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Cryba1
Gene Detail
 Symbol
Name
ID
Cryba1
crystallin, beta A1
MGI:88518
Synonyms BA3/A1, Cryb
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:77718615-77725283 bp, - strand
From VEGA annotation of GRCm38

  6669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryba1

Human
homologs
Human Homolog CRYBA1, crystallin, beta A1
NCBI Gene ID 1411
neXtProt AC  NX_P05813
Human Synonyms  CRYB1, CTRCT10
Human Chr (Location)  17q11.2; chr17:29246857-29254494 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRYBA1
Alleles
and
phenotypes
All alleles(20) : Chemically induced (ENU)(1) Gene trapped(16) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygotes for an ethylnitrosourea-induced mutation exhibit a zonular opacity when the eyes open at age 12 days, progressing to total opacity by eight weeks. Homozygotes exhibit microphthalmia, and complete lens opacity by 12 days.
 
Human Diseases Modeled Using Mouse Cryba1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process camera-type eye development, visual perception
Component cytoplasm, nucleus
Function protein homodimerization activity, structural constituent of eye lens
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (29)    Tissues (11)    Images (4)
Theiler Stages: 16, 17, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 1
RT-PCR 28
cDNA source data(209)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(216) Genomic(2) cDNA(210) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008185 (Evidence)
Ensembl Gene ModelENSMUSG00000000724 (Evidence)
Entrez Gene12957 (Evidence)
UniGene22830
DFCITC1572602, TC1764482
DoTSDT.101253305, DT.101710648, DT.94140986, DT.99859679, DT.99859681
NIA Mouse Gene IndexU033110
Consensus CDS ProjectCCDS25084.1
International Mouse Knockout Project StatusCryba1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008185 VEGA Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
transcript OTTMUST00000018594 VEGA | MGI Sequence Detail 778 Not Applicable 
polypeptide OTTMUSP00000008544 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms RFLP(7) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000029369 beta-crystallin A3
References (Earliest) J:20244 Inana G, et al., Evolution and diversity of the crystallins. Nucleotide sequence of a beta-crystallin mRNA from the mouse lens. J Biol Chem. 1982 Aug 10;257(15):9064-71
(Latest) J:193107 Jin C, et al., Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013 Feb 1;374(1):96-107
All references(64)
Other
accession IDs
MGD-MRK-2165, MGD-MRK-2167

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory