Spib Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spib
Spi-B transcription factor (Spi-1/PU.1 related)
MGI:892986

15 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spib^tm1Ksho/Spib^tm1Ksho involves: C57BL/6J	abnormal intestine morphology	J:187649
	abnormal Peyer's patch morphology	J:187649
	normal digestive/alimentary phenotype	J:187649
	increased susceptibility to bacterial infection	J:187649
Spib^tm1Mcs/Spib^tm1Mcs involves: 129S1/Sv * 129X1/SvJ	abnormal humoral immune response	J:45245
	abnormal spleen B cell follicle morphology	J:45245
	abnormal spleen germinal center morphology	J:45245
	abnormal spleen white pulp morphology	J:45245
	decreased B cell proliferation	J:45245
	decreased IgG1 level	J:45245
	decreased IgG2a level	J:45245
	decreased IgG2b level	J:45245
	increased B cell apoptosis	J:45245
	increased IgM level	J:45245
Spib^tm1Mcs/Spib^tm1Mcs involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal immature B cell morphology	J:88257
	decreased B cell proliferation	J:88257

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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