Chrm3
Gene Detail

Symbol Name ID

Chrm3 cholinergic receptor, muscarinic 3, cardiac MGI:88398

Synonyms

Chrm-3, M3R, muscarinic acetylcholine receptor 3

Feature Type

protein coding gene

Genetic Map

Chromosome 13

3.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:9877229-9878998 bp, - strand From Ensembl annotation of GRCm38   1770 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm3

Human homologs

Human Homolog		CHRM3, cholinergic receptor, muscarinic 3
NCBI Gene ID		1131
neXtProt AC		NX_P20309
Human Synonyms		EGBRS, HM3
Human Chr (Location)		1q43; chr1:239792373-240072720 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHRM3

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.

 
Human Diseases Modeled Using Mouse Chrm3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	digestion, G-protein coupled acetylcholine receptor signaling pathway, ...
Component	asymmetric synapse, axon terminus, ...
Function	acetylcholine binding, acetylcholine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (168)    Tissues (144)    Images (27)
Theiler Stages: 19, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	160

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000046159 (Evidence)
Entrez Gene	12671 (Evidence)
UniGene	342315
DFCI	TC1587251
DoTS	DT.60103920, DT.91435413
NIA Mouse Gene Index	U103368
Consensus CDS Project	CCDS26238.1
International Mouse Knockout Project Status	Chrm3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000046159	Ensembl Gene Model | MGI Sequence Detail	1770	C57BL/6J
transcript	ENSMUST00000063093	Ensembl | MGI Sequence Detail	1770	Not Applicable
polypeptide	ENSMUSP00000055579	Ensembl | MGI Sequence Detail	589	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(2143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000995	Muscarinic acetylcholine receptor
InterPro	IPR001183	Muscarinic acetylcholine receptor M3
Protein Ontology	PR:000001615	muscarinic acetylcholine receptor M3

References

(Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:195073 Arteaga-Solis E, et al., Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013 Jan 8;17(1):35-48
All references(100)

Other accession IDs

MGD-MRK-1976, MGD-MRK-1980