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Crhr1 Gene Detail
Summary
  • Symbol
    Crhr1
  • Name
    corticotropin releasing hormone receptor 1
  • Synonyms
    CRF1R, CRF 1 receptor, CRFR1, CRF-R1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:88498
    NCBI Gene: 12921
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:104023681-104066349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 67.77 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3010 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88498
 protein coding gene Chr11:104021289-104066349 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019272
 protein coding gene Chr11:107270612-107315019 (+)
A/J MGP_AJ_G0019240
 protein coding gene Chr11:102706769-102750519 (+)
AKR/J MGP_AKRJ_G0019209
 protein coding gene Chr11:105850681-105893756 (+)
BALB/cJ MGP_BALBcJ_G0019214
 protein coding gene Chr11:103140487-103183808 (+)
C3H/HeJ MGP_C3HHeJ_G0019023
 protein coding gene Chr11:106084790-106127376 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019664
 protein coding gene Chr11:110574808-110624993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017289
 protein coding gene Chr11:100110584-100153697 (+)
CAST/EiJ MGP_CASTEiJ_G0018577
 protein coding gene Chr11:107121778-107167205 (+)
CBA/J MGP_CBAJ_G0018992
 protein coding gene Chr11:115174988-115219304 (+)
DBA/2J MGP_DBA2J_G0019104
 protein coding gene Chr11:102196092-102239046 (+)
FVB/NJ MGP_FVBNJ_G0019095
 protein coding gene Chr11:101727083-101773747 (+)
LP/J MGP_LPJ_G0019173
 protein coding gene Chr11:107740010-107786059 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019125
 protein coding gene Chr11:114502726-114545400 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019701
 protein coding gene Chr11:106244977-106289272 (+)
PWK/PhJ MGP_PWKPhJ_G0018341
 protein coding gene Chr11:103288010-103331453 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018132
 protein coding gene Chr11:106003096-106049701 (+)
WSB/EiJ MGP_WSBEiJ_G0018626
 protein coding gene Chr11:106246160-106291980 (+)



Homology
more
  • Human Ortholog
    CRHR1, corticotropin releasing hormone receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRHR1, corticotropin releasing hormone receptor 1
  • Synonyms
    CRF1, CRF-R, CRF-R-1, CRF-R1, CRFR-1, CRFR1, CRHR, CRH-R-1, CRH-R1, CRHR1L
  • Links
    NCBI Gene ID: 1394
    UniProt: P34998

  • Chr Location
    17q21.31; chr17:45784277-45835828 (+)  GRCh38
  • Human Ortholog
    LINC02210-CRHR1, LINC02210-CRHR1 readthrough
  • Synonyms
    CRHR1-IT1-CRHR1, MGC57346-CRHR1
  • Links
    NCBI Gene ID: 104909134

  • Chr Location
    17q21.31; chr17:45620344-45835828 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CRHR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 8 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    30
  • cDNA Data
    16
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018634 Ensembl Gene Model | MGI Sequence Detail 42669 C57BL/6J ±  kb
    transcript ENSMUST00000093925 Ensembl | MGI Sequence Detail 2460 Not Applicable  
    polypeptide ENSMUSP00000091455 Ensembl | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005869 corticotropin-releasing factor receptor 1
      (term hierarchy)
    • InterPro Domains
      IPR003051 GPCR, family 2, corticotropin releasing factor receptor
      IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      P35347 5 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 3
      cDNA 17
      Primer pair 11
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2141
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 13
      Gene Ontology 15
      Phenotypes 92
    • Earliest
      J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
    • Latest
      J:364216 Piccin A, et al., Disruption of the CRF(1) receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice. Elife. 2025 Feb 5;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory