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Cdc25c
Gene Detail
Symbol

Name
ID
Cdc25c
cell division cycle 25C
MGI:88350
Synonyms
Cdc25
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:34732997-34751533 bp, - strand
From Ensembl annotation of GRCm38

  18537 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CDC25C
Protein SuperFamily: protein-tyrosine-phosphatase Cdc25C
Gene Tree: Cdc25c

Human
homologs
CDC25C, cell division cycle 25C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 995
neXtProt AC: NX_P30307

Human Synonyms: CDC25, PPP1R60

Human Chr (Location): 5q31; chr5:138285265-138338355 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(7) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses.
 
Interactions
Cdc25c interacts with 39 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, intracellular, ...
Function hydrolase activity, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (45)    Tissues (23)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
Northern blot 25
Western blot 10
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdc25c    NEW 
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000044201 (Evidence)
Entrez Gene 12532 (Evidence)
UniGene 286602
DFCI TC1579191, TC1596235, TC1672590
DoTS DT.525527, DT.55114045, DT.99850667
NIA Mouse Gene Index U038313
EC 3.1.3.48
Consensus CDS Project CCDS37759.1
International Mouse Phenotyping Consortium Status Cdc25c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044201 Ensembl Gene Model | MGI Sequence Detail 18537 C57BL/6J ±  kb
transcript ENSMUST00000060710 Ensembl | MGI Sequence Detail 1941 Not Applicable 
polypeptide ENSMUSP00000055427 Ensembl | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000751 M-phase inducer phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000005193 M-phase inducer phosphatase 3
References
(Earliest) J:1241 Sartor H, et al., Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. Genomics. 1992 Jul;13(3):911-2
(Latest) J:201041 Park DS, et al., Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system. Biol Open. 2013;2:968-978
All references(48)
Other
accession IDs
MGD-MRK-1876, MGD-MRK-1877

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory