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Crhr1
Gene Detail
Symbol

Name
ID
Crhr1
corticotropin releasing hormone receptor 1
MGI:88498
Synonyms
CRF 1 receptor, CRFR1, CRF-R1alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 11
67.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:104132855-104175523 bp, + strand
From VEGA annotation of GRCm38

  42669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Crhr1

Human
homologs
Human Homolog CRHR1, corticotropin releasing hormone receptor 1
NCBI Gene ID 1394
neXtProt AC  NX_P34998
Human Synonyms  CRF1, CRF-R, CRFR1, CRF-R1, CRF-R-1, CRFR-1, CRHR, CRH-R1, CRH-R-1, CRHR1f, CRH-R1h, CRHR1L
Human Chr (Location)  17q12-q22; chr17:45620344-45835828 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.
 
Interactions
Crhr1 interacts with 115 markers (Mir17, Mir18, Mir18b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (6)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(3) cDNA(15) Primer pair(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003151 (Evidence)
Ensembl Gene ModelENSMUSG00000018634 (Evidence)
Entrez Gene12921 (Evidence)
UniGene1892
DFCITC1584687
DoTSDT.40180294, DT.97411300
NIA Mouse Gene IndexU013427
Consensus CDS ProjectCCDS25526.1
International Mouse Knockout Project StatusCrhr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003151 VEGA Gene Model | MGI Sequence Detail 42669 C57BL/6J ±  kb
transcript OTTMUST00000006508 VEGA | MGI Sequence Detail 2460 Not Applicable 
polypeptide OTTMUSP00000003077 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(501 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003051 GPCR, family 2, corticotropin releasing factor receptor
InterPro IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000005869 corticotropin-releasing factor receptor 1
References
(Earliest) J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
(Latest) J:214133 Nantie LB, et al., Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification. Mol Endocrinol. 2014 May;28(5):731-44
All references(113)
Other
accession IDs
MGD-MRK-2141

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory