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Cryab
Gene Detail
Symbol

Name
ID
Cryab
crystallin, alpha B
MGI:88516
STS
Synonyms
alpha B-crystallin, Crya2, Crya-2, HspB5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:50752758-50756633 bp, + strand
From Ensembl annotation of GRCm38

  3876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68209  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRYAB
Protein SuperFamily: alpha-crystallin
Gene Tree: Cryab

Human
homologs
CRYAB, crystallin, alpha B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1410
neXtProt AC: NX_P02511

Human Synonyms: CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2

Human Chr (Location): 11q22.3-q23.1; chr11:111908620-111913213 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CRYAB

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(4) Transgenic(1)
Genomic Mutations involving Cryab (1)
Incidental mutations (data from APF )
 
Mice homozygous or heterozygous for a knock-in allele exhibit decreased grip strength and develop cataracts and myopathy; some mice display unilateral corneal abnormalities and small eyes.
 
Human Diseases Modeled in Mice Using Cryab (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Cryab interacts with 31 markers (Mir27a, Mir27b, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (42 records)
Data Summary: Results (131)    Tissues (40)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 121
RT-PCR 6
cDNA source data(185)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cryab ; ZFIN cryaba    NEW 
Molecular
reagents
All nucleic(192) Genomic(1) cDNA(185) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000032060 (Evidence)
Entrez Gene 12955 (Evidence)
UniGene 178
DFCI TC1572066, TC1591113, TC1594100
DoTS DT.101298390, DT.101298394, DT.91448106, DT.94371013
NIA Mouse Gene Index U010466
Consensus CDS Project CCDS23172.1
International Mouse Phenotyping Consortium Status Cryab
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032060 Ensembl Gene Model | MGI Sequence Detail 3876 C57BL/6J ±  kb
transcript ENSMUST00000034562 Ensembl | MGI Sequence Detail 1185 Not Applicable 
polypeptide ENSMUSP00000034562 Ensembl | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR003090 Alpha-crystallin, N-terminal
InterPro IPR012273 Alpha-crystallin, subunit B
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000005908 alpha-crystallin B chain
References
(Earliest) J:19955 Quax-Jeuken Y, et al., Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5819-23
(Latest) J:217342 Zhou P, et al., Protection of retina by alphaB crystallin in sodium iodate induced retinal degeneration. PLoS One. 2014;9(5):e98275
All references(117)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2161, MGD-MRK-2163

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory