Cd8a
Gene Detail

Symbol Name ID

Cd8a CD8 antigen, alpha chain MGI:88346

STS

D6Mit16

Synonyms

Ly-2, Ly-35, Ly-B, Lyt-2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

32.14 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(67)

Sequence Map

Chr6:71373427-71379171 bp, + strand From NCBI annotation of GRCm38   5745 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1339  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 16 chicken

Protein SuperFamily: T-cell surface glycoprotein CD8 alpha chain
Gene Tree: Cd8a

Human homologs

Human Homolog		CD8A, CD8a molecule
NCBI Gene ID		925
neXtProt AC		NX_P01732
Human Synonyms		CD8, Leu2, MAL, p32
Human Chr (Location)		2p12; chr2:87011728-87035519 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD8A

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell surface receptor signaling pathway, cytotoxic T cell differentiation, ...
Component	cell surface, external side of plasma membrane, ...
Function	protein homodimerization activity, protein kinase binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) Genomic(18) cDNA(37) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000053977 (Evidence)
Entrez Gene	12525 (Evidence)
UniGene	1858
DFCI	TC1580454, TC1587101
DoTS	DT.101721974, DT.101724847, DT.528549
NIA Mouse Gene Index	U007018
PDB	1BQH, 1NEZ, 2ARJ, 2ATP, 3B9K, 3DMM
Consensus CDS Project	CCDS39507.1, CCDS51806.1
International Mouse Knockout Project Status	Cd8a

Sequences

Length	Strain/Species
genomic	12525	NCBI Gene Model | MGI Sequence Detail	5745	C57BL/6J
transcript	NM_001081110	RefSeq | MGI Sequence Detail	3130	Not Specified
polypeptide	P01731	UniProt | EBI | MGI Sequence Detail	247	Not Applicable

All sequences(40) RefSeq(4) UniProt(8)

Polymorphisms

PCR(1) : SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015468	CD8 alpha subunit
InterPro	IPR013151	Immunoglobulin
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
Protein Ontology	PR:000001084	T-cell surface glycoprotein CD8 alpha chain

Graphical View of Protein Domain Structure

References

(Earliest) J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
(Latest) J:193702 Hutchins NA, et al., Kupffer Cells Protect Liver Sinusoidal Endothelial Cells from Fas-Dependent Apoptosis in Sepsis by Down-Regulating gp130. Am J Pathol. 2013 Mar;182(3):742-54
All references(417)

Other accession IDs

MGD-MRK-11958, MGD-MRK-11976, MGD-MRK-12074, MGD-MRK-1872, MGI:2141733