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Tacr3tm1Jasi
Targeted Allele Detail
Summary
Symbol: Tacr3tm1Jasi
Name: tachykinin receptor 3; targeted mutation 1, Judith A Siuciak
MGI ID: MGI:3841488
Synonyms: NK3-, NK3R-
Gene: Tacr3  Location: Chr3:134534768-134640340 bp, + strand  Genetic Position: Chr3, 62.47 cM, cytoband H2
Alliance: Tacr3tm1Jasi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147538
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ reporter and neomycin resistance cassette replaced exon 1. Gene inactivation was confirmed by a lack mRNA in homozygote cerebral cortex as determined by RT-PCR. (J:147538)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacr3 Mutation:  23 strains or lines available
References
Original:  J:147538 Siuciak JA, et al., Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits. Psychopharmacology (Berl). 2007 Oct;194(2):185-95
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/21/2023
MGI 6.22
The Jackson Laboratory