About   Help   FAQ
F3 Gene Detail
Summary
  • Symbol
    F3
  • Name
    coagulation factor III
  • Synonyms
    CD142, Cf3, Cf-3, TF, tissue factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88381
    NCBI Gene: 14066
  • Gene Overview
    MyGene.info: F3
Location & Maps
more
  • Sequence Map
    Chr3:121723537-121735048 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11512 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    F3, coagulation factor III, tissue factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F3, coagulation factor III, tissue factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD142, TF, TFA
  • Links
    NCBI Gene ID: 2152
    neXtProt AC: NX_P13726

  • Chr Location
    1p22-p21; chr1:94529176-94541857 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 8 alleles in 11 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    10
  • Transgenic
    2
  • Genomic Mutations
    2 involving F3
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired blood vessel development, retarded growth, and, in most cases, midgestational lethality. On a mixed background, some mutants survive to birth and appear to be normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052233 VEGA Gene Model | MGI Sequence Detail 11512 C57BL/6J ±  kb
transcript OTTMUST00000131223 VEGA | MGI Sequence Detail 1872 Not Applicable  
polypeptide OTTMUSP00000070221 VEGA | MGI Sequence Detail 294 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    229 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    Genomic 1
    cDNA 50
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1947, MGD-MRK-1953, MGI:2139567
References
more
  • Summaries
    All 108
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 65
  • Earliest
    J:9927 Hartzell S, et al., A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol. 1989 Jun;9(6):2567-73
  • Latest
    J:222109 Liang HP, et al., EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30;125(18):2845-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory