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Tacr3
Gene Detail
Symbol

Name
ID
Tacr3
tachykinin receptor 3
MGI:892968
Synonyms
neuromedin K receptor, Nk3r, Tac3r
Feature Type
protein coding gene
Genetic Map
Chromosome 3
62.47 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:134829007-134934581 bp, + strand
From NCBI annotation of GRCm38

  105575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: tachykinin receptor
Gene Tree: Tacr3

Human
homologs
Human Homolog TACR3, tachykinin receptor 3
NCBI Gene ID 6870
neXtProt AC  NX_P29371
Human Synonyms  HH11, NK3R, NK-3R, NKR, TAC3RL
Human Chr (Location)  4q25; chr4:103589468-103719816 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TACR3
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased body weight and cognitive deficits in tests associated with learning and memory.
 
Interactions
Tacr3 interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (224)    Tissues (154)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 132
RT-PCR 92
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028172 (Evidence)
Entrez Gene21338 (Evidence)
UniGene103810
DFCITC1599250, TC1584679, TC1757385
DoTSDT.55165449, DT.91430770
NIA Mouse Gene IndexU003877
Consensus CDS ProjectCCDS17852.1
International Mouse Knockout Project StatusTacr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21338 NCBI Gene Model | MGI Sequence Detail 105575 C57BL/6J ±  kb
transcript NM_021382 RefSeq | MGI Sequence Detail 3764 C57BL/6 
polypeptide P47937 UniProt | EBI | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(605 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001013 Neurokinin NK3 receptor
InterPro IPR001681 Neurokinin receptor
Protein Ontology PR:000001242 neuromedin-K receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
(Latest) J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory