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Chrm3
Gene Detail
Symbol

Name
ID
Chrm3
cholinergic receptor, muscarinic 3, cardiac
MGI:88398
Synonyms
Chrm-3, M3R, muscarinic acetylcholine receptor 3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
3.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:9875486-10360844 bp, - strand
From VEGA annotation of GRCm38

  485359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm3

Human
homologs
Human Homolog CHRM3, cholinergic receptor, muscarinic 3
NCBI Gene ID 1131
neXtProt AC  NX_P20309
Human Synonyms  EGBRS, HM3
Human Chr (Location)  1q43; chr1:239386576-239915450 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHRM3
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.
 
Human Diseases Modeled Using Mouse Chrm3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Chrm3 interacts with 17 markers (Mir93, Mir101a, Mir101b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process digestion, G-protein coupled acetylcholine receptor signaling pathway, ...
Component asymmetric synapse, axon terminus, ...
Function acetylcholine binding, acetylcholine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (168)    Tissues (144)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 160
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000048429 (Evidence)
Ensembl Gene ModelENSMUSG00000046159 (Evidence)
Entrez Gene12671 (Evidence)
UniGene342315
DFCITC1587251
DoTSDT.60103920, DT.91435413
NIA Mouse Gene IndexU103368
Consensus CDS ProjectCCDS26238.1
International Mouse Knockout Project StatusChrm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048429 VEGA Gene Model | MGI Sequence Detail 485359 C57BL/6J ±  kb
transcript OTTMUST00000124140 VEGA | MGI Sequence Detail 4336 Not Applicable 
polypeptide OTTMUSP00000067594 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(4772 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000995 Muscarinic acetylcholine receptor family
InterPro IPR001183 Muscarinic acetylcholine receptor M3
Protein Ontology PR:000001615 muscarinic acetylcholine receptor M3
References
(Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:214125 Chen SR, et al., Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem. 2014 May 16;289(20):14321-30
All references(105)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1976, MGD-MRK-1980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory