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Cryab Gene Detail
Summary
  • Symbol
    Cryab
  • Name
    crystallin, alpha B
  • Synonyms
    alpha B-crystallin, Crya-2, Crya2, HspB5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88516
    NCBI Gene: 12955
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50662625-50667936 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88516
 protein coding gene Chr9:50657251-50667936 (+)
129S1/SvImJ ENSMUSG00200017962
 protein coding gene Chr9:47827340-47832660 (+)
A/J ENSMUSG00195019747
 protein coding gene Chr9:47517057-47522382 (+)
AKR/J ENSMUSG00220035248
 protein coding gene Chr9:47607761-47613072 (+)
BALB/cJ ENSMUSG00180029513
 protein coding gene Chr9:47628445-47633771 (+)
C3H/HeJ ENSMUSG00175014791
 protein coding gene Chr9:47640479-47645804 (+)
C57BL/6NJ ENSMUSG00215018408
 protein coding gene Chr9:47590061-47595372 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032195
 protein coding gene Chr9:47600733-47604642 (+)
CAST/EiJ ENSTCUG00005014874
 protein coding gene Chr9:47547851-47553183 (+)
CBA/J ENSMUSG00210016420
 protein coding gene Chr9:47706358-47711686 (+)
DBA/2J ENSMUSG00185009633
 protein coding gene Chr9:47754929-47760252 (+)
FVB/NJ ENSMUSG00205033219
 protein coding gene Chr9:47982167-47987478 (+)
JF1/MsJ ENSUMUG00000031701
 protein coding gene Chr9:47803941-47809265 (+)
LP/J ENSMUSG00230040559
 protein coding gene Chr9:48043125-48048445 (+)
NOD/ShiLtJ ENSMUSG00190018067
 protein coding gene Chr9:47835019-47840343 (+)
NZO/HlLtJ ENSMUSG00225042850
 protein coding gene Chr9:48010776-48016099 (+)
PWK/PhJ ENSLUMG00010020191
 protein coding gene Chr9:47775408-47780719 (+)
SPRET/EiJ ENSMSPG00010010567
 protein coding gene Chr9:48585509-48589269 (+)
WSB/EiJ ENSIUOG00005017943
 protein coding gene Chr9:47249351-47254662 (+)



Homology
more
  • Human Ortholog
    CRYAB, crystallin alpha B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYAB, crystallin alpha B
  • Synonyms
    CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2, MFM2A, MFM2B
  • Links
    NCBI Gene ID: 1410
    UniProt: P02511

  • Chr Location
    11q23.1; chr11:111908564-111923740 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cryab mouse models; 4 with human CRYAB associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a knock-in allele exhibit decreased grip strength and develop cataracts and myopathy; some mice display unilateral corneal abnormalities and small eyes. Homozygosity for the p.R123W mutation leads to hypertrophic cardiomyopathy after trans-aortic constriction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    113
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    124
  • cDNA Data
    187
  • Literature Summary
    63
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032060 Ensembl Gene Model | MGI Sequence Detail 5312 C57BL/6J ±  kb
    transcript ENSMUST00000034562 Ensembl | MGI Sequence Detail 946 Not Applicable  
    polypeptide ENSMUSP00000034562 Ensembl | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005908 alpha-crystallin B chain
      (term hierarchy)
    • InterPro Domains
      IPR037882 Alpha-crystallin B chain, ACD domain
      IPR055269 Alpha crystallin/Heat shock protein Hsp-16.1/Hsp-16.2
      IPR002068 Alpha crystallin/Hsp20 domain
      IPR003090 Alpha-crystallin, N-terminal
      IPR001436 Alpha crystallin/Small heat shock protein, animal type
      IPR008978 HSP20-like chaperone
    • GlyGen
      P23927 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 199
      Genomic 1
      cDNA 188
      Primer pair 6
      Other 4
      Antibodies 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2161, MGD-MRK-2163
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 63
      Diseases 4
      Gene Ontology 23
      Phenotypes 82
    • Earliest
      J:19955 Quax-Jeuken Y, et al., Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5819-23
    • Latest
      J:384798 Rayee D, et al., RNA-binding proteins in the mouse lens: Functional classifications, expression profiling, and interaction studies of Carhsp1 with crystallin mRNAs. Dev Biol. 2026 Apr 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory