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Crk
Gene Detail
 Symbol
Name
ID
Crk
v-crk sarcoma virus CT10 oncogene homolog (avian)
MGI:88508
Synonyms Crk-I, Crk-II, Crk-III, Crko, proto-oncogene c-crk
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.92 cM, cytoband A-D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:75679259-75706908 bp, + strand
From VEGA annotation of GRCm38

  27650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Crk

Human
homologs
Human Homolog CRK, v-crk avian sarcoma virus CT10 oncogene homolog
NCBI Gene ID 1398
neXtProt AC  NX_P46108
Human Synonyms  CRKII, p38
Human Chr (Location)  17p13.3; chr17:1421353-1456267 (-)  GRCh38
Alleles
and
phenotypes
All alleles(35) : Gene trapped(31) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an isoform specific knockout do not exhibit any obvious abnormalities. Mice homozygous of a null allele of both isoforms exhibit fetal and perinatal lethality associated with abnormal cardiovascular morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process ephrin receptor signaling pathway, phosphorylation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function ephrin receptor binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (133)    Tissues (68)    Images (16)
Theiler Stages: 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 49
Western blot 48
RT-PCR 18
RNase protection 18
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(3) cDNA(27) Primer pair(2) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000006211 (Evidence)
Ensembl Gene ModelENSMUSG00000017776 (Evidence)
Entrez Gene12928 (Evidence)
DFCITC1574896, TC1588101, TC1596486, TC1654583
DoTSDT.494033, DT.101386807, DT.101737472, DT.101737473, DT.110535024, DT.99860774
NIA Mouse Gene IndexU012958
PDB1CKA, 1CKB, 1M3A, 1M3B, 1M3C, 2GGR, 1B07, 1JU5, 1M30
Consensus CDS ProjectCCDS25055.1, CCDS70241.1, CCDS70242.1
International Mouse Knockout Project StatusCrk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006211 VEGA Gene Model | MGI Sequence Detail 27650 C57BL/6J ±  kb
transcript OTTMUST00000014007 VEGA | MGI Sequence Detail 3642 Not Applicable 
polypeptide OTTMUSP00000006506 VEGA | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(10) UniProt(9)
Polymorphisms SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000005882 adapter molecule crk
References (Earliest) J:19716 Mayer BJ, et al., A novel viral oncogene with structural similarity to phospholipase C. Nature. 1988 Mar 17;332(6161):272-5
(Latest) J:184498 George B, et al., Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb 1;122(2):674-92
All references(68)
Other
accession IDs
MGD-MRK-2151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory