Cyp11b2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
MGI:88584

25 phenotypes from 2 alleles in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp11b2^tm1Hsk/Cyp11b2^tm1Hsk involves: 129S6/SvEvTac	abnormal adrenal cortex morphology	J:99269
	abnormal adrenal gland zona glomerulosa morphology	J:99269
	abnormal adrenocortical cell morphology	J:99269
	decreased body weight	J:99269
	decreased circulating aldosterone level	J:99269
	decreased circulating chloride level	J:99269
	hypotension	J:99269
	increased circulating angiotensin II level	J:99269
	increased circulating corticosterone level	J:99269
	increased circulating potassium level	J:99269
	increased circulating renin level	J:99269
	increased renin activity	J:99269
	postnatal lethality, incomplete penetrance	J:99269
Cyp11b2^tm2Hsk/Cyp11b2^tm2Hsk involves: 129S6/SvEvTac	abnormal enzyme/coenzyme activity	J:147672
	abnormal response/metabolism to endogenous compounds	J:147672
	cardiac fibrosis	J:147672
	decreased fluid intake	J:147672
	decreased urine osmolality	J:147672
	hypokalemia	J:147672
	increased myocardial fiber size	J:147672
	increased systemic arterial blood pressure	J:147672
	increased urine osmolality	J:147672
	oliguria	J:147672
	oxidative stress	J:147672
	polyuria	J:147672

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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