About   Help   FAQ
Crhr1
Gene Detail
Symbol

Name
ID
Crhr1
corticotropin releasing hormone receptor 1
MGI:88498
Synonyms
CRF 1 receptor, CRFR1, CRF-R1alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 11
67.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:104132855-104175523 bp, + strand
From VEGA annotation of GRCm38

  42669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRHR1
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Crhr1

Human
homologs
CRHR1, corticotropin releasing hormone receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1394
neXtProt AC: NX_P34998

Human Synonyms: CRF1, CRF-R, CRFR1, CRF-R1, CRF-R-1, CRFR-1, CRHR, CRH-R1, CRH-R-1, CRHR1L

Human Chr (Location): 17q21.31; chr17:45784280-45835828 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.
 
Interactions
Crhr1 interacts with 114 markers (Mir17, Mir18, Mir18b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (6)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CRHR1 ; Xenbase crhr1, crhr1.1 ; ZFIN crhr1    NEW 
Molecular
reagents
All nucleic(27) Genomic(3) cDNA(15) Primer pair(9)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003151 (Evidence)
Ensembl Gene Model ENSMUSG00000018634 (Evidence)
Entrez Gene 12921 (Evidence)
UniGene 1892
DFCI TC1584687
DoTS DT.40180294, DT.97411300
NIA Mouse Gene Index U013427
Consensus CDS Project CCDS25526.1
International Mouse Phenotyping Consortium Status Crhr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003151 VEGA Gene Model | MGI Sequence Detail 42669 C57BL/6J ±  kb
transcript OTTMUST00000006508 VEGA | MGI Sequence Detail 2460 Not Applicable 
polypeptide OTTMUSP00000003077 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(501 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003051 GPCR, family 2, corticotropin releasing factor receptor
InterPro IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000005869 corticotropin-releasing factor receptor 1
References
(Earliest) J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
(Latest) J:219875 Justice NJ, et al., Posttraumatic stress disorder-like induction elevates beta-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015 Feb 11;35(6):2612-23
All references(113)
Other
accession IDs
MGD-MRK-2141

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory