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Gene Detail
 Symbol
Name
ID
Chat
choline acetyltransferase
MGI:88392
Synonyms B230380D24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
19.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:32408203-32465909 bp, - strand
From NCBI annotation of GRCm38

  57707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carnitine O-acetyltransferase
Gene Tree: Chat

Human
homologs
Human Homolog CHAT, choline O-acetyltransferase
NCBI Gene ID 1103
neXtProt AC  NX_P28329
Human Synonyms  CHOACTASE, CMS1A, CMS1A2
Human Chr (Location)  10q11.2; chr10:49609095-49665104 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in hyperinnervation of motor neurons, abnormal morphology and patterning of neuromuscular synapses, and perinatal lethality. Mutant fetuses at E18.5 exhibit a hunched position, reduced body length, and carpoptosis (drop wrist).
 
Interactions
Chat interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process acetylcholine biosynthetic process, adult walking behavior, ...
Component axon, mitochondrion, ...
Function choline binding, choline O-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (165 records)
Data Summary: Results (176)    Tissues (137)    Images (26)
Theiler Stages: 15, 17, 19, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 132
RT-PCR 27
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(8) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000021919 (Evidence)
Entrez Gene12647 (Evidence)
UniGene442817
DFCITC1588570, TC1657016
DoTSDT.101717706, DT.110772748, DT.110772757, DT.55165451, DT.55165514, DT.94174404, DT.94190894
EC2.3.1.6
Consensus CDS ProjectCCDS26920.1
International Mouse Knockout Project StatusChat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12647 NCBI Gene Model | MGI Sequence Detail 57707 C57BL/6J ±  kb
transcript NM_009891 RefSeq | MGI Sequence Detail 2810 C57BL/6 
polypeptide Q03059 UniProt | EBI | MGI Sequence Detail 641 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000542 Acyltransferase ChoActase/COT/CPT
Protein Ontology PR:000005404 choline O-acetyltransferase
Graphical View of Protein Domain Structure
References (Earliest) J:10493 Ishii K, et al., Complementary DNAs for choline acetyltransferase from spinal cords of rat and mouse: nucleotide sequences, expression in mammalian cells, and in situ hybridization. Brain Res Mol Brain Res. 1990 Feb;7(2):151-9
(Latest) J:210450 Rothermel M, et al., Cholinergic inputs from Basal forebrain add an excitatory bias to odor coding in the olfactory bulb. J Neurosci. 2014 Mar 26;34(13):4654-64
All references(258)
Other
accession IDs
MGD-MRK-1967, MGI:2443404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory