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Cyp1b1
Gene Detail
Symbol

Name
ID
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
MGI:88590
Feature Type
protein coding gene
Genetic Map
Chromosome 17
50.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:79706953-79715041 bp, - strand
From Ensembl annotation of GRCm38

  8089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1b1

Human
homologs
Human Homolog CYP1B1, cytochrome P450, family 1, subfamily B, polypeptide 1
NCBI Gene ID 1545
neXtProt AC  NX_Q16678
Human Synonyms  CP1B, CYPIB1, GLC3A, P4501B1
Human Chr (Location)  2p22.2; chr2:38067603-38076181 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CYP1B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are protected from the acute bone marrow cytotoxic and preleukemic effects of DMBA, show a decreased incidence of DMBA-induced lymphomas, and display background-sensitive ocular abnormalities.
 
Human Diseases Modeled Using Mouse Cyp1b1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cyp1b1 interacts with 378 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process angiogenesis, arachidonic acid metabolic process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function aromatase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (154)    Tissues (140)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
RT-PCR 26
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(16) Primer pair(5)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024087 (Evidence)
Entrez Gene13078 (Evidence)
EC1.14.14.1
Consensus CDS ProjectCCDS28986.1
International Mouse Knockout Project StatusCyp1b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024087 Ensembl Gene Model | MGI Sequence Detail 8089 C57BL/6J ±  kb
transcript ENSMUST00000024894 Ensembl | MGI Sequence Detail 5128 Not Applicable 
polypeptide ENSMUSP00000024894 Ensembl | MGI Sequence Detail 543 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(9) UniProt(9)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006103 cytochrome P450 1B1
References
(Earliest) J:27812 Pottenger LH, et al., Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys. 1991 May 1;286(2):488-97
(Latest) J:212446 Bansal S, et al., Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. J Biol Chem. 2014 Apr 4;289(14):9936-51
All references(85)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory