Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable cytokine receptor activity; phospholipid binding activity; and protease binding activity. Predicted to contribute to serine-type endopeptidase activity. Predicted to be involved in several processes, including activation of plasma proteins involved in acute inflammatory response; positive regulation of signal transduction; and positive regulation of smooth muscle cell migration. Predicted to act upstream of or within positive regulation of interleukin-8 production. Predicted to be located in cell surface; collagen-containing extracellular matrix; and extracellular space. Predicted to be part of serine-type peptidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor).