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Cdc25c
Gene Detail
 Symbol
Name
ID
Cdc25c
cell division cycle 25C
MGI:88350
Synonyms Cdc25
Feature Type protein coding gene
Genetic Map
Chromosome 18
18.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:34732997-34751533 bp, - strand
From NCBI annotation of GRCm38

  18537 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: protein-tyrosine-phosphatase Cdc25C
Gene Tree: Cdc25c

Human
homologs
Human Homolog CDC25C, cell division cycle 25C
NCBI Gene ID 995
neXtProt AC  NX_P30307
Human Synonyms  CDC25, PPP1R60
Human Chr (Location)  5q31; chr5:138285265-138338355 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(7) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, intracellular, ...
Function hydrolase activity, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (45)    Tissues (23)    Images (10)
Theiler Stages: 17, 20, 22, 24, 25, 28
Assay TypeResults
RNA in situ 10
Northern blot 25
Western blot 10
cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000044201 (Evidence)
Entrez Gene12532 (Evidence)
UniGene286602
DFCITC1579191, TC1596235, TC1672590
DoTSDT.525527, DT.55114045, DT.99850667
NIA Mouse Gene IndexU038313
EC3.1.3.48
Consensus CDS ProjectCCDS37759.1
International Mouse Knockout Project StatusCdc25c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12532 NCBI Gene Model | MGI Sequence Detail 18537 C57BL/6J ±  kb
transcript NM_009860 RefSeq | MGI Sequence Detail 1941 C57BL/6 
polypeptide P48967 UniProt | EBI | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000751 M-phase inducer phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000005193 M-phase inducer phosphatase 3
Graphical View of Protein Domain Structure
References (Earliest) J:1241 Sartor H, et al., Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. Genomics. 1992 Jul;13(3):911-2
(Latest) J:201041 Park DS, et al., Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system. Biol Open. 2013;2:968-978
All references(49)
Other
accession IDs
MGD-MRK-1876, MGD-MRK-1877

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory