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Chrm3
Gene Detail
Symbol

Name
ID
Chrm3
cholinergic receptor, muscarinic 3, cardiac
MGI:88398
Synonyms
Chrm-3, M3R, muscarinic acetylcholine receptor 3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
3.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:9875486-10360844 bp, - strand
From VEGA annotation of GRCm38

  485359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHRM3
Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm3

Human
homologs
CHRM3, cholinergic receptor, muscarinic 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1131
neXtProt AC: NX_P20309

Human Synonyms: EGBRS, HM3

Human Chr (Location): 1q43; chr1:239386565-239911462 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHRM3

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(6) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.
 
Human Diseases Modeled in Mice Using Chrm3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Chrm3 interacts with 17 markers (Mir93, Mir101a, Mir101b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (168)    Tissues (144)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 160
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048429 (Evidence)
Ensembl Gene Model ENSMUSG00000046159 (Evidence)
Entrez Gene 12671 (Evidence)
UniGene 342315
DFCI TC1587251
DoTS DT.60103920, DT.91435413
NIA Mouse Gene Index U103368
Consensus CDS Project CCDS26238.1
International Mouse Phenotyping Consortium Status Chrm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048429 VEGA Gene Model | MGI Sequence Detail 485359 C57BL/6J ±  kb
transcript OTTMUST00000124140 VEGA | MGI Sequence Detail 4336 Not Applicable 
polypeptide OTTMUSP00000067594 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(4772 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000995 Muscarinic acetylcholine receptor family
InterPro IPR001183 Muscarinic acetylcholine receptor M3
Protein Ontology PR:000001615 muscarinic acetylcholine receptor M3
References
(Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:215907 Zhao CM, et al., Denervation suppresses gastric tumorigenesis. Sci Transl Med. 2014 Aug 20;6(250):250ra115
All references(105)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1976, MGD-MRK-1980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory