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Tacr3 Gene Detail
Summary
  • Symbol
    Tacr3
  • Name
    tachykinin receptor 3
  • Synonyms
    neuromedin K receptor, Nk3r, Tac3r
  • Feature Type
    protein coding gene
  • IDs
    MGI:892968
    NCBI Gene: 21338
  • Gene Overview
    MyGene.info: TACR3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:134829007-134934579 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 62.47 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    603 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892968
protein coding gene Chr3:134829007-134934581 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027901
protein coding gene Chr3:137688149-137791455 (+)
A/J MGP_AJ_G0027859
protein coding gene Chr3:132857471-132955480 (+)
AKR/J MGP_AKRJ_G0027824
protein coding gene Chr3:136368477-136468883 (+)
BALB/cJ MGP_BALBcJ_G0027872
protein coding gene Chr3:132702982-132808073 (+)
C3H/HeJ MGP_C3HHeJ_G0027601
protein coding gene Chr3:136714966-136825143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028315
protein coding gene Chr3:142512784-142621019 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025653
protein coding gene Chr3:128128381-128223530 (+)
CAST/EiJ MGP_CASTEiJ_G0027057
protein coding gene Chr3:136428301-136535652 (+)
CBA/J MGP_CBAJ_G0027577
protein coding gene Chr3:147342870-147458593 (+)
DBA/2J MGP_DBA2J_G0027717
protein coding gene Chr3:132007652-132110257 (+)
FVB/NJ MGP_FVBNJ_G0027684
protein coding gene Chr3:129527546-129619801 (+)
LP/J MGP_LPJ_G0027827
protein coding gene Chr3:139137827-139235443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027715
protein coding gene Chr3:155453704-155559740 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028373
protein coding gene Chr3:135893416-136007036 (+)
PWK/PhJ MGP_PWKPhJ_G0026781
protein coding gene Chr3:131744894-131845670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026607
protein coding gene Chr3:134010267-134104099 (+)
WSB/EiJ MGP_WSBEiJ_G0027136
protein coding gene Chr3:136706064-136813428 (+)



Homology
more
  • Human Ortholog
    TACR3, tachykinin receptor 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TACR3, tachykinin receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH11, NK3, NK3R, NK-3R, NKR, TAC3R, TAC3RL
  • Links
    NCBI Gene ID: 6870
    neXtProt AC: NX_P29371
    UniProt: P29371

  • Chr Location
    4q24; chr4:103589468-103719816 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tacr3 mouse models; 1 with human TACR3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased body weight, cognitive deficits in tests associated with learning and memory and symptoms of hypogonadotropic hypogonadism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028172 Ensembl Gene Model | MGI Sequence Detail 105573 C57BL/6J ±  kb
    transcript ENSMUST00000029822 Ensembl | MGI Sequence Detail 3762 Not Applicable  
    polypeptide ENSMUSP00000029822 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
    • Latest
      J:245600 Xie Y, et al., Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biol. 2017 Aug;15(8):e2002257

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory