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Cryba1
Gene Detail
Symbol

Name
ID
Cryba1
crystallin, beta A1
MGI:88518
Synonyms
BA3/A1, Cryb
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:77718615-77725283 bp, - strand
From VEGA annotation of GRCm38

  6669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRYBA1
Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryba1

Human
homologs
CRYBA1, crystallin, beta A1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1411
neXtProt AC: NX_P05813

Human Synonyms: CRYB1, CTRCT10

Human Chr (Location): 17q11.2; chr17:29246857-29254494 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYBA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(1) Gene trapped(16) Targeted(5)
Genomic Mutations involving Cryba1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygotes for an ethylnitrosourea-induced mutation exhibit a zonular opacity when the eyes open at age 12 days, progressing to total opacity by eight weeks. Homozygotes exhibit microphthalmia, and complete lens opacity by 12 days.
 
Human Diseases Modeled in Mice Using Cryba1 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Cryba1 interacts with 31 markers (Mir130b, Mir137, Mir138-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (29)    Tissues (12)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 28
cDNA source data(209)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cryba1 ; ZFIN cryba1a, cryba1b    NEW 
Molecular
reagents
All nucleic(216) Genomic(2) cDNA(210) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008185 (Evidence)
Ensembl Gene Model ENSMUSG00000000724 (Evidence)
Entrez Gene 12957 (Evidence)
UniGene 22830
DFCI TC1572602, TC1764482
DoTS DT.101253305, DT.101710648, DT.94140986, DT.99859679, DT.99859681
NIA Mouse Gene Index U033110
Consensus CDS Project CCDS25084.1
International Mouse Phenotyping Consortium Status Cryba1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008185 VEGA Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
transcript OTTMUST00000018594 VEGA | MGI Sequence Detail 778 Not Applicable 
polypeptide OTTMUSP00000008544 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(7) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000029369 beta-crystallin A3
References
(Earliest) J:20244 Inana G, et al., Evolution and diversity of the crystallins. Nucleotide sequence of a beta-crystallin mRNA from the mouse lens. J Biol Chem. 1982 Aug 10;257(15):9064-71
(Latest) J:215838 Valapala M, et al., Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/betaA3/A1-crystallin via V-ATPase-MTORC1 signaling. Autophagy. 2014 Mar;10(3):480-96
All references(62)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2165, MGD-MRK-2167

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory