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Cryba1 Gene Detail
Summary
  • Symbol
    Cryba1
  • Name
    crystallin, beta A1
  • Synonyms
    BA3/A1, Cryb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88518
    NCBI Gene: 12957
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:77718615-77725283 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B-C1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88518
protein coding gene Chr11:77718614-77725293 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018754
protein coding gene Chr11:78659759-78667762 (-)
A/J MGP_AJ_G0018720
protein coding gene Chr11:75668823-75675506 (-)
AKR/J MGP_AKRJ_G0018690
protein coding gene Chr11:77969522-77976190 (-)
BALB/cJ MGP_BALBcJ_G0018694
protein coding gene Chr11:76064254-76070900 (-)
C3H/HeJ MGP_C3HHeJ_G0018507
protein coding gene Chr11:78004001-78010669 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019145
protein coding gene Chr11:81130875-81138857 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016780
protein coding gene Chr11:72644008-72650980 (-)
CAST/EiJ MGP_CASTEiJ_G0018061
protein coding gene Chr11:78414281-78420997 (-)
CBA/J MGP_CBAJ_G0018477
protein coding gene Chr11:84661219-84670907 (-)
DBA/2J MGP_DBA2J_G0018586
protein coding gene Chr11:75255749-75262517 (-)
FVB/NJ MGP_FVBNJ_G0018576
protein coding gene Chr11:74835701-74842338 (-)
LP/J MGP_LPJ_G0018657
protein coding gene Chr11:79211775-79218423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018602
protein coding gene Chr11:85108233-85116349 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019185
protein coding gene Chr11:78194311-78200952 (-)
PWK/PhJ MGP_PWKPhJ_G0017832
protein coding gene Chr11:76017379-76024188 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017623
protein coding gene Chr11:77792179-77798811 (-)
WSB/EiJ MGP_WSBEiJ_G0018114
protein coding gene Chr11:78012031-78019489 (-)



Homology
more
  • Human Ortholog
    CRYBA1, crystallin beta A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYBA1, crystallin beta A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRYB1, CTRCT10
  • Links
    NCBI Gene ID: 1411
    neXtProt AC: NX_P05813
    UniProt: P05813

  • Chr Location
    17q11.2; chr17:29246857-29254494 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Cryba1 mouse models; 1 with human CRYBA1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    8 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele exhibit microphthalmia, congenital nuclear cataracts, persistent hyaloid artery, and lens defects including impaired lysosomal cargo clearance, increased calcium level, and cytoskeletal defects. Homozygotes for an ENU allele show microphthalmia and total cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000724 Ensembl Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
    transcript ENSMUST00000078623 Ensembl | MGI Sequence Detail 778 Not Applicable  
    polypeptide ENSMUSP00000077693 Ensembl | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001064 Beta/gamma crystallin
      IPR011024 Gamma-crystallin-like
    Molecular
    Reagents
    less
    • All nucleic 217
      Genomic 2
      cDNA 211
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2165, MGD-MRK-2167
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264290 Ghosh S, et al., A Role for betaA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2018 Mar 20;59(4):AMD104-AMD113

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory