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Spib
Gene Detail
Symbol

Name
ID
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
MGI:892986
Synonyms
Spi-B
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:44525995-44532071 bp, - strand
From Ensembl annotation of GRCm38

  6077 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:79220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SPIB
Protein SuperFamily: transcription factor Spi-B
Gene Tree: Spib

Human
homologs
SPIB, Spi-B transcription factor (Spi-1/PU.1 related)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6689
neXtProt AC: NX_Q01892

Human Synonyms: SPI-B

Human Chr (Location): 19q13.3-q13.4; chr19:50418938-50431053 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit severe defects in B cell function and selective T cell-dependent humoral immune responses. Mutant B cells display a defective germinal center reaction upon immunization with DNP-KLH and proliferate poorly in vitro in response to IgM cross-linking.
 
Interactions
Spib interacts with 181 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (98)    Tissues (95)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 4
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase spib    NEW 
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000008193 (Evidence)
Entrez Gene 272382 (Evidence)
UniGene 8012
DFCI TC1651159, TC1632863
DoTS DT.40180783, DT.91339600
NIA Mouse Gene Index U106279
Consensus CDS Project CCDS21209.1
International Mouse Phenotyping Consortium Status Spib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000008193 Ensembl Gene Model | MGI Sequence Detail 6077 C57BL/6J ±  kb
transcript ENSMUST00000098483 Ensembl | MGI Sequence Detail 2840 Not Applicable 
polypeptide ENSMUSP00000096084 Ensembl | MGI Sequence Detail 285 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(16) UniProt(2)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015525 transcription factor Spi-B
References
(Earliest) J:2525 Ray D, et al., Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol. 1992 Oct;12(10):4297-304
(Latest) J:220775 Sasaki H, et al., Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood. 2015 Jan 8;125(2):358-69
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory