP_C3HHeJ_G0031874
protein coding gene Chr7:45579125-45585211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032650
protein coding gene Chr7:46960401-46966480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029664
protein coding gene Chr7:46468422-46474629 (-)
CAST/EiJ MGP_CASTEiJ_G0031202
protein coding gene Chr7:36958697-36968641 (-)
CBA/J MGP_CBAJ_G0031838
protein coding gene Chr7:48500428-48508090 (-)
DBA/2J MGP_DBA2J_G0031996
protein coding gene Chr7:43557228-43563285 (-)
FVB/NJ MGP_FVBNJ_G0031947
protein coding gene Chr7:43298125-43304201 (-)
LP/J MGP_LPJ_G0032074
protein coding gene Chr7:45387045-45393122 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031984
protein coding gene Chr7:47236789-47242879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032666
protein coding gene Chr7:44308591-44315455 (-)
PWK/PhJ MGP_PWKPhJ_G0030925
protein coding gene Chr7:36905849-36912099 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030762
protein coding gene Chr7:32312468-32318563 (-)
WSB/EiJ MGP_WSBEiJ_G0031319
protein coding gene Chr7:44765725-44771819 (-)



Homology
more
  • Human Ortholog
    SPIB, Spi-B transcription factor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SPIB, Spi-B transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPI-B
  • Links
    NCBI Gene ID: 6689
    neXtProt AC: NX_Q01892
    UniProt: Q01892

  • Chr Location
    19q13.33; chr19:50418938-50431053 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit severe defects in B cell function and selective T cell-dependent humoral immune responses. Mutant B cells display a defective germinal center reaction upon immunization with DNP-KLH and proliferate poorly in vitro in responseto IgM cross-linking.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008193 Ensembl Gene Model | MGI Sequence Detail 6079 C57BL/6J ±  kb
    transcript ENSMUST00000098483 Ensembl | MGI Sequence Detail 853 Not Applicable  
    polypeptide ENSMUSP00000096084 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR000418 Ets domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:2525 Ray D, et al., Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol. 1992 Oct;12(10):4297-304
    • Latest
      J:257471 Kanaya T, et al., Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-kappaB signaling. J Exp Med. 2018 Feb 5;215(2):501-519

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory