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Cd8a
Gene Detail
 Symbol
Name
ID
Cd8a
CD8 antigen, alpha chain
MGI:88346
STS D6Mit16
Synonyms Ly-2, Ly-35, Ly-B, Lyt-2
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.14 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(67)
Sequence Map
Chr6:71373427-71379171 bp, + strand
From NCBI annotation of GRCm38

  5745 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: T-cell surface glycoprotein CD8 alpha chain
Gene Tree: Cd8a

Human
homologs
Human Homolog CD8A, CD8a molecule
NCBI Gene ID 925
neXtProt AC  NX_P01732
Human Synonyms  CD8, Leu2, MAL, p32
Human Chr (Location)  2p12; chr2:86784605-86808396 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD8A
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
 
Interactions
Cd8a interacts with 276 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell surface receptor signaling pathway, cytotoxic T cell differentiation, ...
Component cell surface, external side of plasma membrane, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(18) cDNA(37) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000053977 (Evidence)
Entrez Gene12525 (Evidence)
UniGene1858
DFCITC1580454, TC1587101
DoTSDT.101721974, DT.101724847, DT.528549
NIA Mouse Gene IndexU007018
PDB1BQH, 1NEZ, 2ARJ, 2ATP, 3B9K, 3DMM
Consensus CDS ProjectCCDS39507.1, CCDS51806.1
International Mouse Knockout Project StatusCd8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12525 NCBI Gene Model | MGI Sequence Detail 5745 C57BL/6J ±  kb
transcript NM_001081110 RefSeq | MGI Sequence Detail 3130 Not Specified 
polypeptide P01731 UniProt | EBI | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(8)
Polymorphisms PCR(1) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015468 CD8 alpha subunit
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001084 T-cell surface glycoprotein CD8 alpha chain
Graphical View of Protein Domain Structure
References (Earliest) J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
(Latest) J:210252 Ma F, et al., The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol. 2014 Apr 1;192(7):3365-73
All references(437)
Other
accession IDs
MGD-MRK-11958, MGD-MRK-11976, MGD-MRK-12074, MGD-MRK-1872, MGI:2141733

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory