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Vsx2 Gene Detail
Summary
  • Symbol
    Vsx2
  • Name
    visual system homeobox 2
  • Synonyms
    Chx10, Hox10, Hox-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:88401
    NCBI Gene: 12677
  • Gene Overview
    MyGene.info: VSX2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84569828-84595457 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.28 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88401
protein coding gene Chr12:84569762-84595457 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019940
protein coding gene Chr12:85291734-85317422 (+)
A/J MGP_AJ_G0019897
protein coding gene Chr12:82061021-82087985 (+)
AKR/J MGP_AKRJ_G0019873
protein coding gene Chr12:84278503-84304035 (+)
BALB/cJ MGP_BALBcJ_G0019877
protein coding gene Chr12:82394145-82419752 (+)
C3H/HeJ MGP_C3HHeJ_G0019683
protein coding gene Chr12:84749200-84775775 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020328
protein coding gene Chr12:87749013-87776513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017946
protein coding gene Chr12:78956989-78983082 (+)
CAST/EiJ MGP_CASTEiJ_G0019232
protein coding gene Chr12:79703529-79731436 (+)
CBA/J MGP_CBAJ_G0019654
protein coding gene Chr12:91137829-91169205 (+)
DBA/2J MGP_DBA2J_G0019769
protein coding gene Chr12:81585784-81611199 (+)
FVB/NJ MGP_FVBNJ_G0019755
protein coding gene Chr12:80542795-80569551 (+)
LP/J MGP_LPJ_G0019841
protein coding gene Chr12:85168867-85197781 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019794
protein coding gene Chr12:94039198-94066257 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020362
protein coding gene Chr12:83885981-83912698 (+)
PWK/PhJ MGP_PWKPhJ_G0018996
protein coding gene Chr12:76074922-76101740 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018791
protein coding gene Chr12:78374479-78400725 (+)
WSB/EiJ MGP_WSBEiJ_G0019284
protein coding gene Chr12:84590169-84616837 (+)



Homology
more
  • Human Ortholog
    VSX2, visual system homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VSX2, visual system homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHX10, HOX10, MCOP2, MCOPCB3, RET1
  • Links
    NCBI Gene ID: 338917
    neXtProt AC: NX_P58304
    UniProt: P58304

  • Chr Location
    14q24.3; chr14:74239472-74262738 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7266
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VSX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 6 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    8 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous mutations exhibit microphthalmia, lack of retinal intercellular channels, and agenesis of the optic nerve. Homozygotes for one mutant allele also have a germ cell maturation defect with sterility in both sexes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12677 NCBI Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
    transcript NM_001301427 RefSeq | MGI Sequence Detail 3276 C57BL/6  
    polypeptide Q61412 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 4
      cDNA 50
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10826, MGD-MRK-13044, MGD-MRK-1983
    References
    more
    • Summaries
      All 365
      Developmental Gene Expression 292
      Gene Ontology 10
      Phenotypes 55
    • Earliest
      J:307 TRUSLOVE GM, A gene causing ocular retardation in the mouse. J Embryol Exp Morphol. 1962 Dec;10:652-60
    • Latest
      J:266268 Kowalchuk AM, et al., Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol. 2018 Oct 15;442(2):220-235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory