Cyp2d9
Gene Detail

Symbol Name ID

Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 MGI:88606

Synonyms

Cyp2d, P450-2D, testosterone 16alpha-hydroxylase

Feature Type

protein coding gene

Genetic Map

Chromosome 15

38.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:82452377-82456827 bp, + strand From NCBI annotation of GRCm38   4451 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86099  Vertebrate Homology Class
1 human; 5 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2d9

Human homologs

Human Homolog		CYP2D6, cytochrome P450, family 2, subfamily D, polypeptide 6
NCBI Gene ID		1565
neXtProt AC		NX_P10635
Human Synonyms		CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450C2D, P450DB1, P450-DB1
Human Chr (Location)		22q13.1; chr22:42522501-42526883 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CYP2D6

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	oxidation-reduction process
Component	endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function	aromatase activity, drug binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (128)    Tissues (107)    Images (24)
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	116
RT-PCR	12

cDNA source data(307)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(311) Genomic(3) cDNA(307) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000068086 (Evidence)
Entrez Gene	13105 (Evidence)
UniGene	226708
DoTS	DT.101132950, DT.102537080, DT.87052392, DT.94219384
NIA Mouse Gene Index	U138945
EC	1.14.14.1
Consensus CDS Project	CCDS27691.1
International Mouse Knockout Project Status	Cyp2d9

Sequences

Length	Strain/Species
genomic	13105	NCBI Gene Model | MGI Sequence Detail	4451	C57BL/6J
transcript	NM_010006	RefSeq | MGI Sequence Detail	1651	C57BL/6
polypeptide	P11714	UniProt | EBI | MGI Sequence Detail	504	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
InterPro	IPR008069	Cytochrome P450, E-class, group I, CYP2D-like
Protein Ontology	PR:000006237	cytochrome P450 2D9

Graphical View of Protein Domain Structure

References

(Earliest) J:7796 Harada N, et al., Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2024-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)

Other accession IDs

MGD-MRK-13111, MGD-MRK-2325