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Xrn1 Gene Detail
Summary
  • Symbol
    Xrn1
  • Name
    5'-3' exoribonuclease 1
  • Synonyms
    Dhm2, mXrn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891964
    NCBI Gene: 24127
Location & Maps
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  • Sequence Map
    Chr9:95954767-96057803 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      103037 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    XRN1, 5'-3' exoribonuclease 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    XRN1, 5'-3' exoribonuclease 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SEP1
  • Links
    NCBI Gene ID: 54464
    neXtProt AC: NX_Q8IZH2

  • Chr Location
    3q23; chr3:142306607-142448062 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Genomic Mutations
    1 involving Xrn1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047300 VEGA Gene Model | MGI Sequence Detail 103037 C57BL/6J ±  kb
transcript OTTMUST00000122294 VEGA | MGI Sequence Detail 10256 Not Applicable  
polypeptide OTTMUSP00000067137 VEGA | MGI Sequence Detail 1719 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    873 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:39219 Bashkirov VI, et al., A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J Cell Biol. 1997 Feb 24;136(4):761-73
  • Latest
    J:213939 Shukla S, et al., Quality control of assembly-defective U1 snRNAs by decapping and 5'-to-3' exonucleolytic digestion. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3277-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory