Cdc25c
Gene Detail

Symbol Name ID

Cdc25c cell division cycle 25C MGI:88350

Synonyms

Cdc25

Feature Type

protein coding gene

Genetic Map

Chromosome 18

18.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:34732997-34751533 bp, - strand From NCBI annotation of GRCm38   18537 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: protein-tyrosine-phosphatase Cdc25C
Gene Tree: Cdc25c

Human homologs

Human Homolog		CDC25C, cell division cycle 25C
NCBI Gene ID		995
neXtProt AC		NX_P30307
Human Synonyms		CDC25, PPP1R60
Human Chr (Location)		5q31; chr5:137620959-137667516 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(1) Gene trapped(7)
 

Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cell cycle, cell division, ...
Component	cytoplasm, intracellular, ...
Function	hydrolase activity, phosphoprotein phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (45)    Tissues (23)    Images (10)
Theiler Stages: 17, 20, 22, 24, 25, 28

Assay Type	Results
RNA in situ	10
Northern blot	25
Western blot	10

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(42)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000044201 (Evidence)
Entrez Gene	12532 (Evidence)
UniGene	286602
DFCI	TC1579191, TC1596235, TC1672590
DoTS	DT.525527, DT.55114045, DT.99850667
NIA Mouse Gene Index	U038313
EC	3.1.3.48
Consensus CDS Project	CCDS37759.1
International Mouse Knockout Project Status	Cdc25c

Sequences

Length	Strain/Species
genomic	12532	NCBI Gene Model | MGI Sequence Detail	18537	C57BL/6J
transcript	NM_009860	RefSeq | MGI Sequence Detail	1941	C57BL/6
polypeptide	P48967	UniProt | EBI | MGI Sequence Detail	447	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000751	M-phase inducer phosphatase
InterPro	IPR001763	Rhodanese-like domain
Protein Ontology	PR:000005193	M-phase inducer phosphatase 3

Graphical View of Protein Domain Structure

References

(Earliest) J:1241 Sartor H, et al., Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. Genomics. 1992 Jul;13(3):911-2
(Latest) J:190430 Sun JH, et al., Differential expression of Axin1, Cdc25c and Cdkn2d mRNA in 2-cell stage mouse blastomeres. Zygote. 2012 Aug;20(3):305-10
All references(47)

Other accession IDs

MGD-MRK-1876, MGD-MRK-1877