Sfrp4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sfrp4
secreted frizzled-related protein 4
MGI:892010

26 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sfrp4^tm1.1Blan/Sfrp4⁺ Not Specified	abnormal bone mineralization	J:234467
	decreased compact bone thickness	J:234467
	increased trabecular bone volume	J:234467
Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan involves: C57BL/6	decreased litter size	J:173962
	normal growth/size/body region phenotype	J:173962
	normal homeostasis/metabolism phenotype	J:173962
	reduced female fertility	J:173962
Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Not Specified	abnormal bone mineralization	J:234467
	abnormal bone ossification	J:234467
	abnormal bone remodeling	J:234467
	abnormal long bone metaphysis morphology	J:234467
	decreased bone strength	J:234467
	decreased compact bone thickness	J:234467
	decreased femur compact bone thickness	J:234467
	increased bone ossification	J:234467
	increased bone resorption	J:234467
	increased diameter of long bones	J:234467
	increased osteoclast cell number	J:234467
	increased trabecular bone volume	J:234467
Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	abnormal ovarian folliculogenesis	J:275639
	increased litter size	J:275639
	increased mature ovarian follicle number	J:275639
	normal reproductive system phenotype	J:275639
Sfrp4^tm1.1Lex/Sfrp4⁺ Not Specified	abnormal bone mineralization	J:234467
	decreased compact bone thickness	J:234467
	increased trabecular bone volume	J:234467
Sfrp4^tm1.1Lex/Sfrp4^tm1.1Lex Not Specified	abnormal bone mineralization	J:234467
	abnormal bone ossification	J:234467
	abnormal bone remodeling	J:234467
	abnormal long bone metaphysis morphology	J:234467
	decreased bone strength	J:234467
	decreased compact bone thickness	J:234467
	decreased femur compact bone thickness	J:234467
	increased bone ossification	J:234467
	increased bone resorption	J:234467
	increased diameter of long bones	J:234467
	increased osteoclast cell number	J:234467
	increased trabecular bone volume	J:234467
Sfrp4^tm1Maki/Sfrp4^tm1Maki Not Specified	decreased bone trabecular spacing	J:256184
	decreased compact bone mass	J:256184
	decreased compact bone thickness	J:256184
	decreased susceptibility to osteoporosis	J:256184
	increased bone trabecula number	J:256184
	increased trabecular bone connectivity density	J:256184
	increased trabecular bone mass	J:256184

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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