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Cyp11b2 Gene Detail
Summary
  • Symbol
    Cyp11b2
  • Name
    cytochrome P450, family 11, subfamily b, polypeptide 2
  • Synonyms
    aldosterone synthase, Cyp11b, Cyp11b-2, steroid-11-beta-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88584
    NCBI Gene: 13072
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74722467-74728080 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88584
 protein coding gene Chr15:74722467-74728167 (-)
129S1/SvImJ ENSMUSG00200053310
 protein coding gene Chr15:71828051-71833385 (-)
A/J ENSMUSG00195045434
 protein coding gene Chr15:71896652-71901966 (-)
AKR/J ENSMUSG00220045396
 protein coding gene Chr15:71817234-71822542 (-)
BALB/cJ ENSMUSG00180045850
 protein coding gene Chr15:71669102-71674416 (-)
C3H/HeJ ENSMUSG00175044327
 protein coding gene Chr15:72031038-72036352 (-)
C57BL/6NJ ENSMUSG00215047837
 protein coding gene Chr15:71726304-71731612 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019884
 protein coding gene Chr15:68377857-68383182 (-)
CAST/EiJ ENSTCUG00005036270
 protein coding gene Chr15:71328927-71334241 (-)
CBA/J ENSMUSG00210034389
 protein coding gene Chr15:71806371-71811685 (-)
DBA/2J ENSMUSG00185040968
 protein coding gene Chr15:71751819-71757127 (-)
FVB/NJ ENSMUSG00205041529
 protein coding gene Chr15:71497697-71503005 (-)
JF1/MsJ ENSUMUG00000035991
 protein coding gene Chr15:71391137-71396471 (-)
LP/J ENSMUSG00230051695
 protein coding gene Chr15:75115871-75121179 (-)
NOD/ShiLtJ ENSMUSG00190048956
 protein coding gene Chr15:71862745-71868058 (-)
NZO/HlLtJ ENSMUSG00225049550
 protein coding gene Chr15:75389498-75394811 (-)
PWK/PhJ ENSLUMG00010041875
 protein coding gene Chr15:71669058-71674367 (-)
SPRET/EiJ ENSMSPG00010049033
 protein coding gene Chr15:73348642-73354018 (-)
WSB/EiJ ENSIUOG00005049243
 protein coding gene Chr15:71848507-71853810 (-)



Homology
more
  • Human Ortholog
    CYP11B1, cytochrome P450 family 11 subfamily B member 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP11B1, cytochrome P450 family 11 subfamily B member 1
  • Synonyms
    CPN1, CYP11B, FHI, P450C11
  • Links
    NCBI Gene ID: 1584
    UniProt: P15538

  • Chr Location
    8q24.3; chr8:142871528-142880000 (-)  GRCh38
  • Human Ortholog
    CYP11B2, cytochrome P450 family 11 subfamily B member 2
  • Synonyms
    ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P450aldo, P-450C18, P450C18
  • Links
    NCBI Gene ID: 1585
    UniProt: P19099

  • Chr Location
    8q24.3; chr8:142910559-142917850 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human CYP11B1,CYP11B2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some postnatal lethality, altered blood chemistry, hypotension, and abnormal adrenal cortex morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    97
  • cDNA Data
    3
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13072 NCBI Gene Model | MGI Sequence Detail 5614 C57BL/6J ±  kb
    transcript NM_009991 RefSeq | MGI Sequence Detail 1930 ZRU/MplStud  
    polypeptide P15539 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 3
      Primer pair 3
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2292, MGD-MRK-2294, MGD-MRK-2296
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 17
      Phenotypes 74
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391808 Haykir B, et al., ROR1/ROR2 regulate aldosterone production from the zona glomerulosa. Endocrinology. 2026 Jul 8;167(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory