Cryab
Gene Detail

Symbol Name ID

Cryab crystallin, alpha B MGI:88516

STS

D9Mit96

Synonyms

alpha B-crystallin, Crya2, Crya-2, HspB5

Feature Type

protein coding gene

Genetic Map

Chromosome 9

27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:50752758-50756633 bp, + strand From NCBI annotation of GRCm38   3876 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68209  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-crystallin
Gene Tree: Cryab

Human homologs

Human Homolog		CRYAB, crystallin, alpha B
NCBI Gene ID		1410
neXtProt AC		NX_P02511
Human Synonyms		CMD1II, CRYA2, CTPP2, HSPB5
Human Chr (Location)		11q22.3-q23.1; chr11:111779350-111782473 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CRYAB

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous or heterozygous for a knock-in allele exhibit decreased grip strength and develop cataracts and myopathy; some mice display unilateral corneal abnormalities and small eyes.

 
Human Diseases Modeled Using Mouse Cryab (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	apoptotic process involved in morphogenesis, camera-type eye development, ...
Component	actin filament bundle, cell surface, ...
Function	cytoskeletal protein binding, metal ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (131)    Tissues (40)    Images (43)
Theiler Stages: 12, 19, 20, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	121
RT-PCR	6

cDNA source data(185)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(192) Genomic(1) cDNA(185) Primer pair(3) Other(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000032060 (Evidence)
Entrez Gene	12955 (Evidence)
UniGene	178
DFCI	TC1572066, TC1591113, TC1594100
DoTS	DT.101298390, DT.101298394, DT.91448106, DT.94371013
NIA Mouse Gene Index	U010466
Consensus CDS Project	CCDS23172.1
International Mouse Knockout Project Status	Cryab

Sequences

Length	Strain/Species
genomic	12955	NCBI Gene Model | MGI Sequence Detail	3876	C57BL/6J
transcript	NM_009964	RefSeq | MGI Sequence Detail	1185	C57BL/6
polypeptide	P23927	UniProt | EBI | MGI Sequence Detail	175	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(48 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001436	Alpha crystallin/Heat shock protein
InterPro	IPR002068	Alpha crystallin/Hsp20 domain
InterPro	IPR003090	Alpha-crystallin, N-terminal
InterPro	IPR012273	Alpha-crystallin, subunit B
InterPro	IPR008978	HSP20-like chaperone
Protein Ontology	PR:000005908	alpha-crystallin B chain

Graphical View of Protein Domain Structure

References

(Earliest) J:19955 Quax-Jeuken Y, et al., Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5819-23
(Latest) J:188048 Dou G, et al., Deficiency of alphaB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 1;53(5):1111-22
All references(124)

Other accession IDs

MGD-MRK-2161, MGD-MRK-2163