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Crhr1 Gene Detail
Summary
  • Symbol
    Crhr1
  • Name
    corticotropin releasing hormone receptor 1
  • Synonyms
    CRF1R, CRF 1 receptor, CRFR1, CRF-R1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:88498
    NCBI Gene: 12921
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:104132855-104175523 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42669 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.77 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    CRHR1, corticotropin releasing hormone receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRHR1, corticotropin releasing hormone receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRF1, CRF-R, CRFR1, CRF-R1, CRF-R-1, CRFR-1, CRHR, CRH-R1, CRH-R-1, CRHR1L
  • Links
    NCBI Gene ID: 1394
    neXtProt AC: NX_P34998
    UniProt: P34998

  • Chr Location
    17q21.31; chr17:45784280-45835828 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 8 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003151 VEGA Gene Model | MGI Sequence Detail 42669 C57BL/6J ±  kb
    transcript OTTMUST00000006508 VEGA | MGI Sequence Detail 2460 Not Applicable  
    polypeptide OTTMUSP00000003077 VEGA | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      502 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005869 corticotropin-releasing factor receptor 1
    • InterPro Domains
      IPR003051 GPCR, family 2, corticotropin releasing factor receptor
      IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 3
      cDNA 15
      Primer pair 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2141
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 70
    • Earliest
      J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
    • Latest
      J:258273 McClard CK, et al., POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. J Neurosci. 2018 Feb 7;38(6):1443-1461

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory