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Chrm1
Gene Detail
 Symbol
Name
ID
Chrm1
cholinergic receptor, muscarinic 1, CNS
MGI:88396
Synonyms AW495047, Chrm-1, M1, M1R, muscarinic acetylcholine receptor 1
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8663789-8681567 bp, + strand
From VEGA annotation of GRCm38

  17779 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm1

Human
homologs
Human Homolog CHRM1, cholinergic receptor, muscarinic 1
NCBI Gene ID 1128
neXtProt AC  NX_P11229
Human Synonyms  HM1, M1, M1R
Human Chr (Location)  11q13; chr11:62908679-62921540 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit resistance to pilocarpine-induced seizures, selective memory deficits, elevated dopaminergic transmission in the striatum, and increased spontaneous and amphetamine-induced locomotion.
 
Interactions
Chrm1 interacts with 332 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cognition, G-protein coupled acetylcholine receptor signaling pathway, ...
Component asymmetric synapse, axon terminus, ...
Function drug binding, G-protein coupled acetylcholine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (77)    Tissues (48)    Images (15)
Theiler Stages: 19, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 77
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000039794 (Evidence)
Ensembl Gene ModelENSMUSG00000032773 (Evidence)
Entrez Gene12669 (Evidence)
UniGene240607
DFCITC1584476, TC1595412, TC1674221, TC1711843
DoTSDT.101372231, DT.87039748, DT.97410784
NIA Mouse Gene IndexU019119
Consensus CDS ProjectCCDS29539.1
International Mouse Knockout Project StatusChrm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039794 VEGA Gene Model | MGI Sequence Detail 17779 C57BL/6J ±  kb
transcript OTTMUST00000103445 VEGA | MGI Sequence Detail 4159 Not Applicable 
polypeptide OTTMUSP00000057800 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000995 Muscarinic acetylcholine receptor family
InterPro IPR002228 Muscarinic acetylcholine receptor M1
Protein Ontology PR:000001613 muscarinic acetylcholine receptor M1
References (Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:201202 Barathi VA, et al., Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice. Dis Model Mech. 2013 Sep-Oct;6(5):1146-58
All references(99)
Other
accession IDs
MGD-MRK-1974, MGD-MRK-1978, MGI:3528183

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory