Cebpb
Gene Detail

Symbol Name ID

Cebpb CCAAT/enhancer binding protein (C/EBP), beta MGI:88373

Synonyms

C/EBPbeta, C/EBP BETA, CRP2, IL-6DBP, LAP, LIP, Nfil6, NF-IL6, NF-M

Feature Type

protein coding gene

Genetic Map

Chromosome 2

87.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr2:167688915-167690418 bp, + strand From VEGA annotation of GRCm38   1504 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpb

Human homologs

Human Homolog		CEBPB, CCAAT/enhancer binding protein (C/EBP), beta
NCBI Gene ID		1051
neXtProt AC		NX_P17676
Human Synonyms		C/EBP-beta, CRP2, IL6DBP, LAP, NF-IL6, TCF5
Human Chr (Location)		20q13.1; chr20:48807120-48809227 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Homozygotes for targeted null mutations exhibit high neonatal hypoglycemia and mortality, reduced epididymal fat pad weight, susceptibility to Listeria monocytogenes, female sterility, impaired mammary development, and resistance to skin carcinogenesis.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	brown fat cell differentiation, cell differentiation, ...
Component	cytoplasm, nuclear chromatin, ...
Function	DNA binding, glucocorticoid receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (192)    Tissues (132)    Images (16)
Theiler Stages: 11, 15, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	133
Northern blot	34
Western blot	12
RT-PCR	11

cDNA source data(50)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(62) Genomic(4) cDNA(53) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016307 (Evidence)
Ensembl Gene Model	ENSMUSG00000056501 (Evidence)
Entrez Gene	12608 (Evidence)
UniGene	439656
DFCI	TC1581829
DoTS	DT.486837, DT.97359798
NIA Mouse Gene Index	U002854
PDB	1CI6
Consensus CDS Project	CCDS17105.1
International Mouse Knockout Project Status	Cebpb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016307	VEGA Gene Model | MGI Sequence Detail	1504	C57BL/6J
transcript	OTTMUST00000039186	VEGA | MGI Sequence Detail	1504	Not Applicable
polypeptide	OTTMUSP00000017503	VEGA | MGI Sequence Detail	296	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR016468	CCAAT/enhancer-binding
Protein Ontology	PR:000005308	CCAAT/enhancer-binding protein beta

References

(Earliest) J:27206 Chang CJ, et al., Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol Cell Biol. 1990 Dec;10(12):6642-53
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(224)

Other accession IDs

MGD-MRK-12827, MGD-MRK-1917, MGI:97310