Crhr1
Gene Detail

Symbol Name ID

Crhr1 corticotropin releasing hormone receptor 1 MGI:88498

Synonyms

CRF 1 receptor, CRFR1, CRF-R1alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr11:104132855-104175523 bp, + strand From VEGA annotation of GRCm38   42669 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Crhr1

Human homologs

Human Homolog		CRHR1, corticotropin releasing hormone receptor 1
NCBI Gene ID		1394
neXtProt AC		NX_P34998
Human Synonyms		CRF1, CRF-R, CRFR1, CRF-R1, CRF-R-1, CRFR-1, CRHR, CRH-R1, CRH-R-1, CRHR1f, CRH-R1h, CRHR1L
Human Chr (Location)		17q12-q22; chr17:43697710-43913194 (+)  GRCh37.p13

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	apical part of cell, cell, ...
Function	corticotrophin-releasing factor receptor activity, corticotropin-releasing hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 17, 28

Assay Type	Results
RT-PCR	6

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(3) cDNA(15) Primer pair(9)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003151 (Evidence)
Ensembl Gene Model	ENSMUSG00000018634 (Evidence)
Entrez Gene	12921 (Evidence)
UniGene	1892
DFCI	TC1584687
DoTS	DT.40180294, DT.97411300
NIA Mouse Gene Index	U013427
Consensus CDS Project	CCDS25526.1
International Mouse Knockout Project Status	Crhr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003151	VEGA Gene Model | MGI Sequence Detail	42669	C57BL/6J
transcript	OTTMUST00000006508	VEGA | MGI Sequence Detail	2460	Not Applicable
polypeptide	OTTMUSP00000003077	VEGA | MGI Sequence Detail	415	Not Applicable

All sequences(39) RefSeq(8) UniProt(6)

Polymorphisms

RFLP(1) : SNPs within 2kb(501 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003051	GPCR, family 2, corticotropin releasing factor receptor
InterPro	IPR003052	GPCR, family 2, corticotropin releasing factor receptor, type 1
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000005869	corticotropin-releasing factor receptor 1

References

(Earliest) J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
(Latest) J:203358 Wang XD, et al., Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nat Neurosci. 2013 Jun;16(6):706-13
All references(110)

Other accession IDs

MGD-MRK-2141