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Vsx2
Gene Detail
Symbol

Name
ID
Vsx2
visual system homeobox 2
MGI:88401
Synonyms
Chx10, Hox10, Hox-10
Feature Type
protein coding gene
Genetic Map
Chromosome 12
39.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr12:84569762-84595457 bp, + strand
From VEGA annotation of GRCm38

  25696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VSX2
Gene Tree: Vsx2

Human
homologs
VSX2, visual system homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 338917
neXtProt AC: NX_P58304

Human Synonyms: CHX10, HOX10, MCOP2, MCOPCB3, RET1

Human Chr (Location): 14q24.3; chr14:74239472-74262738 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human VSX2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Spontaneous(3) Targeted(9)
Incidental mutations (data from CvDC )
 
Homozygotes for spontaneous mutations exhibit microphthalmia, lack of retinal intercellular channels, and agenesis of the optic nerve. Homozygotes for one mutant allele also have a germ cell maturation defect with sterility in both sexes.
 
Phenotype Images(8)
Interactions
Vsx2 interacts with 188 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process camera-type eye development, cell fate commitment, ...
Component cytoplasm, intracellular, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (229 records)
Data Summary: Results (249)    Tissues (146)    Images (92)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 33
RNA in situ 196
Northern blot 16
Western blot 4
cDNA source data(46)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA VSX2 ; Xenbase vsx2 ; ZFIN vsx2    NEW 
Molecular
reagents
All nucleic(55) Genomic(4) cDNA(48) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000038498 (Evidence)
Ensembl Gene Model ENSMUSG00000021239 (Evidence)
Entrez Gene 12677 (Evidence)
UniGene 4405
DFCI TC1581773, TC1589312
DoTS DT.94279276, DT.97393378
NIA Mouse Gene Index U014197
Consensus CDS Project CCDS36493.1
International Mouse Phenotyping Consortium Status Vsx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038498 VEGA Gene Model | MGI Sequence Detail 25696 C57BL/6J ±  kb
transcript OTTMUST00000099372 VEGA | MGI Sequence Detail 3249 Not Applicable 
polypeptide OTTMUSP00000055786 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023339 CVC domain
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000017355 visual system homeobox 2
References
(Earliest) J:307 TRUSLOVE GM, A gene causing ocular retardation in the mouse. J Embryol Exp Morphol. 1962 Dec;10:652-60
(Latest) J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
All references(295)
Other
accession IDs
MGD-MRK-10826, MGD-MRK-13044, MGD-MRK-1983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory