Cryba1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cryba1
crystallin, beta A1
MGI:88518

24 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cryba1^Po1/Cryba1⁺ C3HeB/FeJ-Cryba1^Po1	total cataract	J:58912
Cryba1^Po1/Cryba1^Po1 C3HeB/FeJ-Cryba1^Po1	microphthalmia	J:58912
Cryba1^Po1/Cryba1^Po1 C3HeB/FeJ-Cryba1^Po1	total cataract	J:58912
Cryba1^tm1.1Dbsa/Cryba1^tm1.1Dbsa Tg(BEST1-cre)1Jdun/0 involves: 129S6/SvEvTac * C57BL/6	abnormal lysosome morphology	J:215838
	abnormal lysosome physiology	J:215838
	abnormal retina pigment epithelium morphology	J:215531, J:215838
	abnormal retina pigmentation	J:215838
	decreased a-wave amplitude	J:215838
	decreased b-wave amplitude	J:215838
	gliosis	J:215531
	impaired autophagy	J:215838
	increased susceptibility to age-related retinal degeneration	J:215531
	lysosomal protein accumulation	J:215531
Cryba1^{tm1a(EUCOMM)Hmgu}/Cryba1^{tm1a(EUCOMM)Hmgu} involves: C57BL/6J * C57BL/6N	abnormal autophagy	J:235696
	abnormal calcium ion homeostasis	J:235696
	abnormal cell cytoskeleton morphology	J:235696
	abnormal enzyme/coenzyme activity	J:235696
	abnormal lens epithelium morphology	J:235696
	abnormal lens fiber morphology	J:235696
	abnormal lens morphology	J:235696
	abnormal lysosome morphology	J:235696
	abnormal lysosome physiology	J:235696
	developmental cataract	J:235696
	increased mitochondrial number	J:235696
	microphthalmia	J:235696
	nuclear cataract	J:235696
	persistent hyaloid artery	J:235696
	small lens	J:235696

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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