About   Help   FAQ
Sfrp4 Gene Detail
Summary
  • Symbol
    Sfrp4
  • Name
    secreted frizzled-related protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:892010
    NCBI Gene: 20379
  • Gene Overview
    MyGene.info: SFRP4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:19623175-19632825 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892010
protein coding gene Chr13:19623104-19632994 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020260
protein coding gene Chr13:16799607-16809220 (+)
A/J MGP_AJ_G0020217
protein coding gene Chr13:16530057-16539681 (+)
AKR/J MGP_AKRJ_G0020191
protein coding gene Chr13:16728484-16738130 (+)
BALB/cJ MGP_BALBcJ_G0020203
protein coding gene Chr13:16558738-16568362 (+)
C3H/HeJ MGP_C3HHeJ_G0020006
protein coding gene Chr13:16860136-16869756 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020647
protein coding gene Chr13:17453414-17463061 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018254
protein coding gene Chr13:14961259-14971161 (+)
CAST/EiJ MGP_CASTEiJ_G0019541
protein coding gene Chr13:16593273-16607380 (+)
CBA/J MGP_CBAJ_G0019970
protein coding gene Chr13:18051979-18064388 (+)
DBA/2J MGP_DBA2J_G0020089
protein coding gene Chr13:16123893-16133523 (+)
FVB/NJ MGP_FVBNJ_G0020071
protein coding gene Chr13:15806688-15816306 (+)
LP/J MGP_LPJ_G0020160
protein coding gene Chr13:17044676-17054554 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020109
protein coding gene Chr13:18481565-18493812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020676
protein coding gene Chr13:16548140-16557786 (+)
PWK/PhJ MGP_PWKPhJ_G0019304
protein coding gene Chr13:16178265-16192599 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019110
protein coding gene Chr13:15624869-15636968 (+)
WSB/EiJ MGP_WSBEiJ_G0019600
protein coding gene Chr13:16608882-16618492 (+)



Homology
more
  • Human Ortholog
    SFRP4, secreted frizzled related protein 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SFRP4, secreted frizzled related protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRP-4, FRPHE, FRZB-2, PYL, sFRP-4
  • Links
    NCBI Gene ID: 6424
    neXtProt AC: NX_Q6FHJ7
    UniProt: Q6FHJ7

  • Chr Location
    7p14.1; chr7:37905932-37916923 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2267
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SFRP4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit a slight reduction in female fertility, normal body size, and normal serum phosphate and calcium levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20379 NCBI Gene Model | MGI Sequence Detail 9651 C57BL/6J ±  kb
    transcript NM_016687 RefSeq | MGI Sequence Detail 1780 C57BL/6  
    polypeptide Q9Z1N6 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 23
      Primer pair 5
      Other 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 23
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:256184 Haraguchi R, et al., sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep. 2016 Apr 27;6:25198

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory