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Cd8a Gene Detail
Summary
  • Symbol
    Cd8a
  • Name
    CD8 antigen, alpha chain
  • Synonyms
    Ly-2, Ly-35, Ly-B, Lyt-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88346
    NCBI Gene: 12525
  • Gene Overview
    MyGene.info: CD8A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71373427-71379171 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.14 cM, cytoband C
  • Mapping Data
    67 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88346
protein coding gene Chr6:71373427-71379173 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030857
protein coding gene Chr6:71849732-71854529 (+)
A/J MGP_AJ_G0030827
protein coding gene Chr6:69084573-69088632 (+)
AKR/J MGP_AKRJ_G0030756
protein coding gene Chr6:71066698-71070779 (+)
BALB/cJ MGP_BALBcJ_G0030838
protein coding gene Chr6:69116950-69121178 (+)
C3H/HeJ MGP_C3HHeJ_G0030874
protein coding gene Chr6:113176288-113180358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031296
protein coding gene Chr6:73740391-73745169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028485
protein coding gene Chr6:68266010-68271500 (+)
CAST/EiJ MGP_CASTEiJ_G0029946
protein coding gene Chr6:70930223-70936553 (+)
CBA/J MGP_CBAJ_G0030525
protein coding gene Chr6:76666456-76676852 (+)
DBA/2J MGP_DBA2J_G0030677
protein coding gene Chr6:68460370-68464455 (+)
FVB/NJ MGP_FVBNJ_G0030630
protein coding gene Chr6:67826447-67830601 (+)
LP/J MGP_LPJ_G0030756
protein coding gene Chr6:71775585-71779972 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030665
protein coding gene Chr6:80157305-80161377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031322
protein coding gene Chr6:70914042-70918096 (+)
PWK/PhJ MGP_PWKPhJ_G0029662
protein coding gene Chr6:67328964-67335237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029490
protein coding gene Chr6:69619207-69623244 (+)
WSB/EiJ MGP_WSBEiJ_G0030028
protein coding gene Chr6:71252705-71257892 (+)



Homology
more
  • Human Ortholog
    CD8A, CD8a molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD8A, CD8a molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD8, Leu2, p32
  • Links
    NCBI Gene ID: 925
    neXtProt AC: NX_P01732
    UniProt: P01732

  • Chr Location
    2p11.2; chr2:86784605-86808396 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 14 alleles in 16 genetic backgrounds
    34 phenotypes from multigenic genotypes
    280 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12525 NCBI Gene Model | MGI Sequence Detail 5745 C57BL/6J ±  kb
transcript NM_001081110 RefSeq | MGI Sequence Detail 3130 Not Specified  
polypeptide P01731 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 59
    Genomic 18
    cDNA 38
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11958, MGD-MRK-11976, MGD-MRK-12074, MGD-MRK-1872, MGI:2141733
References
more
  • Summaries
    All 520
    Developmental Gene Expression 12
    Gene Ontology 45
    Phenotypes 280
  • Earliest
    J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
  • Latest
    J:262543 Lu Y, et al., Th9 Cells Represent a Unique Subset of CD4(+) T Cells Endowed with the Ability to Eradicate Advanced Tumors. Cancer Cell. 2018 Jun 11;33(6):1048-1060.e7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory