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Cyr61 Gene Detail
Summary
  • Symbol
    Cyr61
  • Name
    cysteine rich protein 61
  • Synonyms
    CCN1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88613
    NCBI Gene: 16007
Location & Maps
more
  • Sequence Map
    Chr3:145646976-145649981 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3006 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CYR61, cysteine rich angiogenic inducer 61
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYR61, cysteine rich angiogenic inducer 61
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCN1, GIG1, IGFBP10
  • Links
    NCBI Gene ID: 3491
    neXtProt AC: NX_O00622

  • Chr Location
    1p22.3; chr1:85580761-85583967 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Cyr61 mouse models

Human Disease Mouse Models
       Atrial Septal Defect 1; ASD1   OMIM: 108800 View 1 model
Atrioventricular Septal Defect; AVSD   OMIM: 606215 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cyr61
  • Incidental Mutations
Targeted null mice die pre- or perinatally, and none survive beyond 24 hrs of birth. About 30% of embryos die by E10.5 from defects in chorioallantoic fusion, whereas 70% die from placental vascular defects, including impaired allantoic vessel bifurcation, and loss of large-vessel integrity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055191 VEGA Gene Model | MGI Sequence Detail 3006 C57BL/6J ±  kb
transcript OTTMUST00000136695 VEGA | MGI Sequence Detail 2019 Not Applicable  
polypeptide OTTMUSP00000072117 VEGA | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006151 protein CYR61
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR012395 IGFBP-related, CNN
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR001007 VWFC domain
Molecular
Reagents
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  • All nucleic 115
    Genomic 2
    cDNA 111
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-2336, MGI:2139677
References
more
  • Summaries
    All 64
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 13
    Phenotypes 11
  • Earliest
    J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
  • Latest
    J:224948 Lin C, et al., A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory