Cyr61
Gene Detail

Symbol Name ID

Cyr61 cysteine rich protein 61 MGI:88613

STS

D3Mit113

Synonyms

CCN1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

70.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:145646971-145649985 bp, - strand From NCBI annotation of GRCm38   3015 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: IGFBP-related protein, CNN type
Gene Tree: Cyr61

Human homologs

Human Homolog		CYR61, cysteine-rich, angiogenic inducer, 61
NCBI Gene ID		3491
neXtProt AC		NX_O00622
Human Synonyms		CCN1, GIG1, IGFBP10
Human Chr (Location)		1p22.3; chr1:86046444-86049650 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Targeted null mice die pre- or perinatally, and none survive beyond 24 hrs of birth. About 30% of embryos die by E10.5 from defects in chorioallantoic fusion, whereas 70% die from placental vascular defects, including impaired allantoic vessel bifurcation, and loss of large-vessel integrity.

 
Human Diseases Modeled Using Mouse Cyr61 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	apoptotic process involved in heart morphogenesis, atrial septum morphogenesis, ...
Component	extracellular region
Function	extracellular matrix binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (106)    Tissues (102)    Images (24)
Theiler Stages: 11, 21, 22

Assay Type	Results
Immunohistochemistry	10
RNA in situ	95
RT-PCR	1

cDNA source data(107)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(111) Genomic(2) cDNA(107) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000028195 (Evidence)
Entrez Gene	16007 (Evidence)
UniGene	1231
DFCI	TC1572761
DoTS	DT.532902, DT.55245111
NIA Mouse Gene Index	U024738
Consensus CDS Project	CCDS17895.1
International Mouse Knockout Project Status	Cyr61

Sequences

Length	Strain/Species
genomic	16007	NCBI Gene Model | MGI Sequence Detail	3015	C57BL/6J
transcript	NM_010516	RefSeq | MGI Sequence Detail	2028	C57BL/6
polypeptide	P18406	UniProt | EBI | MGI Sequence Detail	379	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006208	Cystine knot
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR012395	IGFBP-related, CNN
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000884	Thrombospondin, type 1 repeat
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000006151	protein CYR61

Graphical View of Protein Domain Structure

References

(Earliest) J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
(Latest) J:188729 Lin J, et al., Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis. J Immunol. 2012 Jun 1;188(11):5776-84
All references(52)

Other accession IDs

MGD-MRK-2336, MGI:2139677