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F3
Gene Detail
Symbol

Name
ID
F3
coagulation factor III
MGI:88381
Synonyms
CD142, Cf3, Cf-3, TF, tissue factor
Feature Type
protein coding gene
Genetic Map
Chromosome 3
52.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:121723537-121735052 bp, + strand
From NCBI annotation of GRCm38

  11516 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:1511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: tissue factor/coagulation factor III
Gene Tree: F3

Human
homologs
Human Homolog F3, coagulation factor III (thromboplastin, tissue factor)
NCBI Gene ID 2152
neXtProt AC  NX_P13726
Human Synonyms  CD142, TF, TFA
Human Chr (Location)  1p22-p21; chr1:94529176-94541857 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired blood vessel development, retarded growth, and, in most cases, midgestational lethality. On a mixed background, some mutants survive to birth and appear to be normal.
 
Interactions
F3 interacts with 158 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Expression
Literature Summary: (10 records)
Data Summary: Results (203)    Tissues (39)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
RT-PCR 15
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(49) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028128 (Evidence)
Entrez Gene14066 (Evidence)
UniGene273188
DFCITC1580377, TC1603907
DoTSDT.529175, DT.94235722
NIA Mouse Gene IndexU003796
Consensus CDS ProjectCCDS17805.1
International Mouse Knockout Project StatusF3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14066 NCBI Gene Model | MGI Sequence Detail 11516 C57BL/6J ±  kb
transcript NM_010171 RefSeq | MGI Sequence Detail 1876 Not Specified 
polypeptide P20352 UniProt | EBI | MGI Sequence Detail 294 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
InterPro IPR001187 Tissue factor
InterPro IPR016354 Tissue factor/coagulation factor III
Protein Ontology PR:000001940 tissue factor
Graphical View of Protein Domain Structure
References
(Earliest) J:9927 Hartzell S, et al., A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol. 1989 Jun;9(6):2567-73
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(106)
Other
accession IDs
MGD-MRK-1947, MGD-MRK-1953, MGI:2139567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory