Cyp1b1
Gene Detail

Symbol Name ID

Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 MGI:88590

Feature Type

protein coding gene

Genetic Map

Chromosome 17

50.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:79706953-79715041 bp, - strand From NCBI annotation of GRCm38   8089 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1b1

Human homologs

Human Homolog		CYP1B1, cytochrome P450, family 1, subfamily B, polypeptide 1
NCBI Gene ID		1545
neXtProt AC		NX_Q16678
Human Synonyms		CP1B, CYPIB1, GLC3A, P4501B1
Human Chr (Location)		2p22.2; chr2:38294746-38303323 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CYP1B1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele are protected from the acute bone marrow cytotoxic and preleukemic effects of DMBA, show a decreased incidence of DMBA-induced lymphomas, and display background-sensitive ocular abnormalities.

 
Human Diseases Modeled Using Mouse Cyp1b1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	angiogenesis, cellular aromatic compound metabolic process, ...
Component	endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function	aromatase activity, electron carrier activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (154)    Tissues (140)    Images (8)
Theiler Stages: 10, 18, 19, 22, 23, 25, 28

Assay Type	Results
RNA in situ	128
RT-PCR	26

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(16) Primer pair(5)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024087 (Evidence)
Entrez Gene	13078 (Evidence)
EC	1.14.14.1
Consensus CDS Project	CCDS28986.1
International Mouse Knockout Project Status	Cyp1b1

Sequences

Length	Strain/Species
genomic	13078	NCBI Gene Model | MGI Sequence Detail	8089	C57BL/6J
transcript	NM_009994	RefSeq | MGI Sequence Detail	5128	C3H
polypeptide	Q64429	UniProt | EBI | MGI Sequence Detail	543	Not Applicable

All sequences(23) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
Protein Ontology	PR:000006103	cytochrome P450 1B1

Graphical View of Protein Domain Structure

References

(Earliest) J:27812 Pottenger LH, et al., Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys. 1991 May 1;286(2):488-97
(Latest) J:193505 Galvez-Peralta M, et al., Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. Int J Cancer. 2013 May 1;132(9):2065-75
All references(71)

Other accession IDs

MGD-MRK-2304