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Col1a2
Gene Detail
Symbol

Name
ID
Col1a2
collagen, type I, alpha 2
MGI:88468
STS
Synonyms
Col1a-2, Cola2, Cola-2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
1.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr6:4504814-4541543 bp, + strand
From VEGA annotation of GRCm38

  36730 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Col1a2

Human
homologs
Human Homolog COL1A2, collagen, type I, alpha 2
NCBI Gene ID 1278
neXtProt AC  NX_P08123
Human Synonyms  OI4
Human Chr (Location)  7q22.1; chr7:94394561-94431232 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human COL1A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation in this gene exhibit reduced body size, reduced bone density and cortical bone thickness, fractured and deformed long bones, dorsal kyphosis, and droopy wrists. Older mutants develop an abnormal gait.
 
Human Diseases Modeled Using Mouse Col1a2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Col1a2 interacts with 231 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (110 records)
Data Summary: Results (224)    Tissues (107)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 67
RNA in situ 125
Northern blot 2
Western blot 16
RT-PCR 14
cDNA source data(1265)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1284) Genomic(5) cDNA(1271) Primer pair(4) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021300 (Evidence)
Ensembl Gene ModelENSMUSG00000029661 (Evidence)
Entrez Gene12843 (Evidence)
UniGene277792
DFCITC1573649, TC1647216, TC1710402, TC1717068
DoTSDT.101147361, DT.101157189, DT.101178459, DT.101399378, DT.101399406, DT.101715384, DT.91340938, DT.91360272, DT.94311443
NIA Mouse Gene IndexU006505
Consensus CDS ProjectCCDS39420.1
International Mouse Knockout Project StatusCol1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021300 VEGA Gene Model | MGI Sequence Detail 36730 C57BL/6J ±  kb
transcript OTTMUST00000050501 VEGA | MGI Sequence Detail 5347 Not Applicable 
polypeptide OTTMUSP00000023584 VEGA | MGI Sequence Detail 1372 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(2) UniProt(13)
Polymorphisms
RFLP(4) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR000885 Fibrillar collagen, C-terminal
Protein Ontology PR:000003265 collagen alpha-2(I) chain
References
(Earliest) J:7086 Shupp Byrne DE, et al., Assignment of the genes for mouse type I procollagen to chromosome 16 using mouse fibroblast-Chinese hamster somatic cell hybrids. Somatic Cell Genet. 1983 May;9(3):313-31
(Latest) J:214984 Gonzalez-Martin MC, et al., Long bone development requires a threshold of Hox function. Dev Biol. 2014 Aug 15;392(2):454-65
All references(245)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13027, MGD-MRK-2060, MGD-MRK-2088, MGD-MRK-2090, MGI:2141374, MGI:2141395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory