About   Help   FAQ
Ctsb Gene Detail
Summary
  • Symbol
    Ctsb
  • Name
    cathepsin B
  • Synonyms
    CB
  • Feature Type
    protein coding gene
  • IDs
    MGI:88561
    NCBI Gene: 13030
  • Gene Overview
    MyGene.info: CTSB
  • Alliance
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63122462-63145923 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88561
protein coding gene Chr14:63122462-63145923 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021456
protein coding gene Chr14:57611092-57634642 (+)
A/J MGP_AJ_G0021415
protein coding gene Chr14:56316050-56339474 (+)
AKR/J MGP_AKRJ_G0021391
protein coding gene Chr14:58326932-58350346 (+)
BALB/cJ MGP_BALBcJ_G0021421
protein coding gene Chr14:56273591-56297009 (+)
C3H/HeJ MGP_C3HHeJ_G0021198
protein coding gene Chr14:57941710-57965126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021860
protein coding gene Chr14:60369204-60392620 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019400
protein coding gene Chr14:54281338-54304245 (+)
CAST/EiJ MGP_CASTEiJ_G0020715
protein coding gene Chr14:54395469-54418617 (+)
CBA/J MGP_CBAJ_G0021165
protein coding gene Chr14:62153749-62177192 (+)
DBA/2J MGP_DBA2J_G0021288
protein coding gene Chr14:55971559-55995003 (+)
FVB/NJ MGP_FVBNJ_G0021267
protein coding gene Chr14:55389064-55412498 (+)
LP/J MGP_LPJ_G0021363
protein coding gene Chr14:58641193-58664618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021296
protein coding gene Chr14:61421890-61446221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021883
protein coding gene Chr14:57470785-57494219 (+)
PWK/PhJ MGP_PWKPhJ_G0020459
protein coding gene Chr14:52660312-52683968 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020292
protein coding gene Chr14:53445297-53468532 (+)
WSB/EiJ MGP_WSBEiJ_G0020768
protein coding gene Chr14:57794105-57817535 (+)



Homology
more
  • Human Ortholog
    CTSB, cathepsin B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CTSB, cathepsin B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APPS, CPSB, RECEUP
  • Links
    NCBI Gene ID: 1508
    neXtProt AC: NX_P07858
    UniProt: P07858

  • Chr Location
    8p23.1; chr8:11842524-11868150 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37550
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CTSB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    3 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are born normal without gross abnormalities. Homozygous mutant has resistance to induced pancreatitis. In combination with Ctsltm1Cptr, double homozygous mutant shows postnatal lethality due to wide neuronal degeneration in brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13030 NCBI Gene Model | MGI Sequence Detail 23462 C57BL/6J ±  kb
    transcript NM_007798 RefSeq | MGI Sequence Detail 4756 C57BL/6  
    polypeptide P10605 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 779
      Genomic 8
      cDNA 770
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2245
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 13
      Gene Ontology 13
      Phenotypes 68
    • Earliest
      J:8440 Chan SJ, et al., Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7721-5
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory