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Col4a2
Gene Detail
Symbol

Name
ID
Col4a2
collagen, type IV, alpha 2
MGI:88455
Synonyms
Col4a-2, MGC:7371
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:11312805-11449287 bp, + strand
From VEGA annotation of GRCm38

  136483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Col4a2

Human
homologs
Human Homolog COL4A2, collagen, type IV, alpha 2
NCBI Gene ID 1284
neXtProt AC  NX_P08572
Human Synonyms  ICH, POREN2
Human Chr (Location)  13q34; chr13:110307284-110513027 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human COL4A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(3) Gene trapped(6) Targeted(1)
Genomic Mutations involving Col4a2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
ENU-induced missense mutations of this gene result in a variable phenotype affecting the eye, brain and vascular stability in heterozygotes, and fetal or postnatal survival in homozygotes.
 
Interactions
Col4a2 interacts with 168 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process angiogenesis, negative regulation of angiogenesis, ...
Component basement membrane, collagen trimer, ...
Function extracellular matrix structural constituent
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (61)    Tissues (43)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 40
RT-PCR 10
cDNA source data(302)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(313) Genomic(5) cDNA(305) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021317 (Evidence)
Ensembl Gene ModelENSMUSG00000031503 (Evidence)
Entrez Gene12827 (Evidence)
UniGene181021
DFCITC1572144, TC1639251
DoTSDT.101162742, DT.101373434, DT.101402395, DT.40134383, DT.94359644, DT.94359661
NIA Mouse Gene IndexU009073
Consensus CDS ProjectCCDS40220.1
International Mouse Knockout Project StatusCol4a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021317 VEGA Gene Model | MGI Sequence Detail 136483 C57BL/6J ±  kb
transcript OTTMUST00000050538 VEGA | MGI Sequence Detail 6450 Not Applicable 
polypeptide OTTMUSP00000023606 VEGA | MGI Sequence Detail 1707 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(1398 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001442 Collagen IV, non-collagenous
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR016187 C-type lectin fold
Protein Ontology PR:000005714 collagen alpha-2(IV) chain
References
(Earliest) J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
(Latest) J:213088 Soteriou D, et al., Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J Biol Chem. 2013 Jun 28;288(26):18716-31
All references(87)
Other
accession IDs
MGD-MRK-2067, MGD-MRK-2069, MGI:2142691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory