Cryba1
Gene Detail

Symbol Name ID

Cryba1 crystallin, beta A1 MGI:88518

Synonyms

BA3/A1, Cryb

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.74 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:77718615-77725283 bp, - strand From VEGA annotation of GRCm38   6669 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryba1

Human homologs

Human Homolog		CRYBA1, crystallin, beta A1
NCBI Gene ID		1411
neXtProt AC		NX_P05813
Human Synonyms		CRYB1
Human Chr (Location)		17q11.2; chr17:27573875-27581512 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CRYBA1

Alleles and phenotypes

All alleles(20) : Targeted(3) Gene trapped(16) Chemically induced(1)
 

Heterozygotes for an ethylnitrosourea-induced mutation exhibit a zonular opacity when the eyes open at age 12 days, progressing to total opacity by eight weeks. Homozygotes exhibit microphthalmia, and complete lens opacity by 12 days.

 
Human Diseases Modeled Using Mouse Cryba1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	camera-type eye development, visual perception
Component	cytoplasm, nucleus
Function	protein homodimerization activity, structural constituent of eye lens

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (29)    Tissues (11)    Images (4)
Theiler Stages: 16, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	1
RT-PCR	28

cDNA source data(210)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(217) Genomic(2) cDNA(211) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008185 (Evidence)
Ensembl Gene Model	ENSMUSG00000000724 (Evidence)
Entrez Gene	12957 (Evidence)
UniGene	22830
DFCI	TC1572602, TC1764482
DoTS	DT.101253305, DT.101710648, DT.94140986, DT.99859679, DT.99859681
NIA Mouse Gene Index	U033110
Consensus CDS Project	CCDS25084.1
International Mouse Knockout Project Status	Cryba1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008185	VEGA Gene Model | MGI Sequence Detail	6669	C57BL/6J
transcript	OTTMUST00000018594	VEGA | MGI Sequence Detail	778	Not Applicable
polypeptide	OTTMUSP00000008544	VEGA | MGI Sequence Detail	215	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(7) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001064	Beta/gamma crystallin
InterPro	IPR011024	Gamma-crystallin-related
Protein Ontology	PR:000029369	beta-crystallin A3

References

(Earliest) J:20244 Inana G, et al., Evolution and diversity of the crystallins. Nucleotide sequence of a beta-crystallin mRNA from the mouse lens. J Biol Chem. 1982 Aug 10;257(15):9064-71
(Latest) J:193107 Jin C, et al., Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013 Feb 1;374(1):96-107
All references(63)

Other accession IDs

MGD-MRK-2165, MGD-MRK-2167