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Chrm3
Gene Detail
 Symbol
Name
ID
Chrm3
cholinergic receptor, muscarinic 3, cardiac
MGI:88398
Synonyms Chrm-3, M3R, muscarinic acetylcholine receptor 3
Feature Type protein coding gene
Genetic Map
Chromosome 13
3.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:9877229-9878998 bp, - strand
From Ensembl annotation of GRCm38

  1770 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm3

Human
homologs
Human Homolog CHRM3, cholinergic receptor, muscarinic 3
NCBI Gene ID 1131
neXtProt AC  NX_P20309
Human Synonyms  EGBRS, HM3
Human Chr (Location)  1q43; chr1:239386576-239915450 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHRM3
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.
 
Human Diseases Modeled Using Mouse Chrm3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process digestion, G-protein coupled acetylcholine receptor signaling pathway, ...
Component asymmetric synapse, axon terminus, ...
Function acetylcholine binding, acetylcholine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (168)    Tissues (144)    Images (27)
Theiler Stages: 19, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 160
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000046159 (Evidence)
Entrez Gene12671 (Evidence)
UniGene342315
DFCITC1587251
DoTSDT.60103920, DT.91435413
NIA Mouse Gene IndexU103368
Consensus CDS ProjectCCDS26238.1
International Mouse Knockout Project StatusChrm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046159 Ensembl Gene Model | MGI Sequence Detail 1770 C57BL/6J ±  kb
transcript ENSMUST00000063093 Ensembl | MGI Sequence Detail 1770 Not Applicable 
polypeptide ENSMUSP00000055579 Ensembl | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(4762 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000995 Muscarinic acetylcholine receptor family
InterPro IPR001183 Muscarinic acetylcholine receptor M3
Protein Ontology PR:000001615 muscarinic acetylcholine receptor M3
References (Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:198712 Rinaldo L, et al., Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11181-6
All references(101)
Other
accession IDs
MGD-MRK-1976, MGD-MRK-1980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory