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Tacr3 Gene Detail
Summary
  • Symbol
    Tacr3
  • Name
    tachykinin receptor 3
  • Synonyms
    neuromedin K receptor, Nk3r, Tac3r
  • Feature Type
    protein coding gene
  • IDs
    MGI:892968
    NCBI Gene: 21338
Location & Maps
more
  • Sequence Map
    Chr3:134829007-134934579 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      105573 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TACR3, tachykinin receptor 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TACR3, tachykinin receptor 3
    Orthology source: HomoloGene
  • Synonyms
    HH11, NK3R, NK-3R, NKR, TAC3RL
  • Links
    NCBI Gene ID: 6870
    neXtProt AC: NX_P29371

  • Chr Location
    4q25; chr4:103589468-103719816 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TACR3 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 11 with or without Anosmia; HH11   OMIM: 614840
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tacr3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased body weight and cognitive deficits in tests associated with learning and memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049886 VEGA Gene Model | MGI Sequence Detail 105573 C57BL/6J ±  kb
transcript OTTMUST00000127020 VEGA | MGI Sequence Detail 3762 Not Applicable  
polypeptide OTTMUSP00000068641 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    605 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 13
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
  • Latest
    J:222626 McClelland KS, et al., Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory