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Csnk2a2
Gene Detail
Symbol

Name
ID
Csnk2a2
casein kinase 2, alpha prime polypeptide
MGI:88547
Synonyms
1110035J23Rik, CK2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:95446096-95488820 bp, - strand
From Ensembl annotation of GRCm38

  42725 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CSNK2A2
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk2a2

Human
homologs
CSNK2A2, casein kinase 2, alpha prime polypeptide
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1459
neXtProt AC: NX_P19784

Human Synonyms: CK2A2, CSNK2A1

Human Chr (Location): 16q21; chr16:58157907-58197878 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
 
Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei.
 
Interactions
Csnk2a2 interacts with 266 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process apoptotic process, cell cycle, ...
Component nucleus, PcG protein complex, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (142)    Tissues (133)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase csnk2a2 ; ZFIN csnk2a2a    NEW 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(22) Primer pair(5)
Microarray probesets(11)
Other database
links
Ensembl Gene Model ENSMUSG00000046707 (Evidence)
Entrez Gene 13000 (Evidence)
DFCI TC1577971, TC1604034, TC1643470
DoTS DT.101737816, DT.530502
NIA Mouse Gene Index U030136, U364868
EC 2.7.11.1
Consensus CDS Project CCDS22562.1
International Mouse Phenotyping Consortium Status Csnk2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046707 Ensembl Gene Model | MGI Sequence Detail 42725 C57BL/6J ±  kb
transcript ENSMUST00000056919 Ensembl | MGI Sequence Detail 3766 Not Applicable 
polypeptide ENSMUSP00000055919 Ensembl | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(4)
Polymorphisms
PCR(4) : SNPs within 2kb(246 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005951 casein kinase II subunit alpha'
References
(Earliest) J:2617 Yang-Feng TL, et al., Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991 Dec;19(25):7125-9
(Latest) J:190725 Iyengar AS, et al., Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation. Biochem Biophys Res Commun. 2012 Nov 9;428(1):24-30
All references(57)
Other
accession IDs
MGD-MRK-2205, MGI:1915939, MGI:2142847

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory