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Cryab
Gene Detail
 Symbol
Name
ID
Cryab
crystallin, alpha B
MGI:88516
STS D9Mit96
Synonyms alpha B-crystallin, Crya2, Crya-2, HspB5
Feature Type protein coding gene
Genetic Map
Chromosome 9
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:50752758-50756633 bp, + strand
From NCBI annotation of GRCm38

  3876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68209  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-crystallin
Gene Tree: Cryab

Human
homologs
Human Homolog CRYAB, crystallin, alpha B
NCBI Gene ID 1410
neXtProt AC  NX_P02511
Human Synonyms  CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
Human Chr (Location)  11q22.3-q23.1; chr11:111908626-111911749 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CRYAB
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous or heterozygous for a knock-in allele exhibit decreased grip strength and develop cataracts and myopathy; some mice display unilateral corneal abnormalities and small eyes.
 
Human Diseases Modeled Using Mouse Cryab (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Cryab interacts with 31 markers (Mir27a, Mir27b, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic process involved in morphogenesis, camera-type eye development, ...
Component actin filament bundle, cell surface, ...
Function cytoskeletal protein binding, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (131)    Tissues (40)    Images (43)
Theiler Stages: 12, 19, 20, 23, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 121
RT-PCR 6
cDNA source data(185)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(192) Genomic(1) cDNA(185) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032060 (Evidence)
Entrez Gene12955 (Evidence)
UniGene178
DFCITC1572066, TC1591113, TC1594100
DoTSDT.101298390, DT.101298394, DT.91448106, DT.94371013
NIA Mouse Gene IndexU010466
Consensus CDS ProjectCCDS23172.1
International Mouse Knockout Project StatusCryab
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12955 NCBI Gene Model | MGI Sequence Detail 3876 C57BL/6J ±  kb
transcript NM_001289782 RefSeq | MGI Sequence Detail 1117 C57BL/6 
polypeptide P23927 UniProt | EBI | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR003090 Alpha-crystallin, N-terminal
InterPro IPR012273 Alpha-crystallin, subunit B
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000005908 alpha-crystallin B chain
Graphical View of Protein Domain Structure
References (Earliest) J:19955 Quax-Jeuken Y, et al., Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5819-23
(Latest) J:210399 Wignes JA, et al., p62 expression and autophagy in alphaB-crystallin R120G mutant knock-in mouse model of hereditary cataract. Exp Eye Res. 2013 Oct;115:263-73
All references(132)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2161, MGD-MRK-2163

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory