Cyp11b2
Gene Detail

Symbol Name ID

Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 MGI:88584

Synonyms

aldosterone synthase, Cyp11b, Cyp11b-2, steroid-11-beta-hydroxylase

Feature Type

protein coding gene

Genetic Map

Chromosome 15

34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:74851010-74856318 bp, - strand From VEGA annotation of GRCm38   5309 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11b2

Human homologs

Human Homolog		CYP11B1, cytochrome P450, family 11, subfamily B, polypeptide 1
NCBI Gene ID		1584
neXtProt AC		NX_P15538
Human Synonyms		CPN1, CYP11B, FHI, P450C11
Human Chr (Location)		8q21; chr8:143953773-143961236 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CYP11B1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele exhibit some postnatal lethality, altered blood chemistry, hypotension, and abnormal adrenal cortex morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	aldosterone biosynthetic process, C21-steroid hormone biosynthetic process, ...
Component	dendrite, membrane, ...
Function	corticosterone 18-monooxygenase activity, electron carrier activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (102)    Tissues (98)    Images (1)
Theiler Stages: 22, 23, 24, 25, 26

Assay Type	Results
RNA in situ	102

cDNA source data(3)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(2) cDNA(4) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000035251 (Evidence)
Ensembl Gene Model	ENSMUSG00000022589 (Evidence)
Entrez Gene	13072 (Evidence)
UniGene	377079
DoTS	DT.101298547
EC	1.14.15.4, 1.14.15.5
Consensus CDS Project	CCDS27536.2
International Mouse Knockout Project Status	Cyp11b2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035251	VEGA Gene Model | MGI Sequence Detail	5309	C57BL/6J
transcript	OTTMUST00000089902	VEGA | MGI Sequence Detail	1625	Not Applicable
polypeptide	OTTMUSP00000049180	VEGA | MGI Sequence Detail	502	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002399	Cytochrome P450, mitochondrial
Protein Ontology	PR:000006098	cytochrome P450 11B2, mitochondrial

References

(Earliest) J:9530 Mouw AR, et al., Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase. J Biol Chem. 1989 Jan 15;264(2):1305-9
(Latest) J:193254 Machura K, et al., The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion. Am J Physiol Renal Physiol. 2013 Mar;304(5):F578-84
All references(53)

Other accession IDs

MGD-MRK-2292, MGD-MRK-2294, MGD-MRK-2296