Csnk2a2^tm1Dcs
Targeted Allele Detail

Summary

• Symbol: Csnk2a2^tm1Dcs
• Name: casein kinase 2, alpha prime polypeptide; targeted mutation 1, David C Seldin
• MGI ID: MGI:2182135
• Synonyms: Csnk2a2-
• Gene: Csnk2a2 Location: Chr8:96172724-96215505 bp, - strand Genetic Position: Chr8, 47.12 cM
• Alliance: Csnk2a2^tm1Dcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57312
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5kb region, containing the promoter region and exons 1 and 2, was replaced by a neomycin selection cassette. The deleted region encoded the start codon and the ATP-binding domain. Northern and Western blot analyses of testicular tissue showed a lack of transcript and protein in homozygous mutant mice. (J:57312)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csnk2a2 Mutation: 22 strains or lines available

References

• Original: J:57312 Xu X, et al., Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Nat Genet. 1999 Sep;23(1):118-21
• All: 4 reference(s)