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Cyp1b1 Gene Detail
Summary
  • Symbol
    Cyp1b1
  • Name
    cytochrome P450, family 1, subfamily b, polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88590
    NCBI Gene: 13078
  • Gene Overview
    MyGene.info: CYP1B1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:79706953-79715041 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8089 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 50.30 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CYP1B1, cytochrome P450 family 1 subfamily B member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYP1B1, cytochrome P450 family 1 subfamily B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASGD6, CP1B, CYPIB1, GLC3A, P4501B1
  • Links
    NCBI Gene ID: 1545
    neXtProt AC: NX_Q16678
    UniProt: Q16678

  • Chr Location
    2p22.2; chr2:38067603-38076181 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cyp1b1 mouse models; 2 with human CYP1B1 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are protected from the acute bone marrow cytotoxic and preleukemic effects of DMBA, show a decreased incidence of DMBA-induced lymphomas, and display background-sensitive ocular abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024087 Ensembl Gene Model | MGI Sequence Detail 8089 C57BL/6J ±  kb
    transcript ENSMUST00000024894 Ensembl | MGI Sequence Detail 5128 Not Applicable  
    polypeptide ENSMUSP00000024894 Ensembl | MGI Sequence Detail 543 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      145 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2304
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 21
      Phenotypes 32
    • Earliest
      J:27812 Pottenger LH, et al., Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys. 1991 May 1;286(2):488-97
    • Latest
      J:255280 Maguire M, et al., Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development. Mol Cell Endocrinol. 2017 Oct 15;454:50-68

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory