About   Help   FAQ
Cryba1 Gene Detail
Summary
  • Symbol
    Cryba1
  • Name
    crystallin, beta A1
  • Synonyms
    BA3/A1, Cryb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88518
    NCBI Gene: 12957
Location & Maps
more
  • Sequence Map
    Chr11:77718615-77725283 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6669 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B-C1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    CRYBA1, crystallin beta A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYBA1, crystallin beta A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRYB1, CTRCT10
  • Links
    NCBI Gene ID: 1411
    neXtProt AC: NX_P05813

  • Chr Location
    17q11.2; chr17:29246857-29254494 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Cryba1 mouse models; 1 with human CRYBA1 associations

Human Disease Mouse Models
       Cataract 10, Multiple Types; CTRCT10   OMIM: 600881 View 2 models
       Macular Degeneration, Age-Related, 1; ARMD1   OMIM: 603075 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Targeted
    5
  • Genomic Mutations
    2 involving Cryba1
  • Incidental Mutations
Heterozygotes for an ethylnitrosourea-induced mutation exhibit a zonular opacity when the eyes open at age 12 days, progressing to total opacity by eight weeks. Homozygotes exhibit microphthalmia, and complete lens opacity by 12 days.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008185 VEGA Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
transcript OTTMUST00000018594 VEGA | MGI Sequence Detail 778 Not Applicable  
polypeptide OTTMUSP00000008544 VEGA | MGI Sequence Detail 215 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    10 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 216
    Genomic 2
    cDNA 210
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2165, MGD-MRK-2167
References
more
  • Summaries
    All 59
    Developmental Gene Expression 19
    Diseases 2
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:20244 Inana G, et al., Evolution and diversity of the crystallins. Nucleotide sequence of a beta-crystallin mRNA from the mouse lens. J Biol Chem. 1982 Aug 10;257(15):9064-71
  • Latest
    J:215838 Valapala M, et al., Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/betaA3/A1-crystallin via V-ATPase-MTORC1 signaling. Autophagy. 2014 Mar;10(3):480-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory