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Cryab Gene Detail
Summary
  • Symbol
    Cryab
  • Name
    crystallin, alpha B
  • Synonyms
    alpha B-crystallin, Crya2, Crya-2, HspB5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88516
    NCBI Gene: 12955
  • Gene Overview
    MyGene.info: CRYAB
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50751325-50756636 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    5 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88516
protein coding gene Chr9:50751325-50756636 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034789
protein coding gene Chr9:49652484-49656378 (+)
A/J MGP_AJ_G0034770
protein coding gene Chr9:48139981-48143870 (+)
AKR/J MGP_AKRJ_G0034698
protein coding gene Chr9:49150266-49154141 (+)
BALB/cJ MGP_BALBcJ_G0034762
protein coding gene Chr9:47864806-47868695 (+)
C3H/HeJ MGP_C3HHeJ_G0034472
protein coding gene Chr9:49639683-49643572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035282
protein coding gene Chr9:51035642-51039517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032195
protein coding gene Chr9:47600733-47604642 (+)
CAST/EiJ MGP_CASTEiJ_G0033794
protein coding gene Chr9:49586966-49590867 (+)
CBA/J MGP_CBAJ_G0034444
protein coding gene Chr9:52843618-52847513 (+)
DBA/2J MGP_DBA2J_G0034603
protein coding gene Chr9:47998813-48002702 (+)
FVB/NJ MGP_FVBNJ_G0034544
protein coding gene Chr9:47214346-47218221 (+)
LP/J MGP_LPJ_G0034684
protein coding gene Chr9:50010179-50014073 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034587
protein coding gene Chr9:54442178-54446067 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035303
protein coding gene Chr9:49130742-49134631 (+)
PWK/PhJ MGP_PWKPhJ_G0033499
protein coding gene Chr9:47976552-47980516 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033334
protein coding gene Chr9:49435253-49439157 (+)
WSB/EiJ MGP_WSBEiJ_G0033907
protein coding gene Chr9:49135762-49139637 (+)



Homology
more
  • Human Ortholog
    CRYAB, crystallin alpha B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYAB, crystallin alpha B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
  • Links
    NCBI Gene ID: 1410
    neXtProt AC: NX_P02511
    UniProt: P02511

  • Chr Location
    11q23.1; chr11:111908620-111913213 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Cryab mouse models; 4 with human CRYAB associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    22 phenotypes from multigenic genotypes
    2 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a knock-in allele exhibit decreased grip strength and develop cataracts and myopathy; some mice display unilateral corneal abnormalities and small eyes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12955 NCBI Gene Model | MGI Sequence Detail 5312 C57BL/6J ±  kb
    transcript NM_001289782 RefSeq | MGI Sequence Detail 1117 C57BL/6  
    polypeptide P23927 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 198
      Genomic 1
      cDNA 188
      Primer pair 5
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2161, MGD-MRK-2163
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 49
      Diseases 4
      Gene Ontology 17
      Phenotypes 57
    • Earliest
      J:19955 Quax-Jeuken Y, et al., Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5819-23
    • Latest
      J:263025 Zoupa M, et al., Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory