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Chrm3 Gene Detail
Summary
  • Symbol
    Chrm3
  • Name
    cholinergic receptor, muscarinic 3, cardiac
  • Synonyms
    Chrm-3, M3R, muscarinic acetylcholine receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88398
    NCBI Gene: 12671
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:9875486-10360847 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 3.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4758 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88398
protein coding gene Chr13:9875486-10360914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020226
protein coding gene Chr13:6528200-7037780 (-)
A/J MGP_AJ_G0020182
protein coding gene Chr13:6498104-6983666 (-)
AKR/J MGP_AKRJ_G0020157
protein coding gene Chr13:6600569-7105732 (-)
BALB/cJ MGP_BALBcJ_G0020165
protein coding gene Chr13:6488317-6984247 (-)
C3H/HeJ MGP_C3HHeJ_G0019969
protein coding gene Chr13:6719474-7251635 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020612
protein coding gene Chr13:6891857-7417134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018219
protein coding gene Chr13:6406595-6874464 (-)
CAST/EiJ MGP_CASTEiJ_G0019507
protein coding gene Chr13:6406114-6917241 (-)
CBA/J MGP_CBAJ_G0019936
protein coding gene Chr13:7060969-7633520 (-)
DBA/2J MGP_DBA2J_G0020053
protein coding gene Chr13:6324888-6819120 (-)
FVB/NJ MGP_FVBNJ_G0020038
protein coding gene Chr13:6155595-6642096 (-)
LP/J MGP_LPJ_G0020127
protein coding gene Chr13:6632563-7127000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020074
protein coding gene Chr13:7352055-7898768 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020640
protein coding gene Chr13:6512470-7022921 (-)
PWK/PhJ MGP_PWKPhJ_G0019270
protein coding gene Chr13:6385269-6872019 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019077
protein coding gene Chr13:6482315-7015495 (-)
WSB/EiJ MGP_WSBEiJ_G0019567
protein coding gene Chr13:6444086-6957040 (-)



Homology
more
  • Human Ortholog
    CHRM3, cholinergic receptor muscarinic 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHRM3, cholinergic receptor muscarinic 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EGBRS, HM3, PBS
  • Links
    NCBI Gene ID: 1131
    neXtProt AC: NX_P20309
    UniProt: P20309

  • Chr Location
    1q43; chr1:239386565-239915450 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Chrm3 mouse models; 1 with human CHRM3 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 7 alleles in 11 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046159 Ensembl Gene Model | MGI Sequence Detail 485362 C57BL/6J ±  kb
    transcript ENSMUST00000187510 Ensembl | MGI Sequence Detail 4336 Not Applicable  
    polypeptide ENSMUSP00000140131 Ensembl | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1976, MGD-MRK-1980
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 9
      Phenotypes 88
    • Earliest
      J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
    • Latest
      J:265364 Bouabid S, et al., Cyclic AMP-producing chemogenetic activation of indirect pathway striatal projection neurons and the downstream effects on the globus pallidus and subthalamic nucleus in freely moving mice. J Neurochem. 2018 Jun;145(6):436-448

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory