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Chrm3 Gene Detail
Summary
  • Symbol
    Chrm3
  • Name
    cholinergic receptor, muscarinic 3, cardiac
  • Synonyms
    Chrm-3, M3R, muscarinic acetylcholine receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88398
    NCBI Gene: 12671
Location & Maps
more
  • Sequence Map
    Chr13:9875486-10360844 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      485359 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 3.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CHRM3, cholinergic receptor muscarinic 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHRM3, cholinergic receptor muscarinic 3
    Orthology source: HomoloGene
  • Synonyms
    EGBRS, HM3, PBS
  • Links
    NCBI Gene ID: 1131
    neXtProt AC: NX_P20309

  • Chr Location
    1q43; chr1:239386565-239911462 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Chrm3 mouse models; 1 with human CHRM3 associations

Human Disease Mouse Models
       Visceral Myopathy; VSCM   OMIM: 155310 View 1 model
       Prune Belly Syndrome; PBS   OMIM: 100100
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 6 alleles in 10 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    1
  • Targeted
    6
  • Transgenic
    3
  • Incidental Mutations
Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048429 VEGA Gene Model | MGI Sequence Detail 485359 C57BL/6J ±  kb
transcript OTTMUST00000124140 VEGA | MGI Sequence Detail 4336 Not Applicable  
polypeptide OTTMUSP00000067594 VEGA | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4758 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001615 muscarinic acetylcholine receptor M3
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000995 Muscarinic acetylcholine receptor family
    IPR001183 Muscarinic acetylcholine receptor M3
Molecular
Reagents
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  • All nucleic 14
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1976, MGD-MRK-1980
References
more
  • Summaries
    All 109
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 71
  • Earliest
    J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
  • Latest
    J:227801 Kistemaker LE, et al., Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L96-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory