Vsx2
Gene Detail

Symbol Name ID

Vsx2 visual system homeobox 2 MGI:88401

Synonyms

Chx10, Hox10, Hox-10

Feature Type

protein coding gene

Genetic Map

Chromosome 12

39.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr12:84569762-84595461 bp, + strand From VEGA annotation of GRCm38   25700 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Vsx2

Human homologs

Human Homolog		VSX2, visual system homeobox 2
NCBI Gene ID		338917
neXtProt AC		NX_P58304
Human Synonyms		CHX10, HOX10, MCOP2, MCOPCB3, RET1
Human Chr (Location)		14q24.3; chr14:74706175-74729441 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human VSX2

Alleles and phenotypes

All alleles(12) : Targeted(9) Spontaneous(3)
 

Homozygotes for spontaneous mutations exhibit microphthalmia, lack of retinal intercellular channels, and agenesis of the optic nerve. Homozygotes for one mutant allele also have a germ cell maturation defect with sterility in both sexes.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	camera-type eye development, cell fate commitment, ...
Component	cytoplasm, intracellular, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (189 records)
Data Summary: Results (241)    Tissues (130)    Images (86)
Theiler Stages: 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	194
Northern blot	16
Western blot	4

cDNA source data(46)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(54) Genomic(4) cDNA(48) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000038498 (Evidence)
Ensembl Gene Model	ENSMUSG00000021239 (Evidence)
Entrez Gene	12677 (Evidence)
UniGene	4405
DFCI	TC1581773, TC1589312
DoTS	DT.94279276, DT.97393378
NIA Mouse Gene Index	U014197
Consensus CDS Project	CCDS36493.1
International Mouse Knockout Project Status	Vsx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038498	VEGA Gene Model | MGI Sequence Detail	25700	C57BL/6J
transcript	OTTMUST00000099372	VEGA | MGI Sequence Detail	3253	Not Applicable
polypeptide	OTTMUSP00000055786	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(29) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023339	CVC domain
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000017355	visual system homeobox 2

References

(Earliest) J:307 TRUSLOVE GM, A gene causing ocular retardation in the mouse. J Embryol Exp Morphol. 1962 Dec;10:652-60
(Latest) J:193399 Park S, et al., GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science. 2013 Jan 18;339(6117):324-8
All references(257)

Other accession IDs

MGD-MRK-10826, MGD-MRK-13044, MGD-MRK-1983