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Cyr61
Gene Detail
 Symbol
Name
ID
Cyr61
cysteine rich protein 61
MGI:88613
STS D3Mit113
Synonyms CCN1
Feature Type protein coding gene
Genetic Map
Chromosome 3
70.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:145646971-145649985 bp, - strand
From NCBI annotation of GRCm38

  3015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: IGFBP-related protein, CNN type
Gene Tree: Cyr61

Human
homologs
Human Homolog CYR61, cysteine-rich, angiogenic inducer, 61
NCBI Gene ID 3491
neXtProt AC  NX_O00622
Human Synonyms  CCN1, GIG1, IGFBP10
Human Chr (Location)  1p22.3; chr1:85580761-85583967 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted null mice die pre- or perinatally, and none survive beyond 24 hrs of birth. About 30% of embryos die by E10.5 from defects in chorioallantoic fusion, whereas 70% die from placental vascular defects, including impaired allantoic vessel bifurcation, and loss of large-vessel integrity.
 
Human Diseases Modeled Using Mouse Cyr61 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process apoptotic process involved in heart morphogenesis, atrial septum morphogenesis, ...
Component extracellular region
Function extracellular matrix binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (106)    Tissues (102)    Images (24)
Theiler Stages: 11, 21, 22
Assay TypeResults
Immunohistochemistry 10
RNA in situ 95
RT-PCR 1
cDNA source data(110)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(114) Genomic(2) cDNA(110) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000028195 (Evidence)
Entrez Gene16007 (Evidence)
UniGene1231
DFCITC1572761
DoTSDT.532902, DT.55245111
NIA Mouse Gene IndexU024738
Consensus CDS ProjectCCDS17895.1
International Mouse Knockout Project StatusCyr61
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16007 NCBI Gene Model | MGI Sequence Detail 3015 C57BL/6J ±  kb
transcript NM_010516 RefSeq | MGI Sequence Detail 2028 C57BL/6 
polypeptide P18406 UniProt | EBI | MGI Sequence Detail 379 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR012395 IGFBP-related, CNN
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000006151 protein CYR61
Graphical View of Protein Domain Structure
References (Earliest) J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
(Latest) J:210276 Hsu PL, et al., Extracellular matrix protein CCN1 regulates cardiomyocyte apoptosis in mice with stress-induced cardiac injury. Cardiovasc Res. 2013 Apr 1;98(1):64-72
All references(57)
Other
accession IDs
MGD-MRK-2336, MGI:2139677

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory