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Csnk2a2 Gene Detail
Summary
  • Symbol
    Csnk2a2
  • Name
    casein kinase 2, alpha prime polypeptide
  • Synonyms
    1110035J23Rik, CK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88547
    NCBI Gene: 13000
  • Gene Overview
    MyGene.info: CSNK2A2
Location & Maps
more
  • Sequence Map
    Chr8:95446096-95488820 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42725 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CSNK2A2, casein kinase 2 alpha 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CSNK2A2, casein kinase 2 alpha 2
    Orthology source: HomoloGene
  • Synonyms
    CK2A2, CK2alpha', CSNK2A1
  • Links
    NCBI Gene ID: 1459
    neXtProt AC: NX_P19784

  • Chr Location
    16q21; chr16:58157907-58197878 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    11
  • Targeted
    2
Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046707 Ensembl Gene Model | MGI Sequence Detail 42725 C57BL/6J ±  kb
transcript ENSMUST00000056919 Ensembl | MGI Sequence Detail 3766 Not Applicable  
polypeptide ENSMUSP00000055919 Ensembl | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    246 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 28
    Genomic 1
    cDNA 22
    Primer pair 5

    Microarray probesets 11
Other
Accession IDs
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MGD-MRK-2205, MGI:1915939, MGI:2142847
References
more
  • Summaries
    All 57
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:2617 Yang-Feng TL, et al., Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991 Dec;19(25):7125-9
  • Latest
    J:222591 Wang Y, et al., The intracellular domain of L1CAM binds to casein kinase 2alpha and is neuroprotective via inhibition of the tumor suppressors PTEN and p53. J Neurochem. 2015 Jun;133(6):828-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory