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Vsx2
Gene Detail
Symbol

Name
ID
Vsx2
visual system homeobox 2
MGI:88401
Synonyms
Chx10, Hox10, Hox-10
Feature Type
protein coding gene
Genetic Map
Chromosome 12
39.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr12:84569762-84595457 bp, + strand
From VEGA annotation of GRCm38

  25696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vsx2

Human
homologs
Human Homolog VSX2, visual system homeobox 2
NCBI Gene ID 338917
neXtProt AC  NX_P58304
Human Synonyms  CHX10, HOX10, MCOP2, MCOPCB3, RET1
Human Chr (Location)  14q24.3; chr14:74239472-74262738 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human VSX2
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Spontaneous(3) Targeted(9)
 
Homozygotes for spontaneous mutations exhibit microphthalmia, lack of retinal intercellular channels, and agenesis of the optic nerve. Homozygotes for one mutant allele also have a germ cell maturation defect with sterility in both sexes.
 
Phenotype Images(8)
Interactions
Vsx2 interacts with 188 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process camera-type eye development, cell fate commitment, ...
Component cytoplasm, intracellular, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (217 records)
Data Summary: Results (247)    Tissues (144)    Images (92)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 196
Northern blot 16
Western blot 4
cDNA source data(46)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(4) cDNA(48) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000038498 (Evidence)
Ensembl Gene ModelENSMUSG00000021239 (Evidence)
Entrez Gene12677 (Evidence)
UniGene4405
DFCITC1581773, TC1589312
DoTSDT.94279276, DT.97393378
NIA Mouse Gene IndexU014197
Consensus CDS ProjectCCDS36493.1
International Mouse Knockout Project StatusVsx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038498 VEGA Gene Model | MGI Sequence Detail 25696 C57BL/6J ±  kb
transcript OTTMUST00000099372 VEGA | MGI Sequence Detail 3249 Not Applicable 
polypeptide OTTMUSP00000055786 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023339 CVC domain
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000017355 visual system homeobox 2
References
(Earliest) J:307 TRUSLOVE GM, A gene causing ocular retardation in the mouse. J Embryol Exp Morphol. 1962 Dec;10:652-60
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(284)
Other
accession IDs
MGD-MRK-10826, MGD-MRK-13044, MGD-MRK-1983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory