Crhr1 MGI Mouse Gene Detail - MGI:88498 - corticotropin releasing hormone receptor 1

Crhr1 Gene Detail

Symbol

Crhr1
Name

corticotropin releasing hormone receptor 1
Synonyms

CRF1R, CRF 1 receptor, CRFR1, CRF-R1alpha

Feature Type

protein coding gene
IDs

MGI:88498
NCBI Gene: 12921

Sequence Map

Chr11:104132855-104175523 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

42669 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.77 cM
Mapping Data

10 experiments

Human Ortholog

CRHR1, corticotropin releasing hormone receptor 1

Vertebrate Orthologs

10

Human Ortholog

CRHR1, corticotropin releasing hormone receptor 1
Orthology source: HomoloGene, HGNC
Synonyms

CRF1, CRF-R, CRFR1, CRF-R1, CRF-R-1, CRFR-1, CRHR, CRH-R1, CRH-R-1, CRHR1L
Links

HGNC:2357

NCBI Gene ID: 1394

neXtProt AC: NX_P34998
Chr Location

17q21.31; chr17:45784280-45835828 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 20920
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CRHR1
Protein SuperFamily

G protein-coupled receptor, peptide hormone receptor type
Gene Tree

Crhr1

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Phenotype Summary

31 phenotypes from 8 alleles in 10 genetic backgrounds
5 phenotypes from multigenic genotypes
62 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Targeted

12
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.

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All GO Annotations

59
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

6
Tissues

2
cDNA Data

14
Literature Summary

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

GEISHA CRHR1

Xenbase crhr1.1, crhr1.2

ZFIN crhr1

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Crhr1 interacts with 114 markers (Mir17, Mir18, Mir18b, ...) View All

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All Sequences

44
RefSeq

13
UniProt

6
CCDS

CCDS25526.1
UniGene

1892

			Length	Strain/Species	Flank
genomic	OTTMUSG00000003151	VEGA Gene Model \| MGI Sequence Detail	42669	C57BL/6J	± kb
transcript	OTTMUST00000006508	VEGA \| MGI Sequence Detail	2460	Not Applicable
polypeptide	OTTMUSP00000003077	VEGA \| MGI Sequence Detail	415	Not Applicable

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SNPs within 2kb

502 from dbSNP Build 142

RFLP

1

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UniProt

6 Sequences
Protein Ontology

PR:000005869 corticotropin-releasing factor receptor 1
InterPro Domains

IPR003051 GPCR, family 2, corticotropin releasing factor receptor

IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR017981 GPCR, family 2-like

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

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All nucleic 27

Genomic 3

cDNA 15

Primer pair 9

Microarray probesets 4

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MGD-MRK-2141

Summaries

All 119

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 62
Earliest

J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
Latest

J:233427 Garcia-Carmona JA, et al., Sex differences between CRF1 receptor deficient mice following naloxone-precipitated morphine withdrawal in a conditioned place aversion paradigm: implication of HPA axis. PLoS One. 2015;10(4):e0121125

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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