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F5
Gene Detail
 Symbol
Name
ID
F5
coagulation factor V
MGI:88382
Synonyms Cf5, Cf-5
Feature Type protein coding gene
Genetic Map
Chromosome 1
71.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:164151838-164220277 bp, + strand
From VEGA annotation of GRCm38

  68440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor V/coagulation factor VIII
Gene Tree: F5

Human
homologs
Human Homolog F5, coagulation factor V (proaccelerin, labile factor)
NCBI Gene ID 2153
neXtProt AC  NX_P12259
Human Synonyms  FVL, PCCF, RPRGL1, THPH2
Human Chr (Location)  1q23; chr1:169511954-169586531 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human F5
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Half of mice homozygous for a null allele die at E9-E10 with defects in yolk-sac vasculature and somite formation; the remaining half develop to term but die of massive hemorrhage within hours of birth. Mice homozygous for a knock-in (F5 Leiden) allele develop strain-specific perinatal thrombosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process blood circulation, blood coagulation, ...
Component endoplasmic reticulum, extracellular region, ...
Function copper ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (32)    Tissues (13)    Images (24)
Theiler Stages: 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 23
RT-PCR 9
cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) Genomic(2) cDNA(46) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034808 (Evidence)
Ensembl Gene ModelENSMUSG00000026579 (Evidence)
Entrez Gene14067 (Evidence)
UniGene12900
DFCITC1582458, TC1609309, TC1700496
DoTSDT.496636
NIA Mouse Gene IndexU001016
Consensus CDS ProjectCCDS35754.1
International Mouse Knockout Project StatusF5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034808 VEGA Gene Model | MGI Sequence Detail 68440 C57BL/6J ±  kb
transcript OTTMUST00000088478 VEGA | MGI Sequence Detail 7430 Not Applicable 
polypeptide OTTMUSP00000048218 VEGA | MGI Sequence Detail 2183 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(722 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR009271 Coagulation factor V, LSPD
InterPro IPR008972 Cupredoxin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR002355 Multicopper oxidase, copper-binding site
InterPro IPR011707 Multicopper oxidase, type 3
Protein Ontology PR:000007300 coagulation factor V
References (Earliest) J:9416 Dahlback B, et al., Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat. Somat Cell Mol Genet. 1988 Sep;14(5):509-14
(Latest) J:195883 An J, et al., Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model. Blood. 2013 Mar 14;121(11):2127-34
All references(57)
Other
accession IDs
MGD-MRK-1948, MGD-MRK-1954, MGI:2138166

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory