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Cebpb Gene Detail
Summary
  • Symbol
    Cebpb
  • Name
    CCAAT/enhancer binding protein beta
  • Synonyms
    C/EBPbeta, C/EBP BETA, CRP2, IL-6DBP, LAP, LIP, Nfil6, NF-IL6, NF-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:88373
    NCBI Gene: 12608
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167530835-167532338 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 87.58 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88373
protein coding gene Chr2:167530835-167532352 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026918
protein coding gene Chr2:173459087-173460590 (+)
A/J MGP_AJ_G0026885
protein coding gene Chr2:166308125-166309628 (+)
AKR/J MGP_AKRJ_G0026856
protein coding gene Chr2:171266239-171267748 (+)
BALB/cJ MGP_BALBcJ_G0026894
protein coding gene Chr2:166659550-166661053 (+)
C3H/HeJ MGP_C3HHeJ_G0026636
protein coding gene Chr2:171635577-171637080 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027341
protein coding gene Chr2:178519948-178521451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024712
protein coding gene Chr2:159612275-159613765 (+)
CAST/EiJ MGP_CASTEiJ_G0026094
protein coding gene Chr2:172103124-172104628 (+)
CBA/J MGP_CBAJ_G0026613
protein coding gene Chr2:185075100-185076603 (+)
DBA/2J MGP_DBA2J_G0026751
protein coding gene Chr2:165411249-165412752 (+)
FVB/NJ MGP_FVBNJ_G0026717
protein coding gene Chr2:163951425-163952928 (+)
LP/J MGP_LPJ_G0026852
protein coding gene Chr2:173471532-173473035 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026736
protein coding gene Chr2:188426834-188428337 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027398
protein coding gene Chr2:171197002-171198505 (+)
PWK/PhJ MGP_PWKPhJ_G0025831
protein coding gene Chr2:165087601-165089113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025632
protein coding gene Chr2:170143496-170145005 (+)
WSB/EiJ MGP_WSBEiJ_G0026167
protein coding gene Chr2:172102966-172104471 (+)



Homology
more
  • Human Ortholog
    CEBPB, CCAAT enhancer binding protein beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEBPB, CCAAT enhancer binding protein beta
  • Synonyms
    C/EBP-beta, IL6DBP, NF-IL6, TCF5
  • Links
    NCBI Gene ID: 1051
    neXtProt AC: NX_P17676
    UniProt: P17676

  • Chr Location
    20q13.13; chr20:50190583-50192690 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Cebpb mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    141 phenotypes from 12 alleles in 17 genetic backgrounds
    62 phenotypes from multigenic genotypes
    4 images
    147 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit high neonatal hypoglycemia and mortality, reduced epididymal fat pad weight, susceptibility to Listeria monocytogenes, female sterility, impaired mammary development, and resistance to skin carcinogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056501 Ensembl Gene Model | MGI Sequence Detail 1504 C57BL/6J ±  kb
    transcript ENSMUST00000070642 Ensembl | MGI Sequence Detail 1504 Not Applicable  
    polypeptide ENSMUSP00000069850 Ensembl | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 4
      cDNA 55
      Primer pair 9
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12827, MGD-MRK-1917, MGI:97310
    References
    more
    • Summaries
      All 402
      Developmental Gene Expression 60
      Diseases 2
      Gene Ontology 64
      Phenotypes 147
    • Earliest
      J:27206 Chang CJ, et al., Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol Cell Biol. 1990 Dec;10(12):6642-53
    • Latest
      J:343307 Vanickova K, et al., Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis. EMBO J. 2023 Dec 1;42(23):e113527

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory