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Cyp11b2
Gene Detail
Symbol

Name
ID
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
MGI:88584
Synonyms
aldosterone synthase, Cyp11b, Cyp11b-2, steroid-11-beta-hydroxylase
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74851010-74856318 bp, - strand
From VEGA annotation of GRCm38

  5309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP11B1
Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11b2

Human
homologs
CYP11B1, cytochrome P450, family 11, subfamily B, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1584
neXtProt AC: NX_P15538

Human Synonyms: CPN1, CYP11B, FHI, P450C11

Human Chr (Location): 8q21; chr8:142872354-142879846 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CYP11B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(1) Targeted(5)
Genomic Mutations involving Cyp11b2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some postnatal lethality, altered blood chemistry, hypotension, and abnormal adrenal cortex morphology.
 
Phenotype Images(2)
Interactions
Cyp11b2 interacts with 10 markers (Mir125a, Mir125b-1, Mir125b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process aldosterone biosynthetic process, C21-steroid hormone biosynthetic process, ...
Component dendrite, membrane, ...
Function corticosterone 18-monooxygenase activity, heme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (102)    Tissues (98)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
cDNA source data(3)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(4) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000035251 (Evidence)
Ensembl Gene Model ENSMUSG00000022589 (Evidence)
Entrez Gene 13072 (Evidence)
UniGene 377079
DoTS DT.101298547
EC 1.14.15.4, 1.14.15.5
Consensus CDS Project CCDS27536.2
International Mouse Phenotyping Consortium Status Cyp11b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035251 VEGA Gene Model | MGI Sequence Detail 5309 C57BL/6J ±  kb
transcript OTTMUST00000089902 VEGA | MGI Sequence Detail 1625 Not Applicable 
polypeptide OTTMUSP00000049180 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)    SNPs within 2kb including multiple locations(99)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002399 Cytochrome P450, mitochondrial
Protein Ontology PR:000006098 cytochrome P450 11B2, mitochondrial
References
(Earliest) J:9530 Mouw AR, et al., Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase. J Biol Chem. 1989 Jan 15;264(2):1305-9
(Latest) J:206147 Kurt B, et al., Control of renin secretion from kidneys with renin cell hyperplasia. Am J Physiol Renal Physiol. 2014 Feb;306(3):F327-32
All references(57)
Other
accession IDs
MGD-MRK-2292, MGD-MRK-2294, MGD-MRK-2296

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory