F5
Gene Detail

Symbol Name ID

F5 coagulation factor V MGI:88382

Synonyms

Cf5, Cf-5

Feature Type

protein coding gene

Genetic Map

Chromosome 1

71.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:164151838-164220277 bp, + strand From VEGA annotation of GRCm38   68440 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor V/coagulation factor VIII
Gene Tree: F5

Human homologs

Human Homolog		F5, coagulation factor V (proaccelerin, labile factor)
NCBI Gene ID		2153
neXtProt AC		NX_P12259
Human Synonyms		FVL, PCCF, RPRGL1, THPH2
Human Chr (Location)		1q23; chr1:169481192-169555769 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human F5

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Half of mice homozygous for a null allele die at E9-E10 with defects in yolk-sac vasculature and somite formation; the remaining half develop to term but die of massive hemorrhage within hours of birth. Mice homozygous for a knock-in (F5 Leiden) allele develop strain-specific perinatal thrombosis.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	blood circulation, blood coagulation, ...
Component	extracellular region, extracellular space, ...
Function	copper ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (32)    Tissues (13)    Images (24)
Theiler Stages: 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	23
RT-PCR	9

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(2) cDNA(46) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034808 (Evidence)
Ensembl Gene Model	ENSMUSG00000026579 (Evidence)
Entrez Gene	14067 (Evidence)
UniGene	12900
DFCI	TC1582458, TC1609309, TC1700496
DoTS	DT.496636
NIA Mouse Gene Index	U001016
Consensus CDS Project	CCDS35754.1
International Mouse Knockout Project Status	F5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034808	VEGA Gene Model | MGI Sequence Detail	68440	C57BL/6J
transcript	OTTMUST00000088478	VEGA | MGI Sequence Detail	7430	Not Applicable
polypeptide	OTTMUSP00000048218	VEGA | MGI Sequence Detail	2183	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(425 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000421	Coagulation factor 5/8 C-terminal type domain
InterPro	IPR009271	Coagulation factor V, LSPD
InterPro	IPR008972	Cupredoxin
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR002355	Multicopper oxidase, copper-binding site
InterPro	IPR011707	Multicopper oxidase, type 3
Protein Ontology	PR:000007300	coagulation factor V

References

(Earliest) J:9416 Dahlback B, et al., Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat. Somat Cell Mol Genet. 1988 Sep;14(5):509-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(54)

Other accession IDs

MGD-MRK-1948, MGD-MRK-1954, MGI:2138166