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Crk Gene Detail
Summary
  • Symbol
    Crk
  • Name
    v-crk avian sarcoma virus CT10 oncogene homolog
  • Synonyms
    Crk-I, Crk-II, Crk-III, Crko, proto-oncogene c-crk
  • Feature Type
    protein coding gene
  • IDs
    MGI:88508
    NCBI Gene: 12928
  • Gene Overview
    MyGene.info: CRK
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75679259-75706908 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband A-D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88508
protein coding gene Chr11:75679248-75708428 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018721
protein coding gene Chr11:76447687-76475278 (+)
A/J MGP_AJ_G0018687
protein coding gene Chr11:73598410-73626788 (+)
AKR/J MGP_AKRJ_G0018657
protein coding gene Chr11:75824929-75853362 (+)
BALB/cJ MGP_BALBcJ_G0018661
protein coding gene Chr11:73979280-74006394 (+)
C3H/HeJ MGP_C3HHeJ_G0018474
protein coding gene Chr11:75845229-75873091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019112
protein coding gene Chr11:78864350-78895368 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016747
protein coding gene Chr11:70610445-70638640 (+)
CAST/EiJ MGP_CASTEiJ_G0018028
protein coding gene Chr11:76240438-76271092 (+)
CBA/J MGP_CBAJ_G0018444
protein coding gene Chr11:82316032-82348493 (+)
DBA/2J MGP_DBA2J_G0018553
protein coding gene Chr11:73202398-73229784 (+)
FVB/NJ MGP_FVBNJ_G0018543
protein coding gene Chr11:72764623-72791976 (+)
LP/J MGP_LPJ_G0018624
protein coding gene Chr11:77030580-77058642 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018569
protein coding gene Chr11:82848427-82877318 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019152
protein coding gene Chr11:76042876-76069987 (+)
PWK/PhJ MGP_PWKPhJ_G0017799
protein coding gene Chr11:73909963-73940724 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017590
protein coding gene Chr11:75593556-75623678 (+)
WSB/EiJ MGP_WSBEiJ_G0018081
protein coding gene Chr11:75854048-75883993 (+)



Homology
more
  • Human Ortholog
    CRK, CRK proto-oncogene, adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRK, CRK proto-oncogene, adaptor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRKII, p38
  • Links
    NCBI Gene ID: 1398
    neXtProt AC: NX_P46108
    UniProt: P46108

  • Chr Location
    17p13.3; chr17:1421353-1456267 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 81850
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRK
  • Gene Tree
    Crk
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an isoform specific knockout do not exhibit any obvious abnormalities. Mice homozygous of a null allele of both isoforms exhibit fetal and perinatal lethality associated with abnormal cardiovascular morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017776 Ensembl Gene Model | MGI Sequence Detail 27650 C57BL/6J ±  kb
    transcript ENSMUST00000017920 Ensembl | MGI Sequence Detail 3642 Not Applicable  
    polypeptide ENSMUSP00000017920 Ensembl | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 3
      cDNA 30
      Primer pair 2
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-2151
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 16
      Gene Ontology 20
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260356 Aiello FB, et al., IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Cell Signal. 2018 Jul;47:131-141

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory