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Targeted Allele Detail
Symbol: Cebpbtm1Vpo
Name: CCAAT/enhancer binding protein (C/EBP), beta; targeted mutation 1, Valeria Poli
MGI ID: MGI:2149329
Synonyms: Cebpb-, C/EBPb-, C/EBPbeta-
Gene: Cebpb  Location: Chr2:167530835-167532338 bp, + strand  Genetic Position: Chr2, 87.58 cM
Alliance: Cebpbtm1Vpo page
Germline Transmission:  Earliest citation of germline transmission: J:25215
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn MC1-neocassette replaced the carboxy-terminal part of the gene, which encodes the leucine zipper and part of the basic domain. Generation of a null allele was confirmed by Western blots of hepatic tissue nuclear extracts. (J:25215)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cebpb Mutation:  20 strains or lines available
Mice homozygous for this targeted mutation exhibit a pathology that is almost identical to multicentric Castleman's disease in human patients, characterized by splenomegaly, peripheral lymphoadenopathy, enhanced hematopoiesis, and deregulated IL-6 production (J:25215).
Original:  J:25215 Screpanti I, et al., Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice [published erratum appears in EMBO J 1995 Jul 17;14(14):3596]. EMBO J. 1995 May 1;14(9):1932-41
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory