Csnk2a2
Gene Detail

Symbol Name ID

Csnk2a2 casein kinase 2, alpha prime polypeptide MGI:88547

Synonyms

1110035J23Rik, CK2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:95446096-95488820 bp, - strand From NCBI annotation of GRCm38   42725 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk2a2

Human homologs

Human Homolog		CSNK2A2, casein kinase 2, alpha prime polypeptide
NCBI Gene ID		1459
neXtProt AC		NX_P19784
Human Synonyms		CK2A2, CSNK2A1
Human Chr (Location)		16q21; chr16:58191811-58231782 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(2) Gene trapped(11)
 

Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	apoptotic process, cell cycle, ...
Component	nucleus, PcG protein complex, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (142)    Tissues (133)    Images (18)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	142

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(21) Primer pair(5)
Microarray probesets(11)

Other database links

Ensembl Gene Model	ENSMUSG00000046707 (Evidence)
Entrez Gene	13000 (Evidence)
DFCI	TC1577971, TC1604034, TC1643470
DoTS	DT.101737816, DT.530502
NIA Mouse Gene Index	U030136, U364868
EC	2.7.11.1
Consensus CDS Project	CCDS22562.1
International Mouse Knockout Project Status	Csnk2a2

Sequences

Length	Strain/Species
genomic	13000	NCBI Gene Model | MGI Sequence Detail	42725	C57BL/6J
transcript	NM_009974	RefSeq | MGI Sequence Detail	3766	C57BL/6
polypeptide	O54833	UniProt | EBI | MGI Sequence Detail	350	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

PCR(4) : SNPs(224 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005951	casein kinase II subunit alpha'

Graphical View of Protein Domain Structure

References

(Earliest) J:2617 Yang-Feng TL, et al., Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991 Dec;19(25):7125-9
(Latest) J:190725 Iyengar AS, et al., Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation. Biochem Biophys Res Commun. 2012 Nov 9;428(1):24-30
All references(59)

Other accession IDs

MGD-MRK-2205, MGI:1915939, MGI:2142847