Crhr1 MGI Mouse Gene Detail - MGI:88498 - corticotropin releasing hormone receptor 1

Symbol

Crhr1
Name

corticotropin releasing hormone receptor 1
Synonyms

CRF1R, CRF 1 receptor, CRFR1, CRF-R1alpha

Feature Type

protein coding gene
IDs

MGI:88498
NCBI Gene: 12921
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:104132855-104175523 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.77 cM
Mapping Data

10 experiments

SNPs within 2kb

502 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88498	protein coding gene	Chr11:104130463-104175523 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019272	protein coding gene	Chr11:107270612-107315019 (+)
A/J	MGP_AJ_G0019240	protein coding gene	Chr11:102706769-102750519 (+)
AKR/J	MGP_AKRJ_G0019209	protein coding gene	Chr11:105850681-105893756 (+)
BALB/cJ	MGP_BALBcJ_G0019214	protein coding gene	Chr11:103140487-103183808 (+)
C3H/HeJ	MGP_C3HHeJ_G0019023	protein coding gene	Chr11:106084790-106127376 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019664	protein coding gene	Chr11:110574808-110624993 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017289	protein coding gene	Chr11:100110584-100153697 (+)
CAST/EiJ	MGP_CASTEiJ_G0018577	protein coding gene	Chr11:107121778-107167205 (+)
CBA/J	MGP_CBAJ_G0018992	protein coding gene	Chr11:115174988-115219304 (+)
DBA/2J	MGP_DBA2J_G0019104	protein coding gene	Chr11:102196092-102239046 (+)
FVB/NJ	MGP_FVBNJ_G0019095	protein coding gene	Chr11:101727083-101773747 (+)
LP/J	MGP_LPJ_G0019173	protein coding gene	Chr11:107740010-107786059 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019125	protein coding gene	Chr11:114502726-114545400 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019701	protein coding gene	Chr11:106244977-106289272 (+)
PWK/PhJ	MGP_PWKPhJ_G0018341	protein coding gene	Chr11:103288010-103331453 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018132	protein coding gene	Chr11:106003096-106049701 (+)
WSB/EiJ	MGP_WSBEiJ_G0018626	protein coding gene	Chr11:106246160-106291980 (+)

Human Ortholog

CRHR1, corticotropin releasing hormone receptor 1

Vertebrate Orthologs

10

Human Ortholog

CRHR1, corticotropin releasing hormone receptor 1
Orthology source: HomoloGene, HGNC
Synonyms

CRF1, CRF-R, CRFR1, CRF-R1, CRF-R-1, CRFR-1, CRHR, CRH-R1, CRH-R-1, CRHR1L
Links

HGNC:2357

NCBI Gene ID: 1394

neXtProt AC: NX_P34998

UniProt: P34998
Chr Location

17q21.31; chr17:45784280-45835828 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20920
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CRHR1
Protein SuperFamily

G protein-coupled receptor, peptide hormone receptor type
Gene Tree

Crhr1

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Phenotype Summary

31 phenotypes from 8 alleles in 10 genetic backgrounds
5 phenotypes from multigenic genotypes
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Targeted

16
Genomic Mutations

1 involving Crhr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

1

Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth.

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All GO Annotations

69
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

678
Tissues

18
cDNA Data

15
Literature Summary

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CRHR1

Xenbase crhr1.1, crhr1.2

ZFIN crhr1

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Crhr1 interacts with 114 markers (Mir17, Mir18, Mir18b, ...) View All

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All Sequences

61
RefSeq

15
UniProt

6
CCDS

CCDS25526.1
UniGene

1892

Ensembl

ENSMUSG00000018634 (Evidence)
NCBI Gene

12921

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018634	Ensembl Gene Model \| MGI Sequence Detail	42669	C57BL/6J	± kb
transcript	ENSMUST00000093925	Ensembl \| MGI Sequence Detail	2460	Not Applicable
polypeptide	ENSMUSP00000091455	Ensembl \| MGI Sequence Detail	415	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005869 corticotropin-releasing factor receptor 1

(term hierarchy)
InterPro Domains

IPR003051 GPCR, family 2, corticotropin releasing factor receptor

IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR017981 GPCR, family 2-like

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

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All nucleic 30

Genomic 3

cDNA 16

Primer pair 9

Other 2

Microarray probesets 4

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MGD-MRK-2141

Summaries

All 155

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 77
Earliest

J:15698 Vita N, et al., Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993 Nov 29;335(1):1-5
Latest

J:286755 Hu P, et al., Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. J Neurosci. 2020 Mar 18;40(12):2519-2537

TSS for Crhr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105367	Chr11:104132810-104132828 (+)	-36 bp
Tssr105368	Chr11:104132832-104132839 (+)	-19 bp
Tssr105369	Chr11:104132841-104132852 (+)	-8 bp
Tssr105370	Chr11:104132864-104132876 (+)	15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16