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Cyp1b1
Gene Detail
 Symbol
Name
ID
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
MGI:88590
Feature Type protein coding gene
Genetic Map
Chromosome 17
50.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:79706953-79715041 bp, - strand
From NCBI annotation of GRCm38

  8089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1b1

Human
homologs
Human Homolog CYP1B1, cytochrome P450, family 1, subfamily B, polypeptide 1
NCBI Gene ID 1545
neXtProt AC  NX_Q16678
Human Synonyms  CP1B, CYPIB1, GLC3A, P4501B1
Human Chr (Location)  2p22.2; chr2:38067603-38076181 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYP1B1
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele are protected from the acute bone marrow cytotoxic and preleukemic effects of DMBA, show a decreased incidence of DMBA-induced lymphomas, and display background-sensitive ocular abnormalities.
 
Human Diseases Modeled Using Mouse Cyp1b1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process angiogenesis, benzene-containing compound metabolic process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function aromatase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (154)    Tissues (140)    Images (8)
Theiler Stages: 10, 18, 19, 22, 23, 25, 28
Assay TypeResults
RNA in situ 128
RT-PCR 26
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(16) Primer pair(5)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024087 (Evidence)
Entrez Gene13078 (Evidence)
EC1.14.14.1
Consensus CDS ProjectCCDS28986.1
International Mouse Knockout Project StatusCyp1b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13078 NCBI Gene Model | MGI Sequence Detail 8089 C57BL/6J ±  kb
transcript NM_009994 RefSeq | MGI Sequence Detail 5128 C3H 
polypeptide Q64429 UniProt | EBI | MGI Sequence Detail 543 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(9) UniProt(5)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006103 cytochrome P450 1B1
Graphical View of Protein Domain Structure
References (Earliest) J:27812 Pottenger LH, et al., Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys. 1991 May 1;286(2):488-97
(Latest) J:205875 Divanovic S, et al., Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways. J Immunol. 2013 Sep 15;191(6):3347-57
All references(79)
Other
accession IDs
MGD-MRK-2304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory