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Ctsd
Gene Detail
 Symbol
Name
ID
Ctsd
cathepsin D
MGI:88562
Synonyms CatD, CD
Feature Type protein coding gene
Genetic Map
Chromosome 7
87.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:142371148-142388038 bp, - strand
From VEGA annotation of GRCm38

  16891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Pepsin
Gene Tree: Ctsd

Human
homologs
Human Homolog CTSD, cathepsin D
NCBI Gene ID 1509
neXtProt AC  NX_P07339
Human Synonyms  CLN10, CPSD, HEL-S-130P
Human Chr (Location)  11p15.5; chr11:1752752-1763992 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTSD
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Mice homozygous for a null mutation die in a state of anorexia at ~P26, displaying severe atrophy of the intestinal mucosa, and massive destruction of the thymus and spleen with loss of T and B cells; near the terminal stage, affected mice have seizures, display retinal atrophy, and become blind.
 
Human Diseases Modeled Using Mouse Ctsd (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process autophagic vacuole assembly, proteolysis
Component extracellular matrix, extracellular region, ...
Function aspartic-type endopeptidase activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (91)    Tissues (53)    Images (23)
Theiler Stages: 11, 13, 15, 19, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 76
Northern blot 6
Western blot 4
cDNA source data(831)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(835) Genomic(2) cDNA(832) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018797 (Evidence)
Ensembl Gene ModelENSMUSG00000007891 (Evidence)
Entrez Gene13033 (Evidence)
UniGene231395
DFCITC1573701, TC1614084
DoTSDT.101361670, DT.101361679, DT.101361841, DT.110998858, DT.87073174, DT.94214964, DT.94215031, DT.97336871, DT.97376125
NIA Mouse Gene IndexU029482
EC3.4.23.5
Consensus CDS ProjectCCDS22029.1
International Mouse Knockout Project StatusCtsd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018797 VEGA Gene Model | MGI Sequence Detail 16891 C57BL/6J ±  kb
transcript OTTMUST00000045257 VEGA | MGI Sequence Detail 2128 Not Applicable 
polypeptide OTTMUSP00000020357 VEGA | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(2) UniProt(20)
Polymorphisms RFLP(2) : SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
InterPro IPR012848 Propeptide, peptidase A1
Protein Ontology PR:000006025 cathepsin D
References (Earliest) J:12379 Qin S, et al., Mapping FSHB, CAT, and CTSB to specific sites on 11p. Cytogenet Cell Genet. 1987;46:678
(Latest) J:202510 Palmer DN, et al., NCL disease mechanisms. Biochim Biophys Acta. 2013 Nov;1832(11):1882-93
All references(100)
Other
accession IDs
MGD-MRK-2246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory