About   Help   FAQ
Tacr3
Gene Detail
Symbol

Name
ID
Tacr3
tachykinin receptor 3
MGI:892968
Synonyms
neuromedin K receptor, Nk3r, Tac3r
Feature Type
protein coding gene
Genetic Map
Chromosome 3
62.47 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:134829007-134934579 bp, + strand
From VEGA annotation of GRCm38

  105573 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TACR3
Protein SuperFamily: tachykinin receptor
Gene Tree: Tacr3

Human
homologs
TACR3, tachykinin receptor 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6870
neXtProt AC: NX_P29371

Human Synonyms: HH11, NK3R, NK-3R, NKR, TAC3RL

Human Chr (Location): 4q25; chr4:103589468-103719816 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TACR3

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased body weight and cognitive deficits in tests associated with learning and memory.
 
Interactions
Tacr3 interacts with 304 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (224)    Tissues (154)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 132
RT-PCR 92
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tacr3 ; ZFIN tacr3a, tacr3l    NEW 
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049886 (Evidence)
Ensembl Gene Model ENSMUSG00000028172 (Evidence)
Entrez Gene 21338 (Evidence)
UniGene 103810
DFCI TC1757385, TC1599250, TC1584679
DoTS DT.91430770, DT.55165449
NIA Mouse Gene Index U003877
Consensus CDS Project CCDS17852.1
International Mouse Phenotyping Consortium Status Tacr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049886 VEGA Gene Model | MGI Sequence Detail 105573 C57BL/6J ±  kb
transcript OTTMUST00000127020 VEGA | MGI Sequence Detail 3762 Not Applicable 
polypeptide OTTMUSP00000068641 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(605 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001013 Neurokinin NK3 receptor
InterPro IPR001681 Neurokinin receptor
Protein Ontology PR:000001242 neuromedin-K receptor
References
(Earliest) J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
(Latest) J:219786 Naillat F, et al., Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. Exp Cell Res. 2015 Mar 15;332(2):163-78
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory